Meclofenamate Side Effects
Commonly reported side effects of meclofenamate include: behavioral changes, diarrhea, and nausea. Other side effects include: abdominal distention, abdominal pain, dizziness, headache, nausea and vomiting, dyspepsia, and skin rash. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to meclofenamate: oral capsules
Side effects include:
Diarrhea, nausea with or without vomiting, other GI disorders, abdominal pain, flatulence, pyrosis, dizziness, headache, rash.
For Healthcare Professionals
Applies to meclofenamate: compounding powder, oral capsule
Cardiovascular side effects have included edema and palpitations.[Ref]
Dermatologic side effects have included rash, urticaria, and pruritus. Dermatologic side effects reported in less than 1% of test subjects have included erythema multiforme, Stevens-Johnson Syndrome, and exfoliative dermatitis.[Ref]
Gastrointestinal side effects have included diarrhea (10 to 33%), nausea with or without vomiting (11%), other gastrointestinal disorders (10%), and abdominal pain. Less frequently reported gastrointestinal side effects have included pyrosis, flatulence, anorexia, constipation, stomatitis, and peptic ulcer (most patients with peptic ulcer had either a history of ulcer disease or were receiving concomitant anti-inflammatory drugs). Gastrointestinal side effects reported in less than 1% of patients have included bleeding and/or perforation with or without obvious ulcer formation, colitis, cholestatic jaundice, and gastric ileus.[Ref]
General side effects with an unknown causal relationship have included malaise, fatigue, paresthesia, insomnia, depression, blurred vision, taste disturbances, decreased visual acuity, temporary loss of vision, reversible loss of color vision, retinal changes including macular fibrosis, macular and perimacular edema, conjunctivitis, and iritis.[Ref]
Hematologic side effects were reported in less than 1% of test subjects and have included neutropenia, thrombocytopenic purpura, leukopenia, agranulocytosis, hemolytic anemia, eosinophilia, and decrease in hemoglobin and/or hematocrit.[Ref]
Hepatic side effects have included alteration of lever function tests (less than 1%).[Ref]
Nervous system side effects have included headache and dizziness.[Ref]
Other side effects have included tinnitus (3 to 9%). Other side effects occurring in less than 1% of test subjects have included lupus and serum sickness-like symptoms.[Ref]
Renal side effects have included renal failure (less than 1%) and nocturia (less than 1%).[Ref]
1. "Product Information. Meclofenamate Sodium (meclofenamate)." Sandoz Inc, Broomfield, CO.
Not all side effects for meclofenamate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
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