How does Lucemyra work in the treatment of opioid withdrawal?
Medically reviewed by Drugs.com. Last updated on May 30, 2025.
Lucemyra (lofexidine hydrochloride) is an oral, selective alpha 2-adrenergic receptor agonist and works by reducing the release of norepinephrine. The actions of norepinephrine, a central nervous system chemical messenger (neurotransmitter), are believed to play a role in many of the symptoms of opioid withdrawal.
Opioid withdrawal symptoms may include:
- anxiety
- agitation
- sleep problems
- muscle aches
- runny nose
- sweating
- nausea and vomiting
- diarrhea
- drug craving
Read next
How does Lucemyra make you feel?
Lucemyra may make you feel the symptoms of acute opioid withdrawal less intensely, but it will not block them altogether. Continue reading
Is Lucemyra (lofexidine) a controlled drug?
Lucemyra (lofexidine) is not a controlled substance, it is a central alpha-2 adrenergic agonist. Here's why some people might think its a controlled substance... Continue reading
How long does lofexidine typically take to work?
Lofexidine starts to work shortly after taking a single dose by mouth. The drug reaches maximum concentration in your blood in 3 to 5 hours. Continue reading
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Drug information
- Lucemyra Information for Consumers
- Lucemyra prescribing info & package insert (for Health Professionals)
- Side Effects of Lucemyra (detailed)
- Lucemyra user reviews (47)
Related support groups
- Lucemyra (4 questions, 7 members)
- Opiate Withdrawal (60 questions, 2,350 members)