Comparing Methotrexate vs Plaquenil
| Methotrexate | Plaquenil |
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| Methotrexate | Plaquenil (hydroxychloroquine) |
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Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Prescription only
Prescribed for Lyme Disease - Arthritis, Rheumatoid Arthritis, Systemic Lupus Erythematosus, Dermatomyositis, Malaria, Malaria Prevention. Plaquenil may also be used for purposes not listed in this... View more |
Related suggestions Rheumatoid Arthritis
Dermatomyositis
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| More about Methotrexate | More about Plaquenil (hydroxychloroquine) | ||||||||||||||||
| Generic Status | |||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Methotrexate has an average rating of 6.6 out of 10 from a total of 277 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 24% reported a negative effect. |
Plaquenil has an average rating of 6.5 out of 10 from a total of 156 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 25% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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Commonly reported side effects include:
See also: methotrexate side effects in more detail. |
See also: Plaquenil side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all methotrexate prices |
View all Plaquenil prices and generic prices |
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| Dosage Form(s) Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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15 hours |
N/A |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category N
Not classified
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 642 drugs are known to interact with methotrexate:
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A total of 447 drugs are known to interact with Plaquenil:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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December 07, 1953 |
April 18, 1955 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
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N/A |
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| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.