Skip to Content
Print

Plaquenil Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Plaquenil Remove Plaquenil from your drug comparison Methotrexate Remove Methotrexate from your drug comparison Enbrel Remove Enbrel from your drug comparison
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Plaquenil hydroxychloroquine Remove Plaquenil from your drug comparison Methotrexate Remove Methotrexate from your drug comparison Enbrel etanercept Remove Enbrel from your drug comparison

Prescribed for Lyme Disease - Arthritis, Dermatomyositis, Malaria, Malaria Prevention, Rheumatoid Arthritis, Systemic Lupus Erythematosus. May also be prescribed off label for Sjogren's Syndrome,... View more

Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more

Enbrel is a subcutaneous injection that is usually self-administered once or twice a week for inflammatory conditions such as rheumatoid arthritis, psoriasis, psoriatic arthritis, or ankylosing... View more

Prescription only

Prescription only

Prescription only

Ratings & Reviews

View all 144 reviews

View all 249 reviews

View all 245 reviews

Drug Class

Side Effects

See the full Plaquenil side effects document.

Commonly reported side effects include: increased liver enzymes.

See the full methotrexate side effects document.

Common side effects include: infection, injection site reaction.

See the full Enbrel side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 100 tablet
Dosage 200 mg
Per Unit* $11.62
Cost* $1,161.57

View all Plaquenil prices and generic prices

Quantity 20 tablet
Dosage 2.5 mg
Per Unit* $2.69
Cost* $53.89

View all methotrexate prices

Quantity 4 mL
Dosage 50 mg/mL
Per Unit* $1,560.07 - $1,591.86
Cost* $6,240.26 - $6,367.42

View all Enbrel prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Generic Availability

Yes

Yes (this medicine)

No

Dosage Form(s) Available
  • Oral tablet
  • Injectable powder for injection
  • Injectable solution
  • Oral tablet
  • Subcutaneous kit
  • Subcutaneous solution

Brand Names

N/A

 Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep Other etanercept brands include: Erelzi, Eticovo

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

N/A

12 hours

300 hours

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
N
Category N Not classified

See the full Pregnancy Warnings document.
X
Category X Not for use in pregnancy

See the full Pregnancy Warnings document.
B
Category B No proven risk in humans

See the full Pregnancy Warnings document.

Drug Interactions

A total of 433 drugs are known to interact with Plaquenil:

  • 180 major drug interactions (540 brand and generic names)
  • 249 moderate drug interactions (965 brand and generic names)
  • 4 minor drug interactions (20 brand and generic names)

A total of 601 drugs are known to interact with methotrexate:

  • 123 major drug interactions (598 brand and generic names)
  • 462 moderate drug interactions (2454 brand and generic names)
  • 16 minor drug interactions (49 brand and generic names)

A total of 397 drugs are known to interact with Enbrel:

  • 236 major drug interactions (703 brand and generic names)
  • 154 moderate drug interactions (600 brand and generic names)
  • 7 minor drug interactions (33 brand and generic names)

Alcohol/Food/Lifestyle Interactions
  • You may want to limit your consumption of grapefruit or grapefruit juice during treatment with... View more
  • Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are... View more
  • Methotrexate may cause liver problems, and using it with other medications that can also affect the... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

April 18, 1955

December 07, 1953

November 02, 1998

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Compare Drugs

To view a detailed report comparing 3 or more drugs, please sign in or register.