Generic Name: linezolid (oral/injection) (lin EZ oh lid)
Brand Name: Zyvox
Medically reviewed on April 16, 2018
What is linezolid?
Linezolid is an antibiotic that fights bacteria in the body. Linezolid is also an MAO (monoamine oxidase) inhibitor.
Linezolid may also be used for purposes not listed in this medication guide.
Some medicines can cause unwanted or dangerous effects when used with linezolid. Tell your doctor about all other medicines you use.
Before taking this medicine
You should not use linezolid if you are allergic to it.
Do not use linezolid if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.
Tell your doctor if you have ever had:
a thyroid disorder;
bone marrow suppression or a weak immune system;
kidney or liver disease;
pheochromocytoma (adrenal gland tumor);
if you use a catheter.
It is not known whether linezolid will harm an unborn baby. Tell your doctor if you are pregnant.
It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.
Linezolid liquid may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).
How is linezolid used?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Linezolid tablets or liquid can be taken with or without food.
Linezolid injection is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.
Prepare your injection only when you are ready to give it. Do not use if the medicine has particles in it. Call your pharmacist for new medicine.
Read and carefully follow any Instructions for Use provided with your medicine. Do not use linezolid if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.
Gently mix the oral suspension (liquid) by turning the bottle upside down 3 to 5 times. Do not shake. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
You will need frequent medical tests. Your vision and blood pressure may also need to be checked often.
Use linezolid for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Linezolid will not treat a viral infection such as the flu or a common cold.
Store all forms of linezolid at room temperature away from moisture, heat, and light. Do not freeze. Throw away any liquid not used within 21 days.
What happens if I miss a dose?
Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using linezolid?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.
Eating tyramine while you are using linezolid can raise your blood pressure to dangerous levels. Avoid foods that have a high level of tyramine, such as:
aged cheeses or meats;
pickled or fermented meats, smoked or air-dried meats;
tap beer (alcoholic and nonalcoholic);
red wine; or
any meat, cheese, or other protein-based food that has been improperly stored.
You should be very familiar with the list of foods you must avoid while you are using linezolid.
Linezolid side effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Call your doctor at once if you have:
vision problems, changes in color vision;
severe stomach pain, diarrhea that is watery or bloody;
sweating, feeling anxious or shaky (may be signs of low blood sugar);
low blood cell counts--fever, chills, tiredness, weakness, confusion, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Common side effects may include:
nausea, vomiting, diarrhea;
mild skin rash;
anemia (low red blood cells); or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect linezolid?
Some medicines can interact with linezolid and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.
Many drugs can interact with linezolid, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 10.01.
More about linezolid
- Linezolid Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 27 Reviews
- Drug class: oxazolidinone antibiotics
- Linezolid Tablets
- Linezolid Injection
- Linezolid Suspension
- Linezolid Intravenous (Advanced Reading)
- Linezolid Intravenous, Oral (Advanced Reading)
Other brands: Zyvox