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Duavee Side Effects

Generic Name: bazedoxifene / conjugated estrogens

Note: This page contains information about the side effects of bazedoxifene / conjugated estrogens. Some of the dosage forms included on this document may not apply to the brand name Duavee.

In Summary

More frequent side effects include: diarrhea, dizziness, muscle spasm, and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to bazedoxifene / conjugated estrogens: oral tablet

In addition to its needed effects, some unwanted effects may be caused by bazedoxifene / conjugated estrogens. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking bazedoxifene / conjugated estrogens:

Incidence not known:
  • Acid or sour stomach
  • anxiety
  • backache
  • belching
  • bloating
  • change in vaginal discharge
  • chest pain
  • chills
  • clear or bloody discharge from the nipple
  • confusion
  • constipation
  • cough
  • darkened urine
  • difficulty with speaking
  • dimpling of the breast skin
  • dizziness or lightheadedness
  • double vision
  • fainting
  • fast heartbeat
  • fever
  • full or bloated feeling or pressure in the stomach
  • headache
  • heartburn
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • indigestion
  • inverted nipple
  • loss of appetite
  • lump in the breast or under the arm
  • nausea
  • pain or feeling of pressure in the pelvis
  • pain, redness, or swelling in the arm or leg
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • persistent crusting or scaling of the nipple
  • redness or swelling of the breast
  • slow speech
  • sore on the skin of the breast that does not heal
  • stomach discomfort, upset, or pain
  • sudden shortness of breath or troubled breathing
  • swelling of the abdominal or stomach area
  • vaginal bleeding
  • vomiting
  • yellow eyes or skin

Minor Side Effects

Some of the side effects that can occur with bazedoxifene / conjugated estrogens may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Diarrhea
  • muscle spasm
  • throat pain
  • upper abdominal or stomach pain
Less common:
  • Neck pain

For Healthcare Professionals

Applies to bazedoxifene / conjugated estrogens: oral tablet


Frequency not reported: Venous thromboembolism, deep vein thrombosis[Ref]


Common (1% to 10%): Nausea, diarrhea, dyspepsia, upper abdominal pain[Ref]


Common (1% to 10%): Muscle spasms, neck pain[Ref]

Nervous system

Common (1% to 10%): Dizziness[Ref]


Frequency not reported: Retinal vein thrombosis[Ref]


Common (1% to 10%): Oropharyngeal pain
Frequency not reported: Pulmonary embolism[Ref]


The most common side effect were muscle spasms, nausea, diarrhea, dyspepsia, upper abdominal pain, oropharyngeal pain, dizziness, and neck pain.


1. "Product Information. Duavee (bazedoxifene-conjugated estrogens)." Pfizer U.S. Pharmaceuticals Group, New York, NY.

Not all side effects for Duavee may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.