Applies to the following strength(s): 50 mg ; 100 mg ; 150 mg ; 300 mg
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Depression
150 mg orally per day in divided doses; this may be increased by 50 mg orally per day every 3 to 4 days
Maximum dose: 400 mg orally per day in divided doses (outpatients); 600 mg orally per day in divided doses (inpatients)
150 mg orally once a day; this may be increased by 75 mg orally per day every 3 days (i.e., start 225 mg orally on Day 4 of therapy)
Maximum dose: 375 mg orally per day
-Patients should be monitored for withdrawal symptoms when discontinuing therapy.
-After an adequate response has been reached, dosage may be gradually reduced depending on therapeutic response.
-If drowsiness develops, a major portion of the daily dose may be administered at bedtime or a reduction of dosage may be necessary.
-Immediate release tablets should be taken shortly after a meal or light snack.
-Extended release tablets should be taken orally at the same time every day, in the late evening preferably at bedtime, on an empty stomach.
Use: Treatment of major depressive disorder (MDD) in adults
Renal Dose Adjustments
Renal impairment: Use with caution
Liver Dose Adjustments
Hepatic impairment: Use with caution
Suicidality and Antidepressant Drugs:
-Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders.
-Anyone considering the use of this drug or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24. There was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older.
-Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber.
-This drug is not approved for use in pediatric patients.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
-Tablets can be swallowed whole or administered as a half tablet by breaking the tablet along the score line.
-Tablets should not be chewed or crushed.
-Tolerability may be improved by taking the drug after a meal.
-Psychiatric: Patients should be monitored for worsening and emergence of suicidal thoughts.
-Patients should be cautioned accordingly since this drug may impair the mental and/or physical abilities required for the performance of operating an automobile or machinery.
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- Drug class: phenylpiperazine antidepressants