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Duavee Side Effects

Generic Name: bazedoxifene / conjugated estrogens

Note: This document contains side effect information about bazedoxifene / conjugated estrogens. Some of the dosage forms listed on this page may not apply to the brand name Duavee.

In Summary

More frequent side effects include: diarrhea, dizziness, muscle spasm, and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to bazedoxifene / conjugated estrogens: oral tablet

Along with its needed effects, bazedoxifene/conjugated estrogens may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking bazedoxifene/conjugated estrogens:

Incidence Not Known

  • Acid or sour stomach
  • anxiety
  • backache
  • belching
  • bloating
  • change in vaginal discharge
  • chest pain
  • chills
  • clear or bloody discharge from the nipple
  • confusion
  • constipation
  • cough
  • darkened urine
  • difficulty with speaking
  • dimpling of the breast skin
  • dizziness or lightheadedness
  • double vision
  • fainting
  • fast heartbeat
  • fever
  • full or bloated feeling or pressure in the stomach
  • headache
  • heartburn
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • indigestion
  • inverted nipple
  • loss of appetite
  • lump in the breast or under the arm
  • nausea
  • pain or feeling of pressure in the pelvis
  • pain, redness, or swelling in the arm or leg
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • persistent crusting or scaling of the nipple
  • redness or swelling of the breast
  • slow speech
  • sore on the skin of the breast that does not heal
  • stomach discomfort, upset, or pain
  • sudden shortness of breath or troubled breathing
  • swelling of the abdominal or stomach area
  • vaginal bleeding
  • vomiting
  • yellow eyes or skin

Some side effects of bazedoxifene/conjugated estrogens may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Diarrhea
  • muscle spasm
  • throat pain
  • upper abdominal or stomach pain

Less Common

For Healthcare Professionals

Applies to bazedoxifene / conjugated estrogens: oral tablet


Frequency not reported: Venous thromboembolism, deep vein thrombosis[Ref]


Common (1% to 10%): Nausea, diarrhea, dyspepsia, upper abdominal pain[Ref]


Common (1% to 10%): Muscle spasms, neck pain[Ref]

Nervous system

Common (1% to 10%): Dizziness[Ref]


Frequency not reported: Retinal vein thrombosis[Ref]


Common (1% to 10%): Oropharyngeal pain

Frequency not reported: Pulmonary embolism[Ref]


The most common side effect were muscle spasms, nausea, diarrhea, dyspepsia, upper abdominal pain, oropharyngeal pain, dizziness, and neck pain.


1. "Product Information. Duavee (bazedoxifene-conjugated estrogens)." Pfizer U.S. Pharmaceuticals Group, New York, NY.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.