Paroxetine Drug Interactions
A total of 937 drugs are known to interact with paroxetine.
- 224 major drug interactions
- 677 moderate drug interactions
- 36 minor drug interactions
Check for interactions
Most frequently checked interactions
View interaction reports for paroxetine and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Advair Diskus (fluticasone / salmeterol)
- alprazolam (Xanax, Xanax XR, Alprazolam Intensol, Niravam)
- amitriptyline (Elavil, Endep, Vanatrip)
- Aspirin Low Strength (aspirin)
- Calcium 600 D (calcium / vitamin d)
- Crestor (rosuvastatin)
- diazepam (Valium, Diastat, Diastat AcuDial, Diazepam Intensol, Valrelease, Dizac, Zetran, Diastat Pediatric)
- diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Sleep, Benadryl Children's Allergy, Diphen, Sominex, Unisom SleepGels, Nytol, Simply Sleep, Diphedryl, Dicopanol, Diphenhist, Diphenadryl, Quenalin, 40 Winks, Hydramine, Diphenydramine Quick Melt, Dormin, Hydramine Cough Syrup, Diphen Cough, Calm-Aid, Sleep Tabs, Diphenyl, Pharbedryl, Histaprin, Tranquil Nighttime Sleep Aid, Unisom SleepMelts, Sleepwell 2-nite, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Buckley's Bedtime, Hyrexin, Bydramine, Diphen AF, DPH, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Genahist, Alka-Seltzer Plus Allergy, Q-Dryl, Aller-G-Time, Sleep Tab II, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Altaryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Diphendryl, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Q-Dryl A/F, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Z-Sleep, PediaCare Children's Allergy, Truxadryl, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
- duloxetine (Cymbalta, Irenka)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- fluoxetine (Prozac, Prozac Weekly, Sarafem, Selfemra, Rapiflux)
- gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
- ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Motrin IB, Proprinal, Advil Children's, Caldolor, Children's Motrin, Childrens Ibuprofen Berry, Motrin Childrens, Rufen, Ibuprofen PMR, Ibu-8, Motrin Pediatric, Menadol, Nuprin, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Advil Migraine, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, NeoProfen, Ibu-Tab, Genpril, Haltran, IBU-200, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Actiprofen, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Motrin Junior Strength, Motrin Infant Drops, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
- Lipitor (atorvastatin)
- lorazepam (Ativan, Lorazepam Intensol)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Tartrate (metoprolol)
- Nexium (esomeprazole)
- Norco (acetaminophen / hydrocodone)
- phentermine (Adipex-P, Lomaira, Fastin, Suprenza, Ionamin, Teramine, Obenix, Atti-Plex P, Pro-Fast HS, Phentercot, Oby-Cap, Phentride, Obephen, Panshape M, Pro-Fast SR, T-Diet, Zantryl, Oby-Trim, Pro-Fast SA, Teramine ER)
- Plavix (clopidogrel)
- ProAir HFA (albuterol)
- propranolol (Inderal, Inderal LA, Hemangeol, InnoPran XL, Inderal XL)
- Seroquel (quetiapine)
- Synthroid (levothyroxine)
- tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Zydol, Tramahexal, Ryzolt, Tramal SR, ConZip, Larapam SR, GenRx Tramadol, Tramedo, Zamadol, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
- trazodone (Desyrel, Oleptro, Desyrel Dividose)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- warfarin (Coumadin, Jantoven)
- Wellbutrin (bupropion)
- Xanax (alprazolam)
- Zoloft (sertraline)
Paroxetine alcohol/food interactions
There is 1 alcohol/food interaction with paroxetine
Paroxetine disease interactions
There are 11 disease interactions with paroxetine which include:
- depression
- bone fractures
- renal dysfunction
- hyponatremia
- glaucoma
- liver disease
- mania
- platelet function
- seizure disorders
- SIADH
- weight loss
More about paroxetine
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Patient Tips
- Drug Images
- Compare Alternatives
- Support Group
- Pricing & Coupons
- En Español
- 1053 Reviews
- Drug class: selective serotonin reuptake inhibitors
- FDA Alerts (8)
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
