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ofloxacin

Pronunciation

Generic Name: ofloxacin (oral) (oh FLOX a sin)
Brand Name: Floxin, Floxin I.V.

What is ofloxacin?

Ofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body.

Ofloxacin is used to treat bacterial infections of the skin, lungs, prostate, or urinary tract (bladder and kidneys). Ofloxacin is also used to treat pelvic inflammatory disease and Chlamydia and/or gonorrhea.

Fluoroquinolone antibiotics can cause serious or disabling side effects. Ofloxacin should be used only for infections that cannot be treated with a safer antibiotic.

Ofloxacin may also be used for purposes not listed in this medication guide.

What is the most important information I should know about ofloxacin?

Ofloxacin may cause swelling or tearing of a tendon, especially if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant.

What should I discuss with my healthcare provider before taking ofloxacin?

You should not use this medicine if you are allergic to ofloxacin or other fluoroquinolones (ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, and others).

To make sure ofloxacin is safe for you, tell your doctor if you have:

  • tendon problems, arthritis or other joint problems (especially in children);

  • a history of myasthenia gravis or other nerve-muscle disorder;

  • slow heartbeats or other heart rhythm disorder (especially if you take medication to treat it);

  • personal or family history of long QT syndrome;

  • liver or kidney disease;

  • a history of seizures;

  • diabetes (especially if you take oral diabetes medication);

  • low levels of potassium in your blood (hypokalemia); or

  • if you use a blood thinner (warfarin, Coumadin, Jantoven) and have "INR" or prothrombin time tests.

Ofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. This can happen during treatment or up to several months after you stop taking ofloxacin. Tendon problems may be more likely to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant.

Ofloxacin is not approved for use by anyone younger than 18 years old.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ofloxacin can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

How should I take ofloxacin?

Ofloxacin is usually taken every 12 hours. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take ofloxacin with water, and drink extra fluids to keep your kidneys working properly.

Ofloxacin may be taken with or without food, but take it at the same time each day.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Ofloxacin will not treat a viral infection such as the flu or a common cold.

Do not share this medicine with another person, even if they have the same symptoms you have.

This medicine can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking ofloxacin.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking ofloxacin?

Certain other medicines that should not be taken at the same time as ofloxacin. Avoid taking the following medicines within 2 hours before or after you take ofloxacin. These other medicines can make ofloxacin much less effective when taken at the same time:

  • antacids that contain calcium, magnesium, or aluminum (such as Amphojel, Di-Gel Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, Rulox, Tums, and others), or the ulcer medicine sucralfate (Carafate);

  • didanosine (Videx) powder or chewable tablets; or

  • vitamin or mineral supplements that contain aluminum, calcium, iron, magnesium, or zinc.

Ofloxacin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Avoid exposure to sunlight or tanning beds. Ofloxacin can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Call your doctor if you have severe burning, redness, itching, rash, or swelling after being in the sun.

Ofloxacin side effects

Get emergency medical help if you have signs of an allergic reaction: hives, or the first sign of a skin rash; fast heartbeat, difficult breathing; swelling of your face, lips, tongue, or throat.

Ofloxacin may cause swelling or tearing of (rupture) a tendon. Ofloxacin can also have serious effects on your nerves, and may cause permanent nerve damage.

Stop using ofloxacin and call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

  • muscle pain or weakness;

  • a seizure (convulsions);

  • sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, easy bruising or bleeding, pale skin;

  • signs of tendon rupture--sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions);

  • nerve symptoms--numbness, weakness, tingling, burning, pain, or being more sensitive to temperature, light touch, or the sense of your body position;

  • changes in mood or behavior--depression, confusion, hallucinations, paranoia, tremors, feeling restless or anxious, unusual thoughts or behavior, insomnia, nightmares;

  • liver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • increased pressure inside the skull--severe headaches, ringing in your ears, vision problems, pain behind your eyes; or

  • severe skin reaction--skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • nausea, constipation, diarrhea;

  • dizziness; or

  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Ofloxacin dosing information

Usual Adult Dose for Bronchitis:

400 mg orally every 12 hours for 10 days

Comments:
-Since fluoroquinolones (including this drug) have been associated with serious side effects and acute bacterial exacerbations of chronic bronchitis (ABECB) is self-limiting for some patients, this drug should be saved for treatment of ABECB in patients with no alternative treatment options.

Use: For the treatment of ABECB due to Haemophilus influenzae or Streptococcus pneumoniae

Usual Adult Dose for Pneumonia:

400 mg orally every 12 hours for 10 days

Uses: For the treatment of community-acquired pneumonia due to H influenzae or S pneumoniae; for the treatment of uncomplicated skin and skin structure infections due to methicillin-susceptible Staphylococcus aureus, S pyogenes, or Proteus mirabilis

Usual Adult Dose for Skin and Structure Infection:

400 mg orally every 12 hours for 10 days

Uses: For the treatment of community-acquired pneumonia due to H influenzae or S pneumoniae; for the treatment of uncomplicated skin and skin structure infections due to methicillin-susceptible Staphylococcus aureus, S pyogenes, or Proteus mirabilis

Usual Adult Dose for Gonococcal Infection -- Uncomplicated:

400 mg orally once

Uses: For the treatment of acute, uncomplicated urethral and cervical gonorrhea due to Neisseria gonorrhoeae

US CDC recommendations:
-Due to high rates of resistance, fluoroquinolones are not recommended for treatment of gonococcal infections in the US; dual therapy with ceftriaxone and azithromycin is the recommended regimen for treatment of gonorrhea in the US.
-Antimicrobial susceptibility patterns should be monitored.
-The patient's sexual partner(s) should also be evaluated/treated.
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Nongonococcal Urethritis:

300 mg orally every 12 hours for 7 days

Uses: For the treatment of nongonococcal cervicitis and urethritis due to Chlamydia trachomatis; for the treatment of mixed infection of the cervix and urethra due to C trachomatis and N gonorrhoeae

US CDC recommendations: 300 mg orally twice a day for 7 days

Comments:
-Recommended as an alternative regimen for nongonococcal urethritis and for chlamydial infection
-Due to high rates of resistance, fluoroquinolones are not recommended for treatment of gonococcal infections in the US; dual therapy with ceftriaxone and azithromycin is the recommended regimen for treatment of gonorrhea in the US.
-Antimicrobial susceptibility patterns should be monitored.
-The patient's sexual partner(s) should also be evaluated/treated.
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Chlamydia Infection:

300 mg orally every 12 hours for 7 days

Uses: For the treatment of nongonococcal cervicitis and urethritis due to Chlamydia trachomatis; for the treatment of mixed infection of the cervix and urethra due to C trachomatis and N gonorrhoeae

US CDC recommendations: 300 mg orally twice a day for 7 days

Comments:
-Recommended as an alternative regimen for nongonococcal urethritis and for chlamydial infection
-Due to high rates of resistance, fluoroquinolones are not recommended for treatment of gonococcal infections in the US; dual therapy with ceftriaxone and azithromycin is the recommended regimen for treatment of gonorrhea in the US.
-Antimicrobial susceptibility patterns should be monitored.
-The patient's sexual partner(s) should also be evaluated/treated.
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Cervicitis:

300 mg orally every 12 hours for 7 days

Uses: For the treatment of nongonococcal cervicitis and urethritis due to Chlamydia trachomatis; for the treatment of mixed infection of the cervix and urethra due to C trachomatis and N gonorrhoeae

US CDC recommendations: 300 mg orally twice a day for 7 days

Comments:
-Recommended as an alternative regimen for nongonococcal urethritis and for chlamydial infection
-Due to high rates of resistance, fluoroquinolones are not recommended for treatment of gonococcal infections in the US; dual therapy with ceftriaxone and azithromycin is the recommended regimen for treatment of gonorrhea in the US.
-Antimicrobial susceptibility patterns should be monitored.
-The patient's sexual partner(s) should also be evaluated/treated.
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Pelvic Inflammatory Disease:

400 mg orally every 12 hours for 10 to 14 days

Comments:
-If suspect infecting pathogens include anaerobic microorganisms, appropriate treatment for anaerobic pathogens should be used.

Use: For the treatment of acute pelvic inflammatory disease (including severe infection) due to C trachomatis and/or N gonorrhoeae

US CDC recommendations: 400 mg orally twice a day for 14 days

Comments:
-Recommended as an alternative agent for mild to moderately severe acute pelvic inflammatory disease (PID)
-Due to high rates of resistance, fluoroquinolones are not recommended for treatment of gonococcal infections in the US; as a result, regimens that include a quinolone are not recommended for the treatment of PID.
-If parenteral cephalosporin therapy is not possible, use of this drug (with oral metronidazole) can be considered if community prevalence and individual risk for gonorrhea are low.
-Prior to therapy, diagnostic tests for gonorrhea must be performed; if test results are positive for quinolone-resistant N gonorrhoeae and cephalosporin therapy is not possible, an infectious-disease specialist should be consulted.
-The patient's sexual partner(s) should also be evaluated/treated.
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Cystitis:

200 mg orally every 12 hours

Duration of therapy:
-For infections due to Escherichia coli or Klebsiella pneumoniae: 3 days
-For infections due to other organisms: 7 days

Comments:
-Since fluoroquinolones (including this drug) have been associated with serious side effects and uncomplicated cystitis is self-limiting for some patients, this drug should be saved for treatment of uncomplicated cystitis in patients with no alternative treatment options.

Use: For the treatment of uncomplicated cystitis due to Citrobacter diversus, Enterobacter aerogenes, E coli, K pneumoniae, P mirabilis, or Pseudomonas aeruginosa

Usual Adult Dose for Urinary Tract Infection:

200 mg orally every 12 hours for 10 days

Use: For the treatment of complicated urinary tract infections due to E coli, K pneumoniae, P mirabilis, C diversus, or P aeruginosa

Usual Adult Dose for Prostatitis:

300 mg orally every 12 hours for 6 weeks

Use: For the treatment of prostatitis due to E coli

Usual Adult Dose for Epididymitis -- Non-Specific:

US CDC recommendations: 300 mg orally twice a day for 10 days

Comments:
-A recommended regimen for acute epididymitis most likely due to enteric organisms
-With ceftriaxone, a recommended regimen for acute epididymitis most likely due to sexually-transmitted chlamydia and gonorrhea and enteric organisms (men practicing insertive anal sex)
-Due to high rates of resistance, fluoroquinolones are not recommended for treatment of gonococcal infections in the US; use of this drug should be considered if infection is most likely due to enteric organisms and tests have ruled out gonorrhea.
-All patients should be tested for other sexually-transmitted infections (including HIV).
-The patient's sexual partner(s) should also be evaluated/treated.
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Epididymitis -- Sexually Transmitted:

US CDC recommendations: 300 mg orally twice a day for 10 days

Comments:
-A recommended regimen for acute epididymitis most likely due to enteric organisms
-With ceftriaxone, a recommended regimen for acute epididymitis most likely due to sexually-transmitted chlamydia and gonorrhea and enteric organisms (men practicing insertive anal sex)
-Due to high rates of resistance, fluoroquinolones are not recommended for treatment of gonococcal infections in the US; use of this drug should be considered if infection is most likely due to enteric organisms and tests have ruled out gonorrhea.
-All patients should be tested for other sexually-transmitted infections (including HIV).
-The patient's sexual partner(s) should also be evaluated/treated.
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Pyelonephritis:

Some experts recommend: 200 to 400 mg orally every 12 hours for 7 to 14 days

Comments:
-Recommended as empiric therapy in uncomplicated acute pyelonephritis
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Shigellosis:

Infectious Diseases Society of America (IDSA) recommendations: 300 mg orally twice a day

Duration of Therapy:
-Immunocompetent patients: 3 days
-Immunocompromised patients: 7 to 10 days (Shigella species); 3 days (other listed pathogens)

Comments:
-Recommended for Shigella species, E coli species (enterotoxigenic, enteropathogenic, enteroinvasive), Aeromonas, Plesiomonas
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Infectious Diarrhea:

Infectious Diseases Society of America (IDSA) recommendations: 300 mg orally twice a day

Duration of Therapy:
-Immunocompetent patients: 3 days
-Immunocompromised patients: 7 to 10 days (Shigella species); 3 days (other listed pathogens)

Comments:
-Recommended for Shigella species, E coli species (enterotoxigenic, enteropathogenic, enteroinvasive), Aeromonas, Plesiomonas
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Salmonella Enteric Fever:

IDSA recommendations: 300 mg orally twice a day

Duration of Therapy:
-Immunocompetent patients: 5 to 7 days
-Immunocompromised patients: 14 days (or longer if relapsing)

Comments:
-Recommended for non-typhi species of Salmonella if severe, patient is older than 50 years, or patient has prostheses, valvular heart disease, severe atherosclerosis, malignancy, or uremia
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Salmonella Gastroenteritis:

IDSA recommendations: 300 mg orally twice a day

Duration of Therapy:
-Immunocompetent patients: 5 to 7 days
-Immunocompromised patients: 14 days (or longer if relapsing)

Comments:
-Recommended for non-typhi species of Salmonella if severe, patient is older than 50 years, or patient has prostheses, valvular heart disease, severe atherosclerosis, malignancy, or uremia
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Traveler's Diarrhea:

IDSA recommendations: 200 mg orally twice a day
Duration of therapy: 24 hours to 3 days

Comments:
-Travelers should be provided with 3 days of treatment and should be advised to reevaluate themselves 24 hours after starting therapy; if not completely well at 24 hours, patients should be advised to continue therapy until well or until they have completed the 3-day regimen.
-Current guidelines should be consulted for additional information.

What other drugs will affect ofloxacin?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • theophylline;

  • a diuretic or "water pill";

  • heart rhythm medication--amiodarone, disopyramide, dofetilide, dronedarone, procainamide, quinidine, sotalol, and others;

  • medicine to treat depression or mental illness--amitriptylline, clomipramine, clozapine, desipramine, duloxetine, iloperidone, imipramine, nortriptyline, and others; or

  • NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may interact with ofloxacin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about ofloxacin.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 10.01.

Date modified: November 30, 2016
Last reviewed: July 05, 2016

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