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Written by C. Fookes, BPharm on April 12, 2018.

Other names: fluoroquinolones

What are Quinolones?

Quinolones are a type of antibiotic. Antibiotics kill or inhibit the growth of bacteria.

There are five different quinolone classes. In addition, another class of antibiotic, called fluoroquinolones, were derived from quinolones by modifying their structure with fluorine. Quinolones and fluoroquinolones have many things in common, but also a few differences such as what organisms they are effective against. Some people use the words quinolones and fluoroquinolones interchangeably.

Quinolones and fluoroquinolones detrimentally affect the function of two enzymes produced by bacteria, topoisomerase IV and DNA gyrase, so that they can no longer repair DNA or help in its manufacture.

What are quinolones and fluoroquinolones used for?

Quinolones and fluoroquinolones are considered broad-spectrum antibiotics. This means that they are effective against a wide range of bacteria.

However, because of their risk of serious side effects, the FDA has advised that they are not suitable for common conditions such as sinusitis, bronchitis, and uncomplicated urinary tract infections, and should only be considered when treatment with other, less toxic antibiotics, has failed.

Quinolones and fluoroquinolones may also be used to treat unusual infections such as anthrax or plague. Doctors may also decide to use them for other types of infection when other alternative treatment options have failed or cannot be used.

What are the differences between quinolones and fluoroquinolones?

Quinolones and fluoroquinolones differ in their activity against the two enzymes produced by bacteria, topoisomerase IV and DNA gyrase. Those that are more active against topoisomerase IV have more of an effect against gram-positive bacteria, those that are active against DNA gyrase, are more active against gram-negative bacteria. Newer fluoroquinolones tend to target these enzymes equally.

Quinolones and fluoroquinolones also differ in the way they are absorbed, metabolized and excreted in the body.

Table: List of common quinolones and fluoroquinolones

Generic name Brand name examples
cinoxacin Discontinued in the U.S.
ciprofloxacin Cipro, Proquin XR
delafloxacin Baxdela
gemifloxacin Factive
levofloxacin Levaquin
moxifloxacin Avelox
nalidixic acid Discontinued in the U.S.
norfloxacin Discontinued in the U.S.
ofloxacin Floxin
sparfloxacin Discontinued in the U.S.

Are quinolones and fluoroquinolones safe?

Quinolones and fluoroquinolones should be avoided in children under the age of 18 years unless they have a serious infection that cannot be treated with any other antibiotic. This is because they can damage the weight-bearing joints in children, and children are also more susceptible to other adverse effects of quinolones and fluoroquinolones, including tendinitis and tendon rupture.

The FDA has some concerns about quinolones and fluoroquinolones and considers them unsuitable for most common infections because they have been associated with some serious effects, including tendinitis (inflammation of a tendon) and tendon rupture. In addition, some people have reported peripheral neuropathy (nerve pain in the fingers and toes) and central nervous system effects such as agitation, attention problems, disorientation, memory impairment, nervousness, and delirium while taking quinolones or fluoroquinolones. They have also been associated with low blood sugar levels (hypoglycemia). All quinolones and fluoroquinolones are required by the FDA to carry safety warnings about these potentially serious side effects.

The risk of tendinitis and tendon rupture is increased in people over the age of 60, in those taking corticosteroids, or with a history of organ transplant. Previous tendon disorders or strenuous activity may also increase risk.

Occasionally, liver damage and allergic reactions have occurred in people taking quinolones or fluoroquinolones.

If any of these very severe side effects happen, the quinolone or fluoroquinolone should be discontinued immediately, and all other quinolones and fluoroquinolones avoided in the future.

What are the side effects of quinolones and fluoroquinolones?

The most commonly reported side effects include diarrhea, nausea, abnormal liver function tests, vomiting, and rash.

Quinolones and fluoroquinolones may also cause anxiety, insomnia, psychotic reactions, nerve pain or a loss of feeling in the extremities, electrocardiogram (ECG) abnormalities, increased sensitivity to light and other effects.

In people with myasthenia gravis, they may exacerbate muscle weakness and may trigger seizures or increase the risk of having a seizure.

In people with diabetes, quinolones and fluoroquinolones may affect blood glucose levels requiring extra monitoring.

Quinolones and fluoroquinolones increase the sensitivity of the skin to the sun and may cause photo-sensitivity reactions and severe sunburn on exposed areas of skin.

Quinolones and fluoroquinolones are not suitable for people with myasthenia gravis, certain heart rhythm disturbances, or children and adolescents under the age of 18 (unless the infection cannot be treated by another antibiotic).

List of Quinolones

View by  Brand | Generic
Drug Name Avg. Rating Reviews
Levaquin (Pro)
Generic name: levofloxacin
414 reviews
Cipro (Pro)
Generic name: ciprofloxacin
317 reviews
Avelox (Pro)
Generic name: moxifloxacin
160 reviews
Factive (Pro)
Generic name: gemifloxacin
9 reviews
Cipro XR
Generic name: ciprofloxacin
4 reviews
Generic name: nalidixic acid
3 reviews
Cipro I.V.
Generic name: ciprofloxacin
3 reviews
Generic name: norfloxacin
2 reviews
Generic name: ofloxacin
2 reviews
Proquin XR
Generic name: ciprofloxacin
1 review
Baxdela (Pro)
Generic name: delafloxacin
1 review
Avelox I.V. (Pro)
Generic name: moxifloxacin
1 review
Generic name: sparfloxacin
No reviews
Generic name: trovafloxacin
No reviews
Generic name: gatifloxacin
No reviews
Generic name: cinoxacin
No reviews
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.