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User Reviews for Duloxetine to treat Osteoarthritis

Also known as: Cymbalta, Drizalma Sprinkle, Irenka

The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

Duloxetine Rating Summary

User Ratings
26% (8)
26% (8)
6% (2)
0% (0)
0% (0)
6% (2)
0% (0)
10% (3)
10% (3)
16% (5)
6.4/10 Average Rating
31 ratings from 34 user reviews

Compare all 190 medications used in the treatment of Osteoarthritis.

Reviews for Duloxetine

WSR · Taken for 1 to 6 months July 28, 2020

Cymbalta (duloxetine): “CYMBALTA changed my life. I started using Cymbalta for severe chronic lower back pain. My pain was so bad I considered suicide on many occasions. After failed back surgery, over the counter medications, epidurals, spinal ablation and everything else imaginable, my pain doctor prescribed Cymbalta. The side effects from Cymbalta were horrible, but within 2 weeks my back pain completely disappeared. I still deal with the side effects and Cymbalta is a highly addictive drug that is near impossible to withdraw from. I have come to terms with the alternatives and have decided Cymbalta is worth all of the negatives. It has saved my life.”

10 / 10
Anonymous · Taken for 1 to 2 years February 14, 2020

Cymbalta (duloxetine): “I was put on 60 mg of Cymbalta during an acute arthritis flare up, and after about a year I wanted to taper off of it. It killed my libido. and it didn’t significantly help with pain. Then the real nightmare began! Trying to go down in the tiniest increments brought on intense mood swings, crying for no reason, and horrible brain “zaps” that made life unmanageable. This stuff is TOXIC!!!!!!!”

1 / 10
Anonymous · Taken for 1 to 6 months September 23, 2019

Cymbalta (duloxetine): “Do not take Cymbalta! The side effects are horrible and the withdrawal symptoms from getting off of it can land you in the hospital. I took it for arthritis and would rather hurt then go through this garbage again. If I had known what damage this drug does I would never have taken it.”

1 / 10
PLW July 28, 2019

Cymbalta (duloxetine): “Love that I am pain free!”

10 / 10
Polarprince · Taken for 1 to 2 years July 18, 2019

Cymbalta (duloxetine): “This drug over time took away all emotional feelings. I could witness a accident and instead of being concerned I wasn't even phased. I found myself being cold and blunt with people. I was also suffering from crazy head and body sweats. Random but always severe. My Blood Pressure went through the roof. I lost ALL sexual desire to be with my wife or any woman. I'm blessed my wife stuck by me. Fatigue was also severe. I could sleep 12 hours and wake up feeling like I worked a 12hr midnight shift. After two years and age 43 I am starting to come off of it. My dose of 60mg has been reduced to 30mg and the sweating is gone, BP stabilized and energy returning. The main reason I suffered through the drug so long because it did help my Osteo. Right now is sooner suffer with pain and tend to my wife's physical needs like I once loved doing.”

3 / 10
grayfox · Taken for less than 1 month June 19, 2019

“I took my first (and last) duloxetine (Cymbalta) Monday night at about 11.00 pm with a light meal. After about 5 hours I started having stomach aches followed by severe nausea. I had dry heaves that left my stomach was very sore. Tuesday was spent in bed so tired that I thought I would never be able to get up. By Wednesday at about 9.00 am I was finally able to eat a slice of toast and some coffee. It is now about 6.00 pm and I still feel like I'm ready to fall down and I have shakes in my hands and sweat a lot. My doctor prescribed it for arthritis pain in my knee that had not responded to alternative treatments, rubs, laser , cortisone shot, etc. The duloxetine did stop the knee pain but it was a terrible trade off. Will be dumping this poison at my doctor's office tomorrow if I'm able to drive. I do NOT recommend this product. Too many serious side effects.”

1 / 10
Penny April 20, 2019

“I am a 61 year old women and I began taking duloxetine in January 2019 for osteoarthritis of the lumbar spine, hands, knees and feet. It clearly took the pain away. I then forgot to take the medicine for two days and the pain began to come back. I got back on track and the medicine began once again to take away the pain. Then in March I began getting hot flashes and sweating like never before. On April 20th after taking my 30 mg dosage, about an hour later I began to develop hip pain and took a 800 mg Motrin. I also had hot flashes and profuse sweating to the point that my pillow was soaked, my sheets and a towel were soaking wet. I really don’t know what to do at this point”

5 / 10
Astyanax · Taken for less than 1 month March 3, 2019

Cymbalta (duloxetine): “I was given Cymbalta 60mg for arthritis pain primarily and insomnia secondary. It had been recommended by both my oncologist and PCP. I felt awful the 5 days I took it. While there was a slight reduction in pain from a 4 to 3, I couldn’t eat. I woke up from restless sleep vomiting; I could have aspirated. I stopped immediately and had no side effects from doing so. The nausea was unbearable, and my anti-nausea meds were counter-indicated. Horrible experience. I gave a 2 rather than 1 due to slight pain reduction. I saw no improvement in sleep.”

2 / 10
QueenMamma · Taken for 6 months to 1 year May 21, 2018

“I am 31 and have had athritis in my spine since I was 24/25 I have taken may painkillers including Morphine but my body became to used to it and it stopped working. My doctor put me on duloxetine for the pain also for depression and this medication has changed my life. I'm able to be more active with my children. My depression has eased off and my mood had stabled completely. I take the tablets at night as it causes me to be drowsy so I get a good night's sleep as well so it is a win win”

9 / 10
MISSCLAIROL · Taken for less than 1 month April 10, 2018

Cymbalta (duloxetine): “I have never found an antidepressant that helps so well with arthritic pain management and generalized anxiety disorder. Very few side effects compared to other SNRIs , etc effexor. It has been a blessing for me so far. Have only been on it 2 weeks. Only side effect is a very slight nausea for about 15 minutes.”

9 / 10
Tasha1418 October 3, 2017

Cymbalta (duloxetine): “I have arthritis, neuropathy, fibromyalgia and depression. I have been taking Humira for my arthritis which caused heart failure. I had stopped taking the Cymbalta for a while because I was trying to cut back on medication. And I couldn't figure out why my arthritis felt so horrible as soon as I started to take the Cymbalta again my arthritis is so much better. It actually works better than the Humira did and better than the Lyrica that I am taking for my neuropathy. So I actually discovered how well it works accidentally. But it's so nice to be able to walk around again with so much less pain.”

10 / 10
Aunt Annie · Taken for 1 to 6 months July 24, 2017

“I never have had such a love/hate relationship with any drug. Started taking 2 months ago and experienced immediate side effects from throat all the way to my intestines along with headache. Side effects have decreased and I've tried going to 60 mg that lasted no more than 5 days before back to 30 mg. I keep waffling between continuing it or stopping it. Only happy days are those I don't take it. Positives are it decreased my osteoarthritis and neuropathy pain and reduced swelling of ankles. Side effects intensity changes often. This is really the drug from hell!”

Daisypop July 19, 2017

Cymbalta (duloxetine): “I've been in constant pain from osteoarthritis with some fibromyalgia on top of it for about two years and began taking cymbalta about 6+ weeks ago. I've been pain free for a month now with no need for any painkillers (I was taking a vicoden and tramadol every day during that time). Truly a miraculous recovery. Interestingly my doctor told me that his wife who had bad osteoarthritis pain had the same result from the cymbalta. Hope that it continues!”

10 / 10
Justajo · Taken for less than 1 month July 2, 2017

Cymbalta (duloxetine): “I started taking this med six days ago to treat neuropathy pain in my feet and lower legs. It, like gabapentin that I was taking before this, is giving me severe arthritis pain in my hands and knees, which I did not have before. I will discontinue the use today. It stopped the neuropathic pain but is crippling me in other ways. I will go back to treatments with NSAIDS and acetaminophen.”

3 / 10
life sucked November 30, 2016

Cymbalta (duloxetine): “I experienced chronic pain for 4 years, I had difficulty sleeping, would go to work, come home and go to bed. Every time I physically exerted myself, taking a shower, preparing a meal, doing household chores, I would need to go lay down. My family would visit me in my bedroom, it was depressing. Cymbalta has changed my life. I can tolerate the cold, even the grocery store used to bother me. I am much more active and find myself only going to bed when it is time for sleep, I also sleep much better. My family has noticed a huge change in me, as far as being a part of life again. This is not without cost..I have the strangest dreams, +30lbs, tired, terribly constipated.”

9 / 10
THOMAS O · Taken for less than 1 month April 29, 2016

Cymbalta (duloxetine): “Had severe arthritis, knees, hips,wrists, back below shoulder blades also middle in front left pectorial muscle, while in hospital dr gave me cymbalta, after 3 days pain level went from 7 down to about 2 1/2 . All pain gone from knees which were in constant pain no side effects that I have notice so far”

JFME · Taken for 1 to 2 years February 11, 2016

Cymbalta (duloxetine): “Tried Cymbalta for pain and slight depression. It helped for maybe 10 months. Then began experiencing panic attacks, anxiety, mouth sores, racing heart at bedtime, insomnia, and increased pain and cramps in legs. Took me about 3 months to figure out that the Cymbalta wasn't working. I tried increasing from 30 mg to 60 mg and that made it worse. Have changed meds. Made the change easily in one week, but I had already gone back to the 30 mg dose. The anxiety, panic attacks, etc. have stopped.”

1 / 10
Sunset Mami · Taken for less than 1 month January 6, 2016

Cymbalta (duloxetine): “Cymbalta has been a heaven sent. I have severe osteoarthritis in both knees and I'm 35. I stayed in chronic pain. On a 1-10 scale I was 76. This medication took my pain level to a 2. I couldn't believe how effective it was after 1 dose. I do suffer side effects such as nausea and diarrhea but I'm praying it passes. I've only been on the meds 3 days. I don't feel sidelined in life anymore. I can participate nearly pain free.”

9 / 10
Hipppie chic March 5, 2015

Cymbalta (duloxetine): “I suffer with arthritis in hands, knees, elbows, and hips. In 2013 I underwent a total left hip replacement and worked hard in rehab to become active again. However, as time progresses, my joints continue to 'talk' to me loudly. In the mornings, I look like a crone hobbling around until from moving they begin to become fluid. Ridiculous! My doctor put me on Cymbalta back in December of 2014. Wow. What a difference. I did have some struggles on learning when to take it without suffering with nausea, dizziness, etc. For me, morning time seems to be the ticket. Mid day or evening caused stomach and head issues. I am on a lower dose compared to what I have read, but I give this a A+. Within 15 minutes of taking my dose, I am fine.”

10 / 10
Mary Purvis · Taken for 1 to 2 years February 19, 2015

Cymbalta (duloxetine): “Relieve the pain in the joints in my wrists and hands, it was debilitating before my doctor put me on Cymbalta.”

10 / 10
trooperhg October 9, 2014

Cymbalta (duloxetine): “I was prescribed Cymbalta for anxiety but I have noticed that my osteoarthritis is so much better. I can get out of bed in the morning without hobbling around trying to get my joints working.I can also get up from my chair at work without pain.I am amazed at how much better I feel. Oh & it takes care of my anxiety as well.”

10 / 10
pjs001 August 6, 2014

Cymbalta (duloxetine): “I was prescribed Cymbalta for arthritic pain in my knees. I took 30 mg/day for 3 days and was fatigued to the point of not wanting to do anything but lie down.In addition (to which I found out was a rare side effect) I was yawning all day and evening. After reading about the difficulties that some people had getting off this medicine. I stopped it after the 3 days. Unless I can be somewhat assured that the side effects are temporary I would rather live with the pain then take this medicine.”

3 / 10
Sierra M. · Taken for 1 to 6 months March 5, 2014

Cymbalta (duloxetine): “This was great for pain relief for the two months I was taking it. The problems I had far out weighted any benefits. I was suffering from blackouts where I would do things and not remember doing them. The depression, nausea, and headaches were unbearable too. I have been off it for 2 months now and am just starting to feel better. I'll live with the on-average 8 pain.”

2 / 10
elaineabc · Taken for 2 to 5 years April 21, 2013

Cymbalta (duloxetine): “I was put on Cymbalta approximately 4 yrs ago for depression due to my spouses terminal illness. I was experiencing lower back pain at the same time and subsequently had surgery 2 yrs ago. During this time I tried to go off the medicine but discovered that I do have severe pain from osteoarthritis. Went back on Cymbalta and have almost complete relief from it. I take 60 mgs. at around 1:00 pm. Morning dosage brought diarrhea quickly and this does not cause that.”

8 / 10
Cricket's mom March 19, 2013

Cymbalta (duloxetine): “After a back injury and subsequent surgery I tried several medicines for the lingering nerve pain in my left leg. Nothing worked without severe side effects until trying Cymbalta. The first couple of weeks the nausea was almost unbearable but I toughed it out hoping for some relief of the aching in my left leg. Pain pills had zero effect on the radiating pain so my doctor prescribed Cymbalta. It did take a couple of weeks to see any relief to my pain. Although the pain is not totally gone it has gone from a 10 down to a 7 so for me this is a great improvement.”

8 / 10

Learn more about Osteoarthritis

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Symptoms and treatments Health Center

Mayo Clinic Reference

ICD-10 CM Clinical Codes (External)