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How does Lucemyra work in the treatment of opioid withdrawal?

Medically reviewed by Last updated on May 30, 2023.

Official answer


Lucemyra (lofexidine hydrochloride) is an oral, selective alpha 2-adrenergic receptor agonist and works by reducing the release of norepinephrine. The actions of norepinephrine, a central nervous system chemical messenger (neurotransmitter), are believed to play a role in many of the symptoms of opioid withdrawal.

Opioid withdrawal symptoms may include:

  • anxiety
  • agitation
  • sleep problems
  • muscle aches
  • runny nose
  • sweating
  • nausea and vomiting
  • diarrhea
  • drug craving

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