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Desvenlafaxine Dosage

Medically reviewed by Drugs.com. Last updated on Aug 16, 2023.

Applies to the following strengths: (as succinate) 25 mg; (as succinate) 50 mg; (as succinate) 100 mg; (as base) 50 mg; (as base) 100 mg

Usual Adult Dose for Depression

50 mg orally once a day, with or without food


Comments:

Use: Treatment of major depressive disorder (MDD)

Renal Dose Adjustments

Mild renal dysfunction (CrCl greater than 50 mL/min): No adjustment recommended.
Moderate renal dysfunction (CrCl 30 to 50 mL/min): 50 mg orally once a day
Severe renal dysfunction (CrCl less than 30 mL/min) OR end-stage renal disease (CrCl less than 15 mL/min): 25 mg orally once a day OR 50 mg orally every other day

Liver Dose Adjustments

Mild liver dysfunction (Child-Pugh Class A): No adjustment recommended.

Moderate to severe liver dysfunction (Child-Pugh Class B to C): 50 mg per day

Dose Adjustments


Switching patients to/from MAOIs:

Patients who require urgent treatment with linezolid/IV methylene blue during treatment:

Precautions

US BOXED WARNINGS:
SUICIDAL THOUGHTS AND BEHAVIORS:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Supplemental doses should not be administered after dialysis.

Other Comments

Administration advice:


General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.