Medically reviewed by Drugs.com. Last updated on April 17, 2019.
Applies to the following strengths: 70 mg/mL; 140 mg/mL
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Migraine Prophylaxis
70 mg subcutaneously once a month
-Some patients may benefit from 140 mg subcutaneously once a month
Use: For the preventative treatment of migraine.
Renal Dose Adjustments
No adjustment recommended
Liver Dose Adjustments
No adjustment recommended
Elderly: No specific recommendations, however, in general, dose selection should be cautious, generally starting at the low end of the dosing range.
-Serious hypersensitivity to the active substance or any product excipients; anaphylaxis and angioedema have occurred.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
-For subcutaneous use only
-Administer subcutaneously in the abdomen, thigh, or upper arm; do not inject into areas where the skin is tender, bruised, red, or hard
-Patients/caregivers should be trained to properly administer using the single-dose prefilled autoinjector or single-dose prefilled syringe
-Store refrigerated at 2C to 8C (36F to 46F) in the original container to protect from light; do not freeze
-Once removed from refrigerator, keep at room temperature (up to 25C [77F]) in the original carton and use within 7 days; discard unused product kept at room temperature for more than 7 days
-Prior to administration, allow drug to sit at room temperature for at least 30 minutes (protect from direct sunlight); do not warm by using a heat source such as hot water or a microwave
-Do not shake
-The needle shield within the white cap of the prefilled autoinjector and gray needle cap of the prefilled syringe contain dry natural rubber (a derivative of latex); this may cause allergic reactions in individuals sensitive to latex.
-In clinical trials, doses of 70 mg and 140 mg were compared to placebo; drug-treatment with both doses demonstrated statistically significant improvements compared to placebo; additionally, patients receiving 140 mg/month showed some improvement over the 70 mg/month dose, although doses were not titrated up nor directly compared.
-Monitor for severe constipation
-Monitor for hypertension
-Patients should be instructed to read the US FDA-approved Patient Information and Instructions for Use.
-Patients should receive instruction on proper subcutaneous administration technique.
-Patients should be instructed to seek immediate medical attention if they experience any symptoms of a serious or severe hypersensitivity reaction, severe constipation, and/or hypertension or worsening of preexisting hypertension.
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