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User Reviews for Duloxetine to treat Diabetic Peripheral Neuropathy

Also known as: Cymbalta, Drizalma Sprinkle, Irenka

Duloxetine has an average rating of 6.0 out of 10 from a total of 40 ratings for the treatment of Diabetic Peripheral Neuropathy. 58% of reviewers reported a positive effect, while 40% reported a negative effect.

Duloxetine Rating Summary

6.0/10 average rating

40 ratings from 43 user reviews.

Compare all 27 medications used in the treatment of Diabetic Peripheral Neuropathy.

10
23%
9
15%
8
20%
7
0%
6
0%
5
3%
4
0%
3
10%
2
3%
1
28%

Reviews for Duloxetine

Julles43 May 26, 2020

Cymbalta (duloxetine): “Took Cymbalta for severe nerve pain. (Hemangioblastoma removal inside spinal cord @ C4,5,6). It worked well for the pain and I had little side effects. Came to a point my doctor and I decided I didn’t need it anymore. Then the fun began. I don’t care what kind of issue you have or how much pain you are in - DO NOT TAKE THIS MEDICATION! Trying to get off this was the worst thing I could ever have imagined and it went on for months!! The list of symptoms was long and bizarre. I can’t stress enough how bad it was...please, please don’t take even 1. PS To Loulou: after being deathly ill for weeks I called my doctor, again, and they told me to just start taking it again and start tapering off again at another time! What?!? No frigging way so I suffered through almost six months of horrid withdrawal. It does go away, I promise! You aren’t alone - I felt EXACTLY the same way you do now! Hang in and do not start taking it again!! Good luck to you!”

1 / 10
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jesssikarmaa February 10, 2015

Cymbalta (duloxetine): “I was originally put on Cymbalta for depression, I was told to take it during the day which I did. When I took the Cymbalta during the day it made me incredibly sleepy to the point I could NOT stay awake so I discontinued it's use. Fast forward a few years and I started experiencing HORRIBLE Diabetic Peripheral Neuropathy. Doctor put me on Cymbalta to try and treat the pain. This time I took it before bed. I didn't notice any sleepiness during the day, and my nerve pain got better, and eventually was completely gone. After a year of use and almost no pain at all, I started having some "break through pain". Even though I am having "break through pain" after a year, the Cymbalta still makes life 100x better and I and grateful to have it!”

10 / 10
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Anonymous · Taken for 2 to 5 years January 27, 2016

Cymbalta (duloxetine): “I have been on Cymbalta for over 2 years. I have M.S. And am a type 1 diabetic with severe Neuropathy. Before this medication, the searing pain in my legs was unbearable. I could not walk because of it. I was originally put on gabapenton, and had such severe side effects that I quit taking it. My neurologist then prescribed me Cymbalta. He started me on a low dose, then after a month doubled it. Since then, I experience little to no pain. When I am a bit uncomfortable, I get in a warm bath and the pain is gone. I sleep better, have better control over my blood sugar as it does suppress appetite, but that means I am not munching or over eating. I can not live without it!!!”

10 / 10
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Anonymous · Taken for less than 1 month January 25, 2013

Cymbalta (duloxetine): “I’m a Type 1 Diabetic for 39 years. Had VERY painful muscle spasms/seizing and twitching. I tried various supplements which "should" have helped but no improvement. I started Neurontin at 1,800mg/day and I had terrible swelling plus gained 18 lbs in 6 months (and my eating habits actually got better while on it). The 1,800mg of Neurontin no longer controlled the muscle spasms. I started Cymbalta, 30 mg before bed, and had significant reduction in pain the first morning. I did notice a very strong headache that first day. I had only 3-4 muscle spasms that first day as well....Wow!! Second day...almost NO pain in the morning and only a dull headache with much weaker muscle spasms. Side effects: Crazy dreams, difficulty sleeping, headache.”

8 / 10
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Raz1959 August 5, 2016

Cymbalta (duloxetine): “I have been taking the drug for just a little over 3 weeks , I want a life membership for this Drug , I hardly have any pain , I can feel my feet and feel great on it , I am one of the lucky ones after reading many posts , i Have had nerve pain for almost 3 years and it has been brutal , I have tied amtatriplean , and lyrica , both did not wok , feeling way better”

10 / 10
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Potomac March 10, 2015

Cymbalta (duloxetine): “Excellent results with Cymbalta on 30mg once each night. Burning pain reduced some 80%. Does generate dreams, but not uncomfortable dreams. This is the first medicine that helped. Side effects too great with Neurontin; felt little to no effect with Lyrica.”

10 / 10
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Anonymous · Taken for 1 to 2 years September 14, 2012

Cymbalta (duloxetine): “I was not sure how well it worked at first. Then I was unable to get it for awhile, and was in a lot of pain, trouble getting through the day. I just wanted to sleep. Once back in my system I noticed the difference. This helps my depression, back pain, and the neuropathy.”

9 / 10
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Frequently asked questions

hmmmmmmmmm October 4, 2017

Cymbalta (duloxetine): “I have taken Cymbalta for 12 years for Peripheral Neuropathy. The prior 15 years I had what felt like a million little electric eels burrowing just under the skin of my right thigh. Or it felt like my thigh was packed in ice. For 15 years I was blown off by every doctor I saw under my insurance. A Dr not covered by my insurance prescribed Cymbalta. I had an immediate improvement, which just kept getting better. 0 side effects. A year in and things unrelated to the neuropathy improved dramatically. A hand tremor went away, I no longer fell a lot. Eventually Kaiser would cover the Generic, which makes me throw up.”

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Amoya81 · Taken for 1 to 6 months September 8, 2017

Cymbalta (duloxetine): “I'm a recovering alcoholic of 16 years. I was diagnosed diabetic in 2008 and continued drinking until May 7th 2017. Unfortunately my addiction had caused a lot of damage to my body that I didn't notice while consuming 3-6 gallons of beer a day. In the past if I didn't have a drink I would start to feel pain in my legs so I drank more. Now after the first I weeks and the shakes went away I went to a doctor to get my health checked. After fully disclosing my situation he prescribed gabapentin.. I had a bad skin burring reaction after a few weeks and my legs and feet were like lighting storms of pain. He then prescribed Cymbalta. I was reluctant at first reading all the side effects. But now I take it 2 hours before bed and the pain is gone.”

8 / 10
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KimberDawn38 July 25, 2009

Cymbalta (duloxetine): “I've tried many, many different medicines for my nerve pain. Finally after being put on Cymbalta for my depression, I noticed that my nerve pain was not near as bad as it was before. I'm overwhelmed with my results. Almost to tears, of joy, instead of tears of pain! Thank you!”

10 / 10
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Ssanders261 · Taken for less than 1 month December 4, 2016

Cymbalta (duloxetine): “I've been on Cymbalta/30mg for 1 week. Strong diarrhea first night, missed work the next day. Since then little trouble sleeping, napping on my days off. I work 12 hr shifts on my feet on a cement floor. I lost the feeling in my toes almost a year ago. Dealt with the hot coals burning on the bottom of my feet also. In such a short length of time I have had some relief in the burning of my soles and with the back pain. Hoping for continued improvement”

8 / 10
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Frosty · Taken for 2 to 5 years June 11, 2019

Cymbalta (duloxetine): “Diagnosed with Idiopathic Small Nerve fiber neuropathy and eventually put on Cymbalta. 60 mg daily. Been taking it for 5 years. First week was difficult but my Neurologist encouraged me to soldier through. Relief began after about the 5th day. My main complaint is fatigue. On the upside, I sleep like a teenager. I’m retired so I can sleep in. I don’t think I would be able to work on this though. Recently, I discovered I can get by with 60 mg every other day. That’s what brought me here. Looking for info about that. I have an appointment with my Neurologist in July and wanted more info before I discuss my condition”

10 / 10
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MJ · Taken for 1 to 6 months August 30, 2019

Cymbalta (duloxetine): “I've been taking Cymbalta for 6 months 20 mg once a day it has helped with my neuropathy in my legs but nothing has stopped it so it's better than taking nothing which causes pain that is unbearable. But when taking the 60 mg it has me very nauseated and off balance. So I have not been able to take a larger amount, then 20 mg a day. I tried taking it at night but I was really restless oh, so I take it in the morning with food.”

8 / 10
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Jo.Nigle October 27, 2009

Cymbalta (duloxetine): “Cymbalta was the first drug that actually improved the diabetic neuropathy pain I was experiencing in my legs, feet, arms and hands. For the first time, I was able to sleep through the night without waking in tears from the pain. I was so happy my doctor put me on this drug in conjunction with Neurontin. The pain almost disappeared! Approximately 6-8 weeks later, I noticed that the neuropathy pain started back up again despite continuing on the medicines. I too, had insomnia making it difficult, at best, to be alert, focused or have any energy the following day. To this day, I still have some insomnia and an increase in the neuropathy symptoms; BUT Cymbalta 60mg & Neurontin 600mg are the BEST drugs so far in lessening the pain.”

9 / 10
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Anonymous February 1, 2010

Cymbalta (duloxetine): “I have peripheral neuropathy and very bad pain in my back. Cymbalta made a huge improvement in my pain level. The doctor started me gradually to lessen the nausea. I have worked up to 30 mg. twice a day for a total of 60 mg. I have been taking it for 3 months and still find the pain level, and my frame of mind, much improved. I do have slight nausea occasionally, and dry mouth. The excessive sweating has gone away.”

8 / 10
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Kitty · Taken for less than 1 month November 28, 2020

Cymbalta (duloxetine): “Horrible. Made my stomach upset, groggy, nausea, anxiety worse. After one day!!!I can't handle it. I can't believe how hard it is to find decent pain relief. Inhumane to keep someone alive with nerve pain.”

1 / 10
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samitarvian October 14, 2015

Cymbalta (duloxetine): “I was on Cymbalta for a few years, and over that time, I didn't notice a significant reduction in the pain, but I did notice that my memory started to diminish. I asked my doctor to take me off of it, but he refused, so I quit cold-turkey. The side effects are significant and severe! I wouldn't suggest this tactic! All in all, I'm very happy to be off of it... my memory is improving noticeably, and the foot pain is just about the same.”

3 / 10
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Justme22 · Taken for 1 to 6 months October 15, 2017

Cymbalta (duloxetine): “Was prescribed 20mg of this when my hands started burning, which caused me more anxiety than the idiopathic nerve damage in my feet that was detected on an EMG. Feeling much less anxious, NO nerve pain in my hands, and 80-90% less tingling/vibrating in my feet. The first week on this I had severe headaches in the morning, which I pushed thru and didn't have after about 10 days. I feel noticeably less energetic and groggy in the morning than I used to. Other than that, I haven't noticed any side effects, and I usually react to medications (which makes me cautious). I am not on ANY other meds. I would rate this a 10, but the awful headaches in the morning were a pain and feeling groggy until noon-ish is tolerable but not ideal.”

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FuzzyDunlop · Taken for less than 1 month June 6, 2019

Cymbalta (duloxetine): “Joined this website solely to warn others that the side effects of Cymbalta were worse than any other med ever. After taking for 10 days nearly all the side effects that others mention were experienced, after stopping the scariest pains were felt down the middle of left arm and less down the right, groin pain radiating down the left leg and less down the right and the feeling someone was pushing their thumb into my neck on my jugular.”

1 / 10
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Billiejeanhampton · Taken for 10 years or more August 7, 2017

Cymbalta (duloxetine): “I have taken 60mg for 20 years. Three weeks ago my Dr. dropped the dosage to 30 mg. I had some hateful and days of crying. Now that passed but my feet and legs and lower back hurt so bad I can barely walk. Is this normal and would it stop if I took 60 again.”

9 / 10
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dyot · Taken for 1 to 6 months December 8, 2015

Cymbalta (duloxetine): “Not diabetic neuropathy, but neuropathic pain nonetheless. Works wonderfully... ...except for the terrible acne it's causing, and the relatively frequent but terrible headaches. I also have some issues with anxiety; it has done exactly nothing of use there.”

8 / 10
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Anonymous · Taken for 1 to 6 months March 25, 2018

Cymbalta (duloxetine): “I’ve been taking 30 mg a day for a few months, prescribed partly for depression but mainly for neuropathy. I’ve noticed a marked reduction in pain, a minimal positive effect on depression but the skyrocketing anxiety is crazy. It seemed to actually decrease anxiety for about a week, then went in the opposite direction. I asked my doctor about this, and discontinuing it, but he said not to, and instead go to 60 mg. This has put me in an awkward position of noncompliance (for good cause IMO). Ultimately though, I guess it’s my responsibility. If I don’t notice a decrease in the anxiety soon I’ll be stopping Cymbalta. No sense in paying a doctor to feel worse!”

3 / 10
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hemaro April 6, 2009

Cymbalta (duloxetine): “Cymbalta has been a lifesaver for my Diabetic Neuropathy. In just a few days the pain and discomfort went away. The only problem I am facing with Cymbalta is insomnia even in combination with Xanax 4mg and Vistaril 150mg.”

9 / 10
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Anonymous June 9, 2009

Cymbalta (duloxetine): “Debilitating side effects after only 2 hours with only one 60mg pill. Extreme sweating, fatigue, difficulty swallowing and walking. Next came the nausea and intense insomnia. Had to call in sick to work the next day due to lack of sleep and weakness. Didn't get out of bed until 3 pm.”

1 / 10
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TerryinAlaska October 20, 2009

Cymbalta (duloxetine): “It was like a wonder drug at first. Then, even though I went up to the maximum dose of 60 mg, I can no longer tell I am even taking it. I stop it - then start it back up - still no help. It's just no good anymore.”

3 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

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