Medically reviewed by Sophia Entringer, PharmD. Last updated on Feb 2, 2020.
What is Pristiq?
Pristiq (desvenlafaxine) is an antidepressant belonging to a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). Desvenlafaxine affects chemicals in the brain that may be unbalanced in people with depression.
Pristiq is used to treat major depressive disorder.
Pristiq may also be used for purposes not listed in this medication guide.
Do not use Pristiq within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
Do not stop using this medicine without first talking to your doctor.
Before taking this medicine
Do not use Pristiq within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. A dangerous drug interaction could occur.
Some medicines can interact with desvenlafaxine and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.
Tell your doctor if you have ever had:
depression, suicidal thoughts;
liver or kidney disease;
lung or breathing problems;
a bleeding or blood clotting disorder; or
low levels of sodium in your blood.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Ask your doctor about taking Pristiq if you are pregnant. Taking an SNRI antidepressant during late pregnancy could increase your risk of excessive bleeding just after you give birth, and may cause serious medical complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking Pristiq without your doctor's advice.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of desvenlafaxine on the baby.
It may not be safe to breastfeed a baby while you are using this medicine. Ask your doctor about any risks.
Pristiq is not FDA-approved for use by anyone younger than 18 years old.
How should I take Pristiq?
Take Pristiq exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take Pristiq with water at the same time each day, with or without food.
Swallow the tablet whole and do not crush, chew, or break it.
Your blood pressure will need to be checked regularly.
It may take several weeks before your symptoms improve. Do not stop using Pristiq without first talking to your doctor.
You may have unpleasant side effects if you stop taking this medicine suddenly. Follow your doctor's instructions about tapering your dose.
Some tablets are made with a shell that is not absorbed or melted in the body. Part of the tablet shell may appear in your stool. This is a normal side effect and will not make the medicine less effective.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Pristiq?
Avoid drinking alcohol.
Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with desvenlafaxine may cause you to bruise or bleed easily.
Desvenlafaxine may impair your thinking or reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.
Pristiq side effects
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
a seizure (convulsions);
blurred vision, eye pain or swelling, or seeing halos around lights;
cough, chest discomfort, trouble breathing; or
low levels of sodium in the body - headache, confusion, severe weakness, memory problems, feeling unsteady, hallucinations.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Common Pristiq side effects may include:
dizziness, drowsiness, anxiety;
nausea, decreased appetite, constipation;
sleep problems (insomnia); or
decreased sex drive, impotence, or difficulty having an orgasm.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Pristiq?
Taking Pristiq with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Many drugs (including some over-the-counter medicines and herbal products) can increase your risk of bleeding if you take them with Pristiq, especially:
This list is not complete and many other drugs may affect Pristiq. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Pristiq only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Drug class: serotonin-norepinephrine reuptake inhibitors
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