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Meclofenamate Pregnancy and Breastfeeding Warnings

Meclofenamate is also known as: Meclomen

Meclofenamate Pregnancy Warnings

Use should be avoided. US FDA pregnancy category: C Comments: Use during the third trimester may cause premature closure of the fetal ductus arteriosus.

Animal reproductive studies have failed to reveal evidence of developmental abnormalities. Administration of nonsteroidal anti-inflammatory drugs (NSAIDs) during the third trimester of pregnancy may cause significant adverse effects, including premature closure of the fetal ductus. In animal studies, administration of NSAIDs during labor and delivery demonstrated an increased incidence of dystocia, delayed parturition, and decreased pup survival. There are no controlled data in human pregnancy. US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

See references

Meclofenamate Breastfeeding Warnings

A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Excreted into human milk: Unknown Excreted into animal milk: Data not available Comments: The effects in the nursing infant are unknown.

Since no information is available regarding use of this drug during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.

See references

References for pregnancy information

  1. "Product Information. Meclofenamate Sodium (meclofenamate)." Mylan Pharmaceuticals Inc, Morgantown, WV.

References for breastfeeding information

  1. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):
  2. "Product Information. Meclofenamate Sodium (meclofenamate)." Mylan Pharmaceuticals Inc, Morgantown, WV.

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