Skip to Content

User Reviews for Plaquenil to treat Rheumatoid Arthritis

Plaquenil has an average rating of 7.0 out of 10 from a total of 58 ratings for the treatment of Rheumatoid Arthritis. 55% of reviewers reported a positive effect, while 19% reported a negative effect.

Plaquenil Rating Summary

7.0/10 average rating

58 ratings from 66 user reviews.

Compare all 304 medications used in the treatment of Rheumatoid Arthritis.

10
22%
9
17%
8
16%
7
12%
6
7%
5
3%
4
3%
3
9%
2
0%
1
10%

Reviews for Plaquenil

Hot Dog · Taken for 10 years or more May 20, 2020

“I am 76 year old female with Rheumatoid Arthritis for about 40 years. I have been on Plaquenil for about 30 years which has controlled pain and swelling of joints. X-rays have shown decrease in joint destruction. I have multiple drug reactions but have had none with Plaquenil. I do have occasional flare in rainy, cold weather which is gone in about 2 days with anti-inflammatory. I see my ophthalmologist once a year for extensive eye exam. To date no problem. Very, very pleased with Plaquenil and love my Rheumatologist.”

10 / 10
Was this helpful?YesNo
Mike · Taken for 6 months to 1 year August 4, 2019

“It started as Palindromic Arthritis, then progressed to full fledged RA with frequent flares attacking my shoulders, elbows, wrists, knees and even my jaw. Most attacks would severely limit my physical abilities. The doctor suggested Humira, I was little reluctant - too many side effects to think about. She said we could try Plaquenil - a milder drug. I was told it takes two months before patients feel any improvement, it took little less for the drug to kick in. Now, it's been a year - I have no flares, no pain and no side effects I can think of. I take one pill in the morning, one in the evening. This drug works well for me.”

10 / 10
Was this helpful?YesNo
TJT1 January 22, 2016

“I have been on Plaquenil since 1996 when I was diagnosed with RA. When I was diagnosed I was in severe pain, unable to hold my infant child or drive. My rheumatologist injected me with steroids to get me immediate relief and started me on Plaquenil. I don't remember my initial dosage but I take 200mg once per day and have been in remission since 1996 and I have had no side effects that I am aware of. I have regular eye exams and periodic screenings by a retinologist and my eyes have had no issues at all.”

10 / 10
Was this helpful?YesNo
Ace · Taken for 10 years or more May 14, 2019

“Hi, I was taking the generic form of plaquenil for over 10 years for rheumatoid arthritis. It took a few weeks to see it work but what a change for the better. Less painful joints and fatigue. Always have gotten retina checked and have been good. Then I started getting debilitating migraines. I went off my meds one by one and the GENERIC was to blame. My pharmacy switched to another foreign cheap manufacturing co. My doctor told me many generics change their fillers which cause side effects. Since I’ve been off I have declined rapidly. I’m trying to find assistance for original brand. It’s outrageous that we are forced to get generics! Especially if a person has a reaction we should be able to get brand at same or reasonable prices. Which they are not. This drug was so helpful for me and its worth a try, give it 2-6 months. Good luck!”

10 / 10
Was this helpful?YesNo
Anonymous November 10, 2019

“Hi all. Been on Plaquenil for 30 years for rheumatoid arthritis. I don’t know if I have side effect from this drug as they are intermittent... Itching - weird times not consistent Eye watering - constant Headaches - hormonal, RA related Always had thin hair - never fell out No stomach issues ever Get eyes checked 1x a year. My eye dr puts me through an hour+ battery of tests (4?) and takes a picture of my eye every year (cool machine ... don’t have to dilate). Blood work every three months to monitor kidneys. Starting to wonder if I need to increase because my shoulders starting to loose range of motion and had bursitis a few weeks ago in one. Or maybe I need to increase prednisone (also 30 years - 5 mg once a day).Been off the anti-inflammatory diet though ... will get back on it, too. Starting gym on Tuesday .... Stay healthy folks!”

10 / 10
Was this helpful?YesNo
Daughter #5 · Taken for 1 to 6 months December 21, 2012

“My 19 yr old daughter was diagnosed with rheumatoid arthritis this past year...her inflammation markers were off the charts. She took meloxicam for a couple of months, but it really hurt her stomach to where she couldn't eat. They put her on Plaquenil about 6 months ago...she is doing great. Recently had blood work and her inflammation is almost all gone...no side effects for her. I hope this medicine can help other people.”

10 / 10
Was this helpful?YesNo
Kat019 · Taken for 1 to 6 months March 3, 2017

“I began taking Plaquenil for RA 1 month ago. Despite information from my doctor that it would be at least 3 months before I see an appreciable effect, I am feeling better than I have in the last year. Prior to Plaquenil, I tried Mobic & Medrol, both with limited improvement. But over the last few weeks I have been able to play basketball with my son again, move without thinking or a 'warm up period', return to the gym, begin Pilates & I've lost 12 pounds! I did have some GI upset over the last month, but nothing I would consider stopping this medication for. I am able to enjoy things again & live life without discomfort.”

9 / 10
Was this helpful?YesNo

Frequently asked questions

geezergirl September 5, 2016

“I've been on this drug since 2003. Before meds, I was so sick with RA symptoms. Spent 19 hours a day in bed, couldn't dress or bath myself. Seldom ate. Doctor put me on 200 mg. plaquenil twice daily and 10 mg. prednisone and I got my life back. I've since drop prednisone and am down to 200 mg. once daily plaquenil. About to go on the generic form of plaquenil. A little concerned. Is the quality the same? My specialist said no. RA drugs are so scary. I've had friends die on biologics--and some go blind. My advice as geezergirl. When you find out what works for you, hold on tight to it.”

10 / 10
Was this helpful?YesNo
Darkchief99 June 6, 2017

“Haven't taken this. Just wanted to read some feedback. I was on methotrexate, but stopped, because it gave me chills, fatigue and shortness of breath, I even fainted at work. The doctor suggested Plaquenil as a possible alternative, but after reading some of the comments, I don't think so. This is really frustrating and sad. The FDA should NOT be approving these crappy drugs which can cause worse problems than the one you have. I honestly don't know what to do, let the RA turn me into a cripple or take my chances with one of these death drugs?”

Was this helpful?YesNo
RichEsq April 13, 2017

“Love this drug, compared to the others. I am 55 now, and first took it 30 years ago. My RA then came on lightening fast, nodules and all. I went from totally normal to almost wheel chair in weeks. The weight of a bed sheet on my toes was too much. Two plaquenil a day and 2400 mg of ibuprofen a day ( that's 12 regular dose!) and I went into total remission. Of course my stomach is crap now. After 25 years of remission, the RA returned. Different now that I'm older (55), more subtle. Chose plaquenil again, and working wonders, but for my permanent damage. Get your eyes checked, a must. Some hair will fall out, but hey, I'm glad I still have some to fall out. WEIRD dreams. Irritability. Will lose weight! TAKE WITH FOOD to avoid cramps.”

Was this helpful?YesNo
Enz · Taken for 2 to 5 years February 15, 2018

“Well I posted once before, figured I would give another update for anyone who cares. It's been around 2 years now and I'm glad to say all side effects are long gone. So is my pain for the most part. Sometimes I forget I was even diagnosed with RA (Palindromic Rheumatism). Every once in awhile I will have a flare, my last one was in October of last year 2017, it is now Feb 2018 and still flare free. I've been seeing gaps of 6+ months without any pain. You can see why it's easy to forget lol. Again, this drug is worth it. It seems almost like a dream waking up and not being able to move, a horrible dream.”

10 / 10
Was this helpful?YesNo
KittensAussiePrincess March 26, 2017

“I've been on Plaquenil for over 3 months now. It works wonderfully! I combine my treatment with Curcumin & Magnesium baths and I feel like a new woman :-) Side effects I experienced: Nausea & dizziness for the first week or two (I found I needed to take it after a full meal to prevent the nausea). I have also noticed since starting the Plaquenil I seem to sweat profusely. It's annoying, but the benefits far outweigh this little problem. I just wear my gym gear about now... which I did mostly beforehand anyhow :-) Also, it take take a couple months for the Plaquenil to kick in & for me to feel the effects! Don't give up, just give it some time.”

7 / 10
Was this helpful?YesNo
Holly November 13, 2018

“I've been on a roller coaster for yrs w/Plaquenil for RA/Lupus. I take name brand to prevent side effects of red, warm, swollen, painful hands + nausea/dizziness, hair loss, etc. Each time I try going back to generic, side effects return immediately. I'm not one to comment but I read so many reviews that sounded like either my ups or downs, so I want to encourage ppl to stick w/this med & try name brand (though expensive) if having bad side effects w/generic. It could explain why some ppl have such opposite experiences. I get Plaquenil from international pharm & it's much cheaper. It works better than biologics that contributed to/sped up process leading to my cancer. I'm now "cancer-free" & refuse to go back on them. I might have to get vision checked & deal w/other mild side effects, but pain/swelling is gone on Plaquenil. Anyway, pls hang in there & give your body enough time to adjust to med before stopping it. It's a risk vs. reward scenario w/meds.”

9 / 10
Was this helpful?YesNo
The Law · Taken for 1 to 6 months July 2, 2013

“I was told that I have rheumatoid arthritis a few months back. I have been on Plaquenil now for almost 2 months. It has helped with the pain in my hands and feet. I still have swollen fingers but am waiting for the full affects of the drug. I do not know how common this is but the side effect that I am having is hair loss. I am guessing it wouldn't be as bad if I was a male but being a female. I am hoping this stops after my body gets used to the medicine because I am very discouraged with that aspect.”

7 / 10
Was this helpful?YesNo
Enz · Taken for 1 to 6 months July 25, 2016

“I started on Plaquenil for RA about two months ago so my experiences are fresh. I'm a large male at 6'2 250 pnd 30 years old. When I was diagnosed with RA I didn't know what to expect. I was quickly referred to a Rheumatologist who recommended this drug. The first three weeks I was having some side effects. Nose bleeds, ringing in my ears. But after the fourth week they just disappeared. As well as the excruciating pain in my feet, knee's and hands. It just poof like it never happened. I'm optimistic about now my third month as it has now been three months since my last flare up. It was too late for my feet, which now have permanent damage, but I can now walk and wear shoes almost perfectly normally.”

9 / 10
Was this helpful?YesNo
cjgriff · Taken for 10 years or more October 27, 2015

“This medication did wonders for my soreness and pain from Rheumatoid Arthritis but if someone would have told me I would have devastating and irreversible eye damage due to taking it, I would have chosen a different drug for sure (at least after the 5-7 year mark when it is known to cause major problems that will be with you for life!)”

3 / 10
Was this helpful?YesNo
ithasaname September 9, 2019

“Hi I am a 63 year old female who was diagnosed with RA after instigating a blood test for it out of desperation 3 weeks a go. My debilitating chronic pain in feet and random knee flare ups has a name. My rheumatologist put me on prednisolone ( reduced doses over in 3 months ) until the methotrexate starts working (once a week of 15mg for 2 weeks , 20mg once a week indefinitely). Plaquenil 300mg daily. I also take Vit D daily and 5mg folic acid once a week plus curcumin and fish oil I have been taking it all with breakfast for the last 8 days . I have had stomach cramps but no diarrhoea The prednisolone has been magic for pain free sleep and movement. will see in 2 months time with only the latter 2 . Trying to stay positive with yoga and strength exercises Drugs , vitamins ,anti-inflammatory supplements , eye tests and blood tests and maybe a nice wig are now part of my new reality”

8 / 10
Was this helpful?YesNo
cherired July 9, 2015

“I had very bad experiences with this medication . I now have permanent toxicity of my system and I also develop medically induced cataracts from this medication even though I have stopped taking the medication it will continue to try and rob me of my sight. eyes always swollen running very painful. every morning when I rise I look like a monster face full of fluid input all around my eyeslike a little Sacks of fluid. is there is help out there I would like some and I will like to know if there's a manufacturer lawsuit the information for this medication does not tell you about the damage that it does. now they are warning doctors to let patients know about this medication and the bad side effe and let them know if they want to take it.”

1 / 10
Was this helpful?YesNo
peanut61 · Taken for 2 to 5 years April 16, 2013

“I had very few side effects with this medicine in the beginning, but it didn't provide enough relief on days when I had to be on my feet for a few hours a day. It didn't remove all inflammation so I was taken off and tried on methotrexate, a lot worse side effects and no relief at all. I had no vision changes with Plaquenil and I would much rather have some relief than none. I was able to function with minimum pain with Plaquenil.”

7 / 10
Was this helpful?YesNo
langteach · Taken for 6 months to 1 year October 28, 2015

“Started Plaquenil 8 months ago-200mg 2x/day- to treat Psoriatic arthritis and sjogrens. Learned to NOT take it in the morning with my Meloxicam 15mg because of strong nausea. If I take one after a big lunch and one after dinner, I have no problems at all. Joints and hands, wrists are doing so much better. One worry is that I am too tired to do anything at all. If I do laundry, I sweat. If I cook dinner or rake the yard, I sweat. I seem to even have trouble sleeping on my side at night because of trouble getting enough air into my lungs. Weird, I know. I rated it an 8 because I do not feel sick after taking it and it does seem to work. The last but not least worry is heavy hair loss. I have thin and fine hair anyway, but it comes out like crazy”

8 / 10
Was this helpful?YesNo
Motown · Taken for less than 1 month February 16, 2019

“I was diagnosed with RA after a knee arthroscopy seemed to set it off in 2017. I had pains in both knees, left wrist, hips, groin area & jaw so my Rheumatologist prescribed Hydroxychloroquine. After only 10 days I developed a terrible lumpy rash on my legs which was hot & itchy. It spread quickly to my abdomen, bottom arms & back, then I got a sore throat & swollen top lip! I stopped the tablets on the 12th day but the rash still spread. My GP put me on Steroids & Antihistamines. Hopefully this will stop the rash. It's amazing they tell you it can take 3months for hydroxychloroquine to be effective ( but only 10days to cause side effects!)”

1 / 10
Was this helpful?YesNo
Anonymous June 11, 2010

“I began taking Plaquenil 6 weeks ago and I am pleased with it. I'm now seeing the benefits and my Rheumatologist says that I should continue to get even better over the next 3 months. Honestly I'm okay with where I'm already at. The biggest surprise is that I'm receiving benefits that I didn't get from 20mg/day of Prednisone! The hardest part was when I first began Plaquenil. You initially experience side effects without any benefit but you just have to hang in there. The side effects start to improve significantly after 2 weeks. My side effects were nausea, loose stools, vomiting and temporary changes in vision (full eye exam confirmed that everything is fine.) I would highly recommend this medicine!”

10 / 10
Was this helpful?YesNo
NC Gal · Taken for 6 months to 1 year July 3, 2012

“My Rheumatologist prescribed this for my rheumatoid arthritis and it is like a miracle for me. For the first time in several years I actually feel like getting out and doing things without restrictions. The joint pain has lessened and my rash subsided! I do plan on making an appointment for an eye Dr. due to some irritations I recently have been experiencing. All in all, I would highly recommend Plaquenil and hope you can see and feel the difference.”

9 / 10
Was this helpful?YesNo
Sadiemybeagle March 2, 2016

“I'm a 57 year old female that has just been diagnosed with RA about 6 weeks ago. My GP gave me Arthrotech to get me through until I could see the rheumatologist The Arthrotech made me sick, for every 4 pills I took, I threw one up. Went to specialist yesterday and he gave me Plaquenil - I've only taken it for 2 days so far (400 mg) daily but I'm feeling worse ( although the weather has changed - snow storm) I can't believe how painful this disease is. Does it get any better? Will I have a pain free normal life one day soon? I don't go back to the specialist until May but I can't imagine being in this much pain until at least May. I'm feeling so sorry for myself and cry because I'm tired cry because I'm sore. When will it start working?”

3 / 10
Was this helpful?YesNo
mfried2001 July 6, 2010

“Plaquenil has changed my life! I was diagnosed with rheumatoid arthritis three months ago. My rheumotologist started me on this 200mg twice a day and after about a week I noticed a dramatic effect in my hands and feet. I used to wake up in the morning with swollen hands and feet and it took about a half an hour for the swelling/pain to subside. No longer is this true! I am 37 years old and finally have enough energy to keep up with my 4 children and busy husband. I sleep better, feel more focused in the daytime, and do not get tired from doing small tasks anymore. I am hoping to reduce my dosage and see if I can still get the same results.”

10 / 10
Was this helpful?YesNo

This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

Learn more about Rheumatoid Arthritis

IBM Watson Micromedex

Symptom checker

Symptoms and treatments

Drugs.com Health Center

Mayo Clinic Reference