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Analgesic combinations

Written on May 29, 2018 by C. Fookes, BPharm

Medically reviewed on May 29, 2018 by C. Fookes, BPharm

What are Analgesic combinations?

Analgesic combination products contain at least one analgesic in combination with another medicine or medicines. An analgesic is the name given to a medicine that relieves pain without putting you to sleep or making you lose consciousness. Analgesics may also be known as painkillers or pain relievers.

If an analgesic combination product contains two analgesics, these generally have different ways of working to relieve pain.

Analgesic combination products tend to either have acetaminophen, an NSAID (such as ibuprofen or naproxen), codeine (or another opioid) as one of their ingredients.

What are analgesic combinations used for?

Analgesic combinations may be taken to relieve pain that arises from a wide range of conditions, such as:

It is important to note that not all analgesic combinations are appropriate for all these conditions.

What are the differences between the different analgesic combinations?

Analgesic combinations differ in the ingredients they contain which means there are vast differences in the way they work, their potency, (how strong they are), and in the way they are absorbed, distributed, metabolized and excreted within the body.

Some analgesic combinations contain NSAIDs, whereas others contain opioids (narcotics). Other ingredients may include caffeine, which enhances the pain-relieving effect of an analgesic, and diphenhydramine, which is used for its sleep-inducing properties.

Analgesic combinations that contain opioids should only be used if other analgesics or analgesic combinations have proved ineffective as they are potentially addictive.

Common Analgesic combinations available in the U.S.

Generic name Brand name examples
acetaminophen + aspirin Excedrin Back & Body
acetaminophen + aspirin + caffeine ArthritenExcedrin, Goody's Extra-Strength
acetaminophen + butalbital AllzitalBupap
acetaminophen + butalbital + caffeine Capacet, Esgic, Fioricet
acetaminophen + caffeine Excedrin Quick Tab, Excedrin Tension Headache
acetaminophen +caffeine + isometheptene mucate Prodrin
Acetaminophen + caffeine + magnesium salicylate KneeRelief
Acetaminophen + diphenhydramine Midol PM, Percogesic Extra Strength
acetaminophen + phenyltoloxamine CR Lagesic, Myophen
aspirin + butalbital + caffeine Butalbital compound, Fiorinal
codeine + acetaminophen Tylenol with codeine
codeine + acetaminophen + butalbital + caffeine Fioricet with codeine
codeine + aspirin + butalbital + caffeine Ascomp with codeine, Fiorinal with codeine
dihydrocodeine + acetaminophen + caffeine Panlor-DC, Trezix
hydrocodone + acetaminophen Hycet, Lorcet, Lortab, Maxidone, Norco, Vicodin
hydrocodone + ibuprofen Ibudone, Reprexain, Vicoprofen, Xylon 10
ibuprofen + diphenhydramine Advil PM
naproxen + diphenhydramine Aleve PM, Excedrin PM, Tylenol PM
oxycodone + acetaminophen Endocet, Magnacet, Percocet, Primlev, Roxicet, Tylox, Xartemis XR
tramadol + acetaminophen Ultracet

Are analgesic combinations safe?

Most analgesic combinations are considered safe when taken for short periods of time and exactly as directed on the packaging or by a doctor. Some analgesic combinations, such as those containing acetaminophen or ibuprofen, may be considered safer than others.

Narcotic analgesic combinations have been associated with some serious risks such as respiratory depression (unusually slow and shallow breathing), opioid-use disorder, and potentially fatal overdose. They are potentially addictive and should only be used for certain conditions and under strict monitoring.

What are the side effects of analgesic combinations?

All medicines have side effects but how vulnerable a person is to them depends on several different factors such as age, genetics, kidney function and gender (see Managing Common Drug Side Effects)

Narcotic analgesic combinations have many side effects, although people with cancer or a terminal illness taking narcotic analgesic combinations for long periods of time may become tolerant to some of these side effects.

Drowsiness, sleepiness, or dizziness are common with most narcotic analgesic combinations. These side effects may affect driving or a person's ability to operate machinery and perform other hazardous tasks. Alcohol may potentiate these effects

Combination analgesics containing NSAIDs may also cause side effects, especially when used at higher than recommended dosages for long periods of time. Gastrointestinal side effects that may occur include bloating, diarrhea, constipation, irritation of the lining of the stomach, nausea or vomiting. Combination products containing NSAIDs may also affect kidney function and reduce how quickly blood flows through the kidneys. They may cause retention of sodium and water which can lead to edema and high potassium levels. Occasionally, they may cause more serious damage to the kidneys. NSAIDs have also been associated with a higher risk of cardiovascular disease.

Combination products that contain agents that enhance sleep such as diphenhydramine may also cause drowsiness and affect a person’s ability to drive, operate machinery, or perform other hazardous tasks.

Please refer to each combination product for a full list of side effects.

List of Analgesic combinations:

Filter by:
Drug NameView by: Brand | Generic Reviews Avg. Ratings
Goody's Body Pain
generic name: acetaminophen/aspirin
0 reviews
   
10
KneeRelief
generic name: acetaminophen/caffeine/magnesium salicylate
2 reviews
   
10
Micrainin
generic name: aspirin/meprobamate
1 review
   
10
Phrenilin
generic name: acetaminophen/butalbital
1 review
   
10
Vanquish
generic name: acetaminophen/aspirin/caffeine
1 review
   
10
BC Fast Pain Relief
generic name: aspirin/caffeine/salicylamide
1 review
   
9.8
Esgic (Pro)
generic name: acetaminophen/butalbital/caffeine
9 reviews
   
9.6
MigraTen
generic name: acetaminophen/caffeine/isometheptene mucate
3 reviews
   
9.3
Esgic-Plus (Pro)
generic name: acetaminophen/butalbital/caffeine
12 reviews
   
9.2
Percogesic
generic name: acetaminophen/phenyltoloxamine
17 reviews
   
9.2
Bupap (Pro)
generic name: acetaminophen/butalbital
5 reviews
   
9.0
Excedrin Quick Tab
generic name: acetaminophen/caffeine
2 reviews
   
9.0
Midol Complete
generic name: acetaminophen/caffeine/pyrilamine
0 reviews
   
9.0
Painaid
generic name: acetaminophen/aspirin/caffeine/salicylamide
0 reviews
   
9.0
Premsyn PMS
generic name: acetaminophen/pamabrom/pyrilamine
1 review
   
9.0
Zebutal (Pro)
generic name: acetaminophen/butalbital/caffeine
0 reviews
   
9.0
Butalbital Compound
generic name: aspirin/butalbital/caffeine
16 reviews
   
8.7
Fioricet (Pro)
generic name: acetaminophen/butalbital/caffeine
129 reviews
   
8.7
Fiorinal (Pro)
generic name: aspirin/butalbital/caffeine
64 reviews
   
8.6
Dolgic Plus (Pro)
generic name: acetaminophen/butalbital/caffeine
7 reviews
   
8.5
Midol PM
generic name: acetaminophen/diphenhydramine
2 reviews
   
8.5
Excedrin Tension Headache
generic name: acetaminophen/caffeine
3 reviews
   
8.4
Prodrin
generic name: acetaminophen/caffeine/isometheptene mucate
5 reviews
   
8.4
Goody's Extra-Strength Headache Powders
generic name: acetaminophen/aspirin/caffeine
9 reviews
   
8.3
Goody's Headache Powders
generic name: acetaminophen/aspirin/caffeine
2 reviews
   
8.0
Lagesic
generic name: acetaminophen/phenyltoloxamine
1 review
   
8.0
Myophen
generic name: acetaminophen/phenyltoloxamine
1 review
   
8.0
Excedrin Back & Body
generic name: acetaminophen/aspirin
2 reviews
   
7.8
Excedrin
generic name: acetaminophen/aspirin/caffeine
21 reviews
   
7.6
Aleve PM
generic name: diphenhydramine/naproxen
26 reviews
   
6.8
Tylenol PM
generic name: acetaminophen/diphenhydramine
18 reviews
   
6.4
Excedrin PM
generic name: acetaminophen/diphenhydramine
6 reviews
   
6.1
Goody's Extra Strength
generic name: acetaminophen/aspirin/caffeine
1 review
   
6.0
Headache Relief PM
generic name: acetaminophen/diphenhydramine
1 review
   
6.0
Dolgic LQ
generic name: acetaminophen/butalbital/caffeine
0 reviews
   
5.5
Advil PM (Pro)
generic name: diphenhydramine/ibuprofen
1 review
   
5.0
Orbivan (Pro)
generic name: acetaminophen/butalbital/caffeine
0 reviews
   
5.0
Aceta-Gesic
generic name: acetaminophen/diphenhydramine
0 reviews
   
4.0
Dologesic
generic name: acetaminophen/phenyltoloxamine
0 reviews
   
3.0
Levacet
generic name: acetaminophen/aspirin/caffeine/salicylamide
1 review
   
3.0
Unisom PM Pain
generic name: acetaminophen/diphenhydramine
0 reviews
   
2.0
Acuflex
generic name: acetaminophen/phenyltoloxamine
0 reviews
   
1.0
Alagesic LQ (Pro)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Ali-Flex
generic name: acetaminophen/phenyltoloxamine
0 reviewsAdd rating
Alka-Seltzer Wake-Up Call!
generic name: aspirin/caffeine
0 reviewsAdd rating
Allzital
generic name: acetaminophen/butalbital
0 reviewsAdd rating
Anacin Advanced Headache Formula
generic name: acetaminophen/aspirin/caffeine
0 reviewsAdd rating
Anolor 300
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Arthriten
generic name: acetaminophen/aspirin/caffeine
0 reviewsAdd rating
Backaid Inflammatory Pain Formula
generic name: acetaminophen/aspirin/caffeine
0 reviewsAdd rating
Bayer Extra Strength Back & Body
generic name: aspirin/caffeine
0 reviewsAdd rating
Bayer PM
generic name: aspirin/diphenhydramine
0 reviewsAdd rating
BC Arthritis
generic name: aspirin/caffeine
0 reviewsAdd rating
Be-Flex Plus
generic name: acetaminophen/phenyltoloxamine/salicylamide
0 reviewsAdd rating
Capacet (Pro)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Cope
generic name: aspirin/caffeine
0 reviewsAdd rating
Coricidin Night Time Cold Relief
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Cramp Tabs
generic name: acetaminophen/pamabrom
0 reviewsAdd rating
Doans PM
generic name: diphenhydramine/magnesium salicylate
0 reviewsAdd rating
Dologesic DF
generic name: acetaminophen/phenyltoloxamine
0 reviewsAdd rating
Duraxin
generic name: acetaminophen/phenyltoloxamine/salicylamide
0 reviewsAdd rating
Ed-Flex
generic name: acetaminophen/phenyltoloxamine/salicylamide
0 reviewsAdd rating
Equagesic (Pro)
generic name: aspirin/meprobamate
0 reviewsAdd rating
Ezol
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Flextra
generic name: acetaminophen/caffeine/phenyltoloxamine
0 reviewsAdd rating
Flextra-650
generic name: acetaminophen/phenyltoloxamine
0 reviewsAdd rating
Genace
generic name: acetaminophen/aspirin/caffeine
0 reviewsAdd rating
Geone
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
HistaFlex
generic name: acetaminophen/pyrilamine
0 reviewsAdd rating
Ibuprofen PM (Pro)
generic name: diphenhydramine/ibuprofen
0 reviewsAdd rating
Legatrin PM
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Mapap PM
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Margesic (Pro)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Marten-Tab (Pro)
generic name: acetaminophen/butalbital
0 reviewsAdd rating
Medigesic
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Menstrual Pain Relief
generic name: acetaminophen/pamabrom/pyrilamine
0 reviewsAdd rating
Menstrual PMS
generic name: acetaminophen/pamabrom/pyrilamine
0 reviewsAdd rating
Midol
generic name: acetaminophen/pamabrom
0 reviewsAdd rating
Midol PMS Maximum Strength
generic name: acetaminophen/pamabrom/pyrilamine
0 reviewsAdd rating
Midol Teen
generic name: acetaminophen/pamabrom
0 reviewsAdd rating
Motrin PM (Pro)
generic name: diphenhydramine/ibuprofen
0 reviewsAdd rating
Night Time Pain
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Nonbac
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Orbivan CF
generic name: acetaminophen/butalbital
0 reviewsAdd rating
P-A-C
generic name: aspirin/caffeine
0 reviewsAdd rating
P-A-C Analgesic
generic name: aspirin/caffeine
0 reviewsAdd rating
Pacaps
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Pain Relief PM Extra Strength
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Pamprin Cramp Menstrual Pain Relief
generic name: acetaminophen/magnesium salicylate/pamabrom
0 reviewsAdd rating
Pamprin Maximum Pain
generic name: acetaminophen/pamabrom/pyrilamine
0 reviewsAdd rating
Pamprin Max Menstrual Pain Relief
generic name: acetaminophen/aspirin/caffeine
0 reviewsAdd rating
Pamprin Multi-Symptom Menstrual Relief
generic name: acetaminophen/pamabrom/pyrilamine
1 reviewAdd rating
Percogesic Extra Strength
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Relagesic
generic name: acetaminophen/phenyltoloxamine
0 reviewsAdd rating
Repan
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
RhinoFlex 650
generic name: acetaminophen/phenyltoloxamine
0 reviewsAdd rating
Stanback
generic name: aspirin/caffeine
0 reviewsAdd rating
Stanback Fast Pain Relief
generic name: aspirin/caffeine/salicylamide
0 reviewsAdd rating
Tencon
generic name: acetaminophen/butalbital
0 reviewsAdd rating
Tylenol Severe Allergy
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Tylenol Sore Throat Nighttime
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Tylenol Women's Menstrual Relief
generic name: acetaminophen/pamabrom
0 reviewsAdd rating
Uricalm Intensive
generic name: acetaminophen/aspirin/caffeine
0 reviewsAdd rating
Vanatol LQ (Pro)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Vanatol S
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Zflex
generic name: acetaminophen/phenyltoloxamine
0 reviewsAdd rating
Zgesic
generic name: acetaminophen/phenyltoloxamine
0 reviewsAdd rating

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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