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Malarone (atovaquone / proguanil) Disease Interactions

There are 2 disease interactions with Malarone (atovaquone / proguanil):


Atovaquone (Includes Malarone) ↔ Gastrointestinal Absorption

Moderate Potential Hazard, High plausibility

Applies to: Anorexia/Feeding Problems, Malabsorption Syndrome, Diarrhea

Oral bioavailability of atovaquone is limited under fasting conditions, but is increased approximately two-fold when administered with food. Patients with gastrointestinal disorders or eating difficulties may be more likely to have impaired absorption and, consequently, subtherapeutic levels of the drug. Alternative parenteral treatment should be considered for patients unable to achieve adequate plasma concentrations of atovaquone with oral administration.


  1. Rolan PE, Mercer AJ, Weatherley BC, Holdich T, Ridout G, Meire H "Investigation of the factors responsible for a food-induced increase in absorption of a novel antiprotozoal drug 566C80." Br J Clin Pharmacol 33 (1992): p534-5
  2. "Product Information. Mepron (atovaquone)." Glaxo Wellcome, Research Triangle Park, NC.

Atovaquone (Includes Malarone) ↔ Liver Disease

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

Atovaquone may cause elevated liver function tests. In clinical trials, elevated serum alkaline phosphatase concentrations (> 2.5 times the upper limit of normal, or ULN) were reported in approximately 8% of patients, and elevations in serum ALT and AST (> 5 times ULN) were reported in 6% and 4% of patients, respectively. Increases in serum bilirubin has occurred rarely. Atovaquone also may undergo limited metabolism by the liver. Therapy with atovaquone should be administered cautiously in patients with severe hepatic impairment. Liver function tests should be performed periodically, and therapy withdrawn if significant elevations develop.


  1. "Product Information. Mepron (atovaquone)." Glaxo Wellcome, Research Triangle Park, NC.

Malarone (atovaquone / proguanil) drug Interactions

There are 116 drug interactions with Malarone (atovaquone / proguanil)

Malarone (atovaquone / proguanil) alcohol/food Interactions

There is 1 alcohol/food interaction with Malarone (atovaquone / proguanil)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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