User Reviews for Duloxetine
Also known as: Cymbalta, Irenka
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
Learn more about Duloxetine.
Reviews for Duloxetine to treat Diabetic Peripheral Neuropathy
Cymbalta (duloxetine): "I have taken 60mg for 20 years. Three weeks ago my Dr. dropped the dosage to 30 mg. I had some hateful and days of crying. Now that passed but my feet and legs and lower back hurt so bad I can barely walk. Is this normal and would it stop if I took 60 again."
Billiejeanhampton (taken for 10 years or more) August 7, 2017
0 users found this comment helpful.
Cymbalta (duloxetine): "I"ve been taking cymbalta for 10 years for neuropathy. I didn't know how effective it was until I decided to stop taking it. My foot felt as if it were in hot coals. I love it."
Dunn405 January 23, 2017
17 users found this comment helpful.
Cymbalta (duloxetine): "I've been on Cymbalta/30mg for 1 week. Strong diarrhea first night, missed work the next day. Since then little trouble sleeping, napping on my days off. I work 12 hr shifts on my feet on a cement floor. I lost the feeling in my toes almost a year ago. Dealt with the hot coals burning on the bottom of my feet also. In such a short length of time I have had some relief in the burning of my soles and with the back pain. Hoping for continued improvement"
Ssanders261 (taken for less than 1 month) December 4, 2016
16 users found this comment helpful.
Cymbalta (duloxetine): "I have been taking the drug for just a little over 3 weeks , I want a life membership for this Drug , I hardly have any pain , I can feel my feet and feel great on it , I am one of the lucky ones after reading many posts , i Have had nerve pain for almost 3 years and it has been brutal , I have tied amtatriplean , and lyrica , both did not wok , feeling way better"
Raz1959 August 5, 2016
27 users found this comment helpful.
Cymbalta (duloxetine): "I have a amputated left arm I have horrible nerve pain ,the doctor I just saw started me on cymbalta I have only been on it a week and have not noticed any different yet how long does it take for it to work?"
No Arm (taken for less than 1 month) July 11, 2016
3 users found this comment helpful.
Cymbalta (duloxetine): "Sort of worked but I was sleeping all the time. 12 - 14 hours per day and then could not move the rest of the day. Had to stop after 10 days of being a zombie."
No Nickname May 28, 2016
13 users found this comment helpful.
Cymbalta (duloxetine): "Made me sick first day nausea , dizzy, vomit, sweating, high blood pressure"
Lisa0617 March 7, 2016
12 users found this comment helpful.
Cymbalta (duloxetine): "I have been on Cymbalta for over 2 years. I have M.S. And am a type 1 diabetic with severe Neuropathy. Before this medication, the searing pain in my legs was unbearable. I could not walk because of it. I was originally put on gabapenton, and had such severe side effects that I quit taking it. My neurologist then prescribed me Cymbalta. He started me on a low dose, then after a month doubled it. Since then, I experience little to no pain. When I am a bit uncomfortable, I get in a warm bath and the pain is gone. I sleep better, have better control over my blood sugar as it does suppress appetite, but that means I am not munching or over eating. I can not live without it!!!"
Anonymous (taken for 2 to 5 years) January 27, 2016
45 users found this comment helpful.
Cymbalta (duloxetine): "Not diabetic neuropathy, but neuropathic pain nonetheless. Works wonderfully... ...except for the terrible acne it's causing, and the relatively frequent but terrible headaches. I also have some issues with anxiety; it has done exactly nothing of use there."
dyot (taken for 1 to 6 months) December 8, 2015
18 users found this comment helpful.
Cymbalta (duloxetine): "I was on Cymbalta for a few years, and over that time, I didn't notice a significant reduction in the pain, but I did notice that my memory started to diminish. I asked my doctor to take me off of it, but he refused, so I quit cold-turkey. The side effects are significant and severe! I wouldn't suggest this tactic! All in all, I'm very happy to be off of it... my memory is improving noticeably, and the foot pain is just about the same."
samitarvian October 14, 2015
23 users found this comment helpful.
Cymbalta (duloxetine): "Excellent results with Cymbalta on 30mg once each night. Burning pain reduced some 80%. Does generate dreams, but not uncomfortable dreams. This is the first medicine that helped. Side effects too great with Neurontin; felt little to no effect with Lyrica."
Potomac March 10, 2015
41 users found this comment helpful.
Cymbalta (duloxetine): "I was originally put on Cymbalta for depression, I was told to take it during the day which I did. When I took the Cymbalta during the day it made me incredibly sleepy to the point I could NOT stay awake so I discontinued it's use. Fast forward a few years and I started experiencing HORRIBLE Diabetic Peripheral Neuropathy. Doctor put me on Cymbalta to try and treat the pain. This time I took it before bed. I didn't notice any sleepiness during the day, and my nerve pain got better, and eventually was completely gone. After a year of use and almost no pain at all, I started having some "break through pain". Even though I am having "break through pain" after a year, the Cymbalta still makes life 100x better and I and grateful to have it!"
jesssikarmaa February 10, 2015
61 users found this comment helpful.
Cymbalta (duloxetine): "Can't live without it"
Momma 1234 July 7, 2014
49 users found this comment helpful.
"Causes erectile dysfunction, and raises blood sugar x 2 times.."
JosephRu (taken for 1 to 6 months) June 18, 2014
3 users found this comment helpful.
Cymbalta (duloxetine): "Increases blood sugars. x 2 higher than when not taking it."
RobinSS (taken for 2 to 5 years) January 2, 2014
32 users found this comment helpful.
Cymbalta (duloxetine): "I’m a Type 1 Diabetic for 39 years. Had VERY painful muscle spasms/seizing and twitching. I tried various supplements which "should" have helped but no improvement. I started Neurontin at 1,800mg/day and I had terrible swelling plus gained 18 lbs in 6 months (and my eating habits actually got better while on it). The 1,800mg of Neurontin no longer controlled the muscle spasms. I started Cymbalta, 30 mg before bed, and had significant reduction in pain the first morning. I did notice a very strong headache that first day. I had only 3-4 muscle spasms that first day as well....Wow!! Second day...almost NO pain in the morning and only a dull headache with much weaker muscle spasms. Side effects: Crazy dreams, difficulty sleeping, headache."
Anonymous (taken for less than 1 month) January 25, 2013
73 users found this comment helpful.
Cymbalta (duloxetine): "I was not sure how well it worked at first. Then I was unable to get it for awhile, and was in a lot of pain, trouble getting through the day. I just wanted to sleep. Once back in my system I noticed the difference. This helps my depression, back pain, and the neuropathy."
Anonymous (taken for 1 to 2 years) September 14, 2012
57 users found this comment helpful.
Cymbalta (duloxetine): "Did not work for me. I had nausea, abdominal & stomach pain, loss of appetite. I lost 5 lbs. in less than a week."
Anonymous August 12, 2012
41 users found this comment helpful.
"I have severe Diabetic Neuropathy to both feet, and Neurotin seemed rather ineffective. The pain was a combination of burning, needles and pins sensation, and severe knife stabbing sensations intermittently to both feet. I started taking Cymbalta over a year ago, and it has significantly reduced the sensations and pain, making them tolerable. I initially noticed a loss of appetite, which was a blessing in disguise for me, and I lost 25 pounds before the anorexia disappeared. I have several severe disorders which require close monitoring of my blood, but overall, Cymbalta has been a God send to me."
Tonywwk1 March 23, 2012
4 users found this comment helpful.
Cymbalta (duloxetine): "I started on 30mg Cymbalta daily with a little foot pain improvement - as this was still not enough my doctor put me on 60mg daily. I am so happy and relieved to be able to actually "walk" again and function like a normal person. I was crawling to the bathroom at night before for 8 months I was in pure agony. I have been on Cymbalta for 5 weeks and so far great results! Thank you Eli Lilly and my doctor."
Sewanhaka100 February 18, 2012
85 users found this comment helpful.
Cymbalta (duloxetine): "Cymbalta lessens the burning pain in my feet that used to wake me up and keep me awake at night. It often relieves burning pain almost completely."
Anonymous September 6, 2010
68 users found this comment helpful.
Cymbalta (duloxetine): "I was very unsteady on my feet, at first some of the pain was resolved, but it didn't work. Even though my feet were NOT swollen they felt that way, very tight feeling. It felt like I was walking on balloons, terrible feeling and I was afraid to walk with that unsteadiness. Didn't work for me, since then, I have been on many different medications. Neurontin, didn't help, amitriptiline, didn't help, Lyrica, didn't help. I am on nortriptyline now with a pain patch. The fentanyl patch really helps, but I don't want to stay on this forever, so trying different medications. I am only supposed to leave the pain patch on 3 days, and found with the new medication, nortriptyline, I can go 5 days. So I am hopeful here. "
kathygirl August 6, 2010
21 users found this comment helpful.
Cymbalta (duloxetine): "I have peripheral neuropathy and very bad pain in my back. Cymbalta made a huge improvement in my pain level. The doctor started me gradually to lessen the nausea. I have worked up to 30 mg. twice a day for a total of 60 mg. I have been taking it for 3 months and still find the pain level, and my frame of mind, much improved. I do have slight nausea occasionally, and dry mouth. The excessive sweating has gone away."
Anonymous February 1, 2010
56 users found this comment helpful.
Cymbalta (duloxetine): "Cymbalta was the first drug that actually improved the diabetic neuropathy pain I was experiencing in my legs, feet, arms and hands. For the first time, I was able to sleep through the night without waking in tears from the pain. I was so happy my doctor put me on this drug in conjunction with Neurontin. The pain almost disappeared! Approximately 6-8 weeks later, I noticed that the neuropathy pain started back up again despite continuing on the medicines. I too, had insomnia making it difficult, at best, to be alert, focused or have any energy the following day. To this day, I still have some insomnia and an increase in the neuropathy symptoms; BUT Cymbalta 60mg & Neurontin 600mg are the BEST drugs so far in lessening the pain."
Jo.Nigle October 27, 2009
58 users found this comment helpful.
Cymbalta (duloxetine): "It was like a wonder drug at first. Then, even though I went up to the maximum dose of 60 mg, I can no longer tell I am even taking it. I stop it - then start it back up - still no help. It's just no good anymore."
TerryinAlaska October 20, 2009
31 users found this comment helpful.
More about duloxetine
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 1297 Reviews – Add your own review/rating
- Drug class: serotonin-norepinephrine reuptake inhibitors