Comparing Malarone vs Plaquenil

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Malarone (atovaquone / proguanil)	Plaquenil (hydroxychloroquine)	Enter another drug to compare

Malarone (atovaquone / proguanil)

Plaquenil (hydroxychloroquine)

Prescription only

Prescribed for Malaria Prevention, Malaria. Malarone may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Rheumatoid Arthritis, Lupus, Lyme Disease - Arthritis, Dermatomyositis, Malaria Prevention, Malaria. Plaquenil may also be used for purposes not listed in this medication guide.

More about Malarone (atovaquone / proguanil)

More about Plaquenil (hydroxychloroquine)

Ratings & Reviews

Malarone has an average rating of 5.5 out of 10 from a total of 45 ratings on Drugs.com. 44% of reviewers reported a positive effect, while 40% reported a negative effect.

Plaquenil has an average rating of 6.4 out of 10 from a total of 158 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 28% reported a negative effect.

View all 45 reviews

View all 158 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Malarone side effects

Nausea (9.5%)
Pain (9.5%)
Rash (8.9%)
Hair loss (7.6%)
Fatigue (7.0%)
Upset stomach (7.0%)
Dizziness (5.1%)

View all Plaquenil side effects

Drug Class

Antimalarial combinations

Generic Availability

Lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	24 tablet
Strength	250 mg-100 mg
Per unit^*	$7.75
Cost^*	$185.93

View all Malarone prices

Quantity	30 tablet
Strength	200 mg
Per unit^*	$0.49
Cost^*	$14.83

View all Plaquenil prices

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Dosage Forms

Oral tablet

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

60.5 hours

N/A

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category N Not classified

See the full pregnancy warnings document.

Drug Interactions

A total of 124 drugs are known to interact with Malarone:

13 major drug interactions (27 brand and generic names)
104 moderate drug interactions (584 brand and generic names)
7 minor drug interactions (21 brand and generic names)

A total of 586 drugs are known to interact with Plaquenil:

224 major drug interactions (717 brand and generic names)
346 moderate drug interactions (1289 brand and generic names)
16 minor drug interactions (50 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Food significantly enhances the absorption of atovaquone. You should take each dose of atovaquone... View more

You may want to limit your consumption of grapefruit or grapefruit juice during treatment with... View more

Disease Interactions

First Approval Date

July 14, 2000

April 18, 1955

WADA Class View classifications

N/A

More Information

Patient Resources

Malarone uses

Plaquenil uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Malarone vs Plaquenil

See also:

Plaquenil

Vibramycin

Ozempic

Cleocin

Monodox

Mepron

Oracea

Coartem

Doryx

Vibra-Tabs

Further information

Comparing Malarone vs Plaquenil

See also:

Further information

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