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Duloxetine for Hot Flashes User Reviews

Brand names: Cymbalta, Drizalma Sprinkle, Irenka

Rating: 6.4

Duloxetine has an average rating of 6.4 out of 10 from a total of 17 reviews for the off-label treatment of hot flashes. 53% of reviewers reported a positive experience, while 29% reported a negative experience.

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6%
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41%
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6%
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12%
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6%
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6%
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6%
1
18%

Reviews for Duloxetine

  • Anonymous
  • Taken for 2 to 5 years
  • February 7, 2017

"I feel so hot with the Cymbalta. Different than hot flashes, where I would feel flush and sweat. This makes me feel as if the room temperature is 150 degrees, no sweating. And I feel hot to the touch. I've been using ice packs to help alleviate, but that's not always practical."

9 / 10
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51 Report
  • DEE...
  • Taken for 10 years or more
  • January 15, 2021

"I began taking Duloxetine at age 61. I was well past menopause at that time. Serious hot flashes began and continue to this day at age 72. Doctors told me it was a side effect. I believe it is. What remedy could I use to combat flashes and still take Duloxetine?"

9 / 10
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28 Report
  • Anonymous
  • January 3, 2009

Duloxetine "I was prescribed 30mg Cymbalta 3 months ago to treat hot flashes/sweats. After just one pill, the hot flashes/sweats were gone. Before I was having 7-8 sweats per day. Going on 4 months now and the hot flashes/sweats are starting to slowly come back but they are still fewer than before. I want to keep taking and will have a recheck next month to see if I should increase to 60mg. All positive feedback so far."

9 / 10
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74 Report

Frequently asked questions

  • Jea...
  • Taken for 6 months to 1 year
  • October 8, 2016

"I have been taking Cymbalta for about six months. In the past few months, the hot feeling has increased greatly. I'm wondering if the Cymbalta is causing this. I know you can go on a decreasing dosage over a few weeks' period of time. Has anyone done this with success? I feel I'm at the end of the rope with feeling hot almost all of the time."

2 / 10
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42 Report
  • nyh...
  • August 1, 2012

Duloxetine "I started Cymbalta about 3 months ago for depression. At 30 mg, I was fine. We increased. They are worse than when I was going through menopause. My body is hot all the time. My feet are always hot and sweat. I don't want to stop the Cymbalta because it has had such a dramatic effect with the depression. I feel like me again mentally. I don't think these are listed as side effects."

7 / 10
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52 Report

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  • suz...
  • March 11, 2010

Duloxetine "I was prescribed Cymbalta for fibromyalgia. Not only did it not work for the fibromyalgia, but it restarted the hot flashes that had been under control! In doing research on fibromyalgia, I discovered that this drug has been reported to worsen hot flashes and other menopausal symptoms in women with fibromyalgia. If it works for you, many blessings!"

1 / 10
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59 Report
  • Sto...
  • Taken for 5 to 10 years
  • March 22, 2017

"I am a 53-year-old woman who took Cymbalta 90 mg/day for years (pain from spinal degeneration and arthritis). I ran out 6 weeks ago, and my doctor couldn't be reached to renew my prescription. I didn't feel very well for a few days, but then felt like I had before when I was taking Cymbalta (i.e., I realized it wasn't helping my pain), so I didn't restart it. I then began experiencing dreadful hot flashes and bed-drenching night sweats. After three weeks of this, I knew it wasn't Cymbalta withdrawal... the Cymbalta had been controlling what I just thought was a smooth-sailing menopause! I got my prescription refilled, but tried just taking 30 mg... and within days, the hot flashes and night sweats stopped. Very effective!"

9 / 10
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28 Report

More FAQ

  • Hot...
  • Taken for 2 to 5 years
  • April 18, 2016

"Complete hysterectomy 2003. Went through menopause with minimal hot flashes. Fast forward 2014-2016, started low dose Cymbalta for back pain after back surgery. Cymbalta seemed to help some with the pain. Dose increased to 40mg and eventually to 60mg. Hot flashes have been horrible. They come on fast, and there is nothing that makes them better except sitting with a fan blowing on me. I have heard bad stories about stopping Cymbalta and the side effects of that. I am fearful to stop, but too hot to continue."

3 / 10
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23 Report
  • Gra...
  • Taken for less than 1 month
  • April 4, 2019

"Began duloxetine for poor sleep and chronic back pain—cannot say that I had depression but have found mood improved. I am very delighted and surprised to find that back pain greatly improved, and I was able to go off my HRT without the vasomotor issues returning or insomnia that I have had in the past. Only downside is dry mouth and the sexual side effects—working through these. So far, so good."

9 / 10
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13 Report
  • Anonymous
  • May 11, 2012

"I have been dealing with severe hot flashes for 2 years. Once I started 30 mg of Cymbalta daily, the hot flashes immediately stopped. It has now been 2 months, and they are slowly returning, but they are milder than before."

8 / 10
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25 Report
  • Anonymous
  • Taken for less than 1 month
  • November 4, 2017

"Only been on this for a few days for menopause symptoms, and it is brutal. My doctor told me to take it at night, as it may cause drowsiness, but it kept me awake all night. The hot flushes were more frequent and worse, and I had nausea and diarrhea. And it made me very anxious, something I never had in my life. I'd advise extreme caution using this drug, and it is also meant to be extremely hard to wean off from."

1 / 10
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13 Report
  • Bon...
  • Taken for 6 months to 1 year
  • February 9, 2016

"After having 7-10 hot flashes a day... Waking up 2-3 times a night. My breast survivor MD prescribed me Cymbalta 10 mg daily. Hot flashes gone first day... Only an occasional warming now that I can handle."

10 / 10
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11 Report
  • Bee...
  • Taken for 1 to 2 years
  • February 14, 2022

"My hot flashes have all but disappeared on Duloxetine. I still get occasional night sweats, but highly recommend this as a treatment for hot flashes if, like me, you cannot tolerate hormone replacement. Side effects include dry mouth and some weight gain, but you can't win 'em all."

9 / 10
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1 Report
  • Ste...
  • Taken for 1 to 2 years
  • July 1, 2020

"I've been off for two months, and night sweats are still brutal! However, I have lost 6 of the 15 lbs!"

1 / 10
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7 Report
  • Nig...
  • July 25, 2021

"I was waking up five times a night, drenched in sweat."

9 / 10
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4 Report
  • lav...
  • Taken for 1 to 6 months
  • November 28, 2020

"I’ve been on Cymbalta for a month now, and the hot flashes are insane."

5 / 10
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5 Report
  • Liz...
  • Taken for 1 to 6 months
  • October 17, 2021

"2nd month of 30 mg, first two weeks, the nausea was awful, but overall pain relief for my fibromyalgia is amazing, but I can't stand the hot sweats, it's like a second menopause."

7 / 10
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4 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.

Learn more about Hot Flashes

Symptoms and treatments