Plaquenil Alternatives Compared
| Plaquenil | Methotrexate | Enbrel |
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| Plaquenil (hydroxychloroquine) | Methotrexate | Enbrel (etanercept) |
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Prescription only
Prescribed for Lyme Disease - Arthritis, Rheumatoid Arthritis, Dermatomyositis, Systemic Lupus Erythematosus, Malaria, Malaria Prevention. Plaquenil may also be used for purposes not listed in this... View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Prescription only
Enbrel is a subcutaneous injection that is usually self-administered once or twice a week for inflammatory conditions such as rheumatoid arthritis, psoriasis, psoriatic arthritis, or ankylosing... View more |
Related suggestions Rheumatoid Arthritis
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| More about Plaquenil (hydroxychloroquine) | More about Methotrexate | More about Enbrel (etanercept) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Plaquenil has an average rating of 6.5 out of 10 from a total of 115 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 25% reported a negative effect. |
Methotrexate has an average rating of 6.6 out of 10 from a total of 266 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 24% reported a negative effect. |
Enbrel has an average rating of 7.8 out of 10 from a total of 264 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 13% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See also: Plaquenil side effects in more detail. |
Commonly reported side effects include:
See also: methotrexate side effects in more detail. |
Common side effects include:
See also: Enbrel side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Plaquenil prices and generic prices |
View all methotrexate prices |
View all Enbrel prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
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N/A |
Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep | Other etanercept brands include: Erelzi, Eticovo | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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N/A |
15 hours |
300 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category N
Not classified
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 441 drugs are known to interact with Plaquenil:
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A total of 627 drugs are known to interact with methotrexate:
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A total of 421 drugs are known to interact with Enbrel:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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April 18, 1955 |
December 07, 1953 |
November 02, 1998 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.