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Generic name: esterified estrogens and methyltestosteroneess-TER-ih-fied-ESS-troe-jenz-and-METH-il-tes-TOS-te-rone ]
Brand names: Covaryx, Covaryx HS, EEMT, EEMT HS
Drug class: Sex hormone combinations

Medically reviewed by on Jul 28, 2023. Written by Cerner Multum.

What is EEMT?

Esterified estrogens are female sex hormones produced by the ovaries.

Methyltestosterone is a sex hormone that is produced in a man's testicles. Small amounts of testosterone are also produced in a woman's ovaries and adrenal system.

EEMT is a combination medicine used to treat symptoms of menopause such as hot flashes or night sweats. EEMT is usually given only short-term (such as 3 to 6 months).

EEMT may also be used for purposes not listed in this medication guide.

EEMT side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

EEMT may cause serious side effects. Call your doctor at once if you have:

Methyltestosterone can cause symptoms of male features in a woman taking this medicine. Call your doctor if you develop enlarged genitals, male-pattern baldness, excessive body hair growth, increased acne, irregular menstrual periods, or any signs of male characteristics.

Common side effects of EEMT may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not use EEMT if you have: undiagnosed vaginal bleeding, severe liver disease, if you will have major surgery, or if you have ever had a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Do not use if you are pregnant or breastfeeding.

Estrogens may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Using this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, vagina, or liver. Estrogens should not be used to prevent heart disease.

Before taking this medicine

You should not use EEMT if you have:

Do not use this medicine if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Using this medicine can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.

EEMT should not be used to prevent heart disease or stroke because this medicine may actually increase your risk of developing these conditions.

Tell your doctor if you have ever had:

Using this medicine may increase your risk of cancer of the breast, uterus, vagina, or liver. Talk with your doctor about this risk.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

How should I take EEMT?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

EEMT is usually taken in a cycle of 3 weeks on and 1 week off. Follow your doctor's instructions.

Estrogens may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using EEMT.

Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms while taking EEMT.

When you stop using this medicine, follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea and vaginal bleeding.

What should I avoid while using EEMT?

Do not share EEMT with another person, even if they have the same symptoms you have.

What other drugs will affect EEMT?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect EEMT, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.