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Medications for Opioid Use Disorder

Other names: Opiate Dependence; Opioid Dependence; Opioid Use Disorder

Opiate Dependence means that a person needs an opiate drug to function normally. Abruptly stopping the drug leads to withdrawal symptoms. Opiate drugs include heroin, fentanyl, hydrocodone, morphine, codeine, oxycodone and methadone.

Drugs used to treat Opioid Use Disorder

The following list of medications are in some way related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Suboxone 8.6 707 reviews for Suboxone to treat Opioid Use Disorder
Rx C 3 X
Generic name:
buprenorphine / naloxone systemic
Drug class:
narcotic analgesic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
buprenorphine / naloxone 7.8 1093 reviews for buprenorphine / naloxone to treat Opioid Use Disorder
Rx C 3 X
Generic name:
buprenorphine / naloxone systemic
Brand names:
Suboxone, Zubsolv
Drug class:
narcotic analgesic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
buprenorphine 8.6 293 reviews for buprenorphine to treat Opioid Use Disorder
Rx C 3 X
Generic name:
buprenorphine systemic
Brand names:
Sublocade, Brixadi
Drug class:
Opioids (narcotic analgesics)
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Vivitrol 7.5 127 reviews for Vivitrol to treat Opioid Use Disorder
Rx C N X
Generic name:
naltrexone systemic
Drug class:
drugs used in alcohol dependence
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
naltrexone 7.4 161 reviews for naltrexone to treat Opioid Use Disorder
Rx C N X
Generic name:
naltrexone systemic
Brand name:
Vivitrol
Drug class:
antidotes, drugs used in alcohol dependence
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Zubsolv 7.4 121 reviews for Zubsolv to treat Opioid Use Disorder
Rx C 3 X
Generic name:
buprenorphine / naloxone systemic
Drug class:
narcotic analgesic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Sublocade 8.5 136 reviews for Sublocade to treat Opioid Use Disorder
Rx C 3 X
Generic name:
buprenorphine systemic
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Brixadi 7.0 1 review for Brixadi to treat Opioid Use Disorder
Rx C 3 X
Generic name:
buprenorphine systemic
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information

Frequently asked questions

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Topics under Opioid Use Disorder

Learn more about Opioid Use Disorder

Care guides

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.