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Analgesic combinations

Written on May 29, 2018 by C. Fookes, BPharm

Medically reviewed on May 29, 2018 by C. Fookes, BPharm

What are Analgesic combinations?

Analgesic combination products contain at least one analgesic in combination with another medicine or medicines. An analgesic is the name given to a medicine that relieves pain without putting you to sleep or making you lose consciousness. Analgesics may also be known as painkillers or pain relievers.

If an analgesic combination product contains two analgesics, these generally have different ways of working to relieve pain.

Analgesic combination products tend to either have acetaminophen, an NSAID (such as ibuprofen or naproxen), codeine (or another opioid) as one of their ingredients.

What are analgesic combinations used for?

Analgesic combinations may be taken to relieve pain that arises from a wide range of conditions, such as:

It is important to note that not all analgesic combinations are appropriate for all these conditions.

What are the differences between the different analgesic combinations?

Analgesic combinations differ in the ingredients they contain which means there are vast differences in the way they work, their potency, (how strong they are), and in the way they are absorbed, distributed, metabolized and excreted within the body.

Some analgesic combinations contain NSAIDs, whereas others contain opioids (narcotics). Other ingredients may include caffeine, which enhances the pain-relieving effect of an analgesic, and diphenhydramine, which is used for its sleep-inducing properties.

Analgesic combinations that contain opioids should only be used if other analgesics or analgesic combinations have proved ineffective as they are potentially addictive.

Common Analgesic combinations available in the U.S.

Generic name Brand name examples
acetaminophen + aspirin Excedrin Back & Body
acetaminophen + aspirin + caffeine ArthritenExcedrin, Goody's Extra-Strength
acetaminophen + butalbital AllzitalBupap
acetaminophen + butalbital + caffeine Capacet, Esgic, Fioricet
acetaminophen + caffeine Excedrin Quick Tab, Excedrin Tension Headache
acetaminophen +caffeine + isometheptene mucate Prodrin
Acetaminophen + caffeine + magnesium salicylate KneeRelief
Acetaminophen + diphenhydramine Midol PM, Percogesic Extra Strength
acetaminophen + phenyltoloxamine CR Lagesic, Myophen
aspirin + butalbital + caffeine Butalbital compound, Fiorinal
codeine + acetaminophen Tylenol with codeine
codeine + acetaminophen + butalbital + caffeine Fioricet with codeine
codeine + aspirin + butalbital + caffeine Ascomp with codeine, Fiorinal with codeine
dihydrocodeine + acetaminophen + caffeine Panlor-DC, Trezix
hydrocodone + acetaminophen Hycet, Lorcet, Lortab, Maxidone, Norco, Vicodin
hydrocodone + ibuprofen Ibudone, Reprexain, Vicoprofen, Xylon 10
ibuprofen + diphenhydramine Advil PM
naproxen + diphenhydramine Aleve PM, Excedrin PM, Tylenol PM
oxycodone + acetaminophen Endocet, Magnacet, Percocet, Primlev, Roxicet, Tylox, Xartemis XR
tramadol + acetaminophen Ultracet

Are analgesic combinations safe?

Most analgesic combinations are considered safe when taken for short periods of time and exactly as directed on the packaging or by a doctor. Some analgesic combinations, such as those containing acetaminophen or ibuprofen, may be considered safer than others.

Narcotic analgesic combinations have been associated with some serious risks such as respiratory depression (unusually slow and shallow breathing), opioid-use disorder, and potentially fatal overdose. They are potentially addictive and should only be used for certain conditions and under strict monitoring.

What are the side effects of analgesic combinations?

All medicines have side effects but how vulnerable a person is to them depends on several different factors such as age, genetics, kidney function and gender (see Managing Common Drug Side Effects)

Narcotic analgesic combinations have many side effects, although people with cancer or a terminal illness taking narcotic analgesic combinations for long periods of time may become tolerant to some of these side effects.

Drowsiness, sleepiness, or dizziness are common with most narcotic analgesic combinations. These side effects may affect driving or a person's ability to operate machinery and perform other hazardous tasks. Alcohol may potentiate these effects

Combination analgesics containing NSAIDs may also cause side effects, especially when used at higher than recommended dosages for long periods of time. Gastrointestinal side effects that may occur include bloating, diarrhea, constipation, irritation of the lining of the stomach, nausea or vomiting. Combination products containing NSAIDs may also affect kidney function and reduce how quickly blood flows through the kidneys. They may cause retention of sodium and water which can lead to edema and high potassium levels. Occasionally, they may cause more serious damage to the kidneys. NSAIDs have also been associated with a higher risk of cardiovascular disease.

Combination products that contain agents that enhance sleep such as diphenhydramine may also cause drowsiness and affect a person’s ability to drive, operate machinery, or perform other hazardous tasks.

Please refer to each combination product for a full list of side effects.

List of Analgesic combinations:

Filter by:
Drug NameView by: Brand | Generic Reviews Avg. Ratings
Goody's Body Pain (More...)
generic name: acetaminophen/aspirin
0 reviews
   
10
KneeRelief (More...)
generic name: acetaminophen/caffeine/magnesium salicylate
2 reviews
   
10
Micrainin (More...)
generic name: aspirin/meprobamate
1 review
   
10
Phrenilin (More...)
generic name: acetaminophen/butalbital
1 review
   
10
Vanquish (More...)
generic name: acetaminophen/aspirin/caffeine
1 review
   
10
BC Fast Pain Relief (More...)
generic name: aspirin/caffeine/salicylamide
1 review
   
9.8
Esgic (Pro, More...)
generic name: acetaminophen/butalbital/caffeine
9 reviews
   
9.6
MigraTen (More...)
generic name: acetaminophen/caffeine/isometheptene mucate
3 reviews
   
9.3
Esgic-Plus (Pro, More...)
generic name: acetaminophen/butalbital/caffeine
12 reviews
   
9.2
Percogesic (More...)
generic name: acetaminophen/phenyltoloxamine
17 reviews
   
9.2
Bupap (Pro, More...)
generic name: acetaminophen/butalbital
5 reviews
   
9.0
Excedrin Quick Tab (More...)
generic name: acetaminophen/caffeine
2 reviews
   
9.0
Midol Complete (More...)
generic name: acetaminophen/caffeine/pyrilamine
0 reviews
   
9.0
Painaid (More...)
generic name: acetaminophen/aspirin/caffeine/salicylamide
0 reviews
   
9.0
Premsyn PMS (More...)
generic name: acetaminophen/pamabrom/pyrilamine
1 review
   
9.0
Zebutal (Pro, More...)
generic name: acetaminophen/butalbital/caffeine
0 reviews
   
9.0
Butalbital Compound (More...)
generic name: aspirin/butalbital/caffeine
16 reviews
   
8.7
Fioricet (Pro, More...)
generic name: acetaminophen/butalbital/caffeine
128 reviews
   
8.6
Fiorinal (Pro, More...)
generic name: aspirin/butalbital/caffeine
64 reviews
   
8.6
Dolgic Plus (Pro, More...)
generic name: acetaminophen/butalbital/caffeine
7 reviews
   
8.5
Midol PM (More...)
generic name: acetaminophen/diphenhydramine
2 reviews
   
8.5
Excedrin Tension Headache (More...)
generic name: acetaminophen/caffeine
3 reviews
   
8.4
Prodrin (More...)
generic name: acetaminophen/caffeine/isometheptene mucate
5 reviews
   
8.4
Goody's Extra-Strength Headache Powders (More...)
generic name: acetaminophen/aspirin/caffeine
8 reviews
   
8.2
Goody's Headache Powders (More...)
generic name: acetaminophen/aspirin/caffeine
2 reviews
   
8.0
Lagesic (More...)
generic name: acetaminophen/phenyltoloxamine
1 review
   
8.0
Myophen (More...)
generic name: acetaminophen/phenyltoloxamine
1 review
   
8.0
Excedrin Back & Body (More...)
generic name: acetaminophen/aspirin
2 reviews
   
7.8
Excedrin (More...)
generic name: acetaminophen/aspirin/caffeine
20 reviews
   
7.5
Aleve PM (More...)
generic name: diphenhydramine/naproxen
25 reviews
   
6.8
Tylenol PM (More...)
generic name: acetaminophen/diphenhydramine
18 reviews
   
6.4
Excedrin PM (More...)
generic name: acetaminophen/diphenhydramine
6 reviews
   
6.1
Goody's Extra Strength (More...)
generic name: acetaminophen/aspirin/caffeine
1 review
   
6.0
Headache Relief PM (More...)
generic name: acetaminophen/diphenhydramine
1 review
   
6.0
Dolgic LQ (More...)
generic name: acetaminophen/butalbital/caffeine
0 reviews
   
5.5
Advil PM (Pro, More...)
generic name: diphenhydramine/ibuprofen
1 review
   
5.0
Orbivan (Pro, More...)
generic name: acetaminophen/butalbital/caffeine
0 reviews
   
5.0
Aceta-Gesic (More...)
generic name: acetaminophen/diphenhydramine
0 reviews
   
4.0
Dologesic (More...)
generic name: acetaminophen/phenyltoloxamine
0 reviews
   
3.0
Levacet (More...)
generic name: acetaminophen/aspirin/caffeine/salicylamide
1 review
   
3.0
Unisom PM Pain (More...)
generic name: acetaminophen/diphenhydramine
0 reviews
   
2.0
Acuflex (More...)
generic name: acetaminophen/phenyltoloxamine
0 reviews
   
1.0
Alagesic LQ (Pro, More...)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Ali-Flex (More...)
generic name: acetaminophen/phenyltoloxamine
0 reviewsAdd rating
Alka-Seltzer Wake-Up Call! (More...)
generic name: aspirin/caffeine
0 reviewsAdd rating
Allzital (More...)
generic name: acetaminophen/butalbital
0 reviewsAdd rating
Anacin Advanced Headache Formula (More...)
generic name: acetaminophen/aspirin/caffeine
0 reviewsAdd rating
Anolor 300 (More...)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Arthriten (More...)
generic name: acetaminophen/aspirin/caffeine
0 reviewsAdd rating
Backaid Inflammatory Pain Formula (More...)
generic name: acetaminophen/aspirin/caffeine
0 reviewsAdd rating
Bayer Extra Strength Back & Body (More...)
generic name: aspirin/caffeine
0 reviewsAdd rating
Bayer PM (More...)
generic name: aspirin/diphenhydramine
0 reviewsAdd rating
BC Arthritis (More...)
generic name: aspirin/caffeine
0 reviewsAdd rating
Be-Flex Plus (More...)
generic name: acetaminophen/phenyltoloxamine/salicylamide
0 reviewsAdd rating
Capacet (Pro, More...)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Cope (More...)
generic name: aspirin/caffeine
0 reviewsAdd rating
Coricidin Night Time Cold Relief (More...)
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Cramp Tabs (More...)
generic name: acetaminophen/pamabrom
0 reviewsAdd rating
Doans PM (More...)
generic name: diphenhydramine/magnesium salicylate
0 reviewsAdd rating
Dologesic DF (More...)
generic name: acetaminophen/phenyltoloxamine
0 reviewsAdd rating
Duraxin (More...)
generic name: acetaminophen/phenyltoloxamine/salicylamide
0 reviewsAdd rating
Ed-Flex (More...)
generic name: acetaminophen/phenyltoloxamine/salicylamide
0 reviewsAdd rating
Equagesic (Pro, More...)
generic name: aspirin/meprobamate
0 reviewsAdd rating
Ezol (More...)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Flextra (More...)
generic name: acetaminophen/caffeine/phenyltoloxamine
0 reviewsAdd rating
Flextra-650 (More...)
generic name: acetaminophen/phenyltoloxamine
0 reviewsAdd rating
Genace (More...)
generic name: acetaminophen/aspirin/caffeine
0 reviewsAdd rating
Geone (More...)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
HistaFlex (More...)
generic name: acetaminophen/pyrilamine
0 reviewsAdd rating
Ibuprofen PM (Pro, More...)
generic name: diphenhydramine/ibuprofen
0 reviewsAdd rating
Legatrin PM (More...)
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Mapap PM (More...)
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Margesic (Pro, More...)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Marten-Tab (Pro, More...)
generic name: acetaminophen/butalbital
0 reviewsAdd rating
Medigesic (More...)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Menstrual Pain Relief (More...)
generic name: acetaminophen/pamabrom/pyrilamine
0 reviewsAdd rating
Menstrual PMS (More...)
generic name: acetaminophen/pamabrom/pyrilamine
0 reviewsAdd rating
Midol (More...)
generic name: acetaminophen/pamabrom
0 reviewsAdd rating
Midol PMS Maximum Strength (More...)
generic name: acetaminophen/pamabrom/pyrilamine
0 reviewsAdd rating
Midol Teen (More...)
generic name: acetaminophen/pamabrom
0 reviewsAdd rating
Motrin PM (Pro, More...)
generic name: diphenhydramine/ibuprofen
0 reviewsAdd rating
Night Time Pain (More...)
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Nonbac (More...)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Orbivan CF (More...)
generic name: acetaminophen/butalbital
0 reviewsAdd rating
P-A-C (More...)
generic name: aspirin/caffeine
0 reviewsAdd rating
P-A-C Analgesic (More...)
generic name: aspirin/caffeine
0 reviewsAdd rating
Pacaps (More...)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Pain Relief PM Extra Strength (More...)
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Pamprin Cramp Menstrual Pain Relief (More...)
generic name: acetaminophen/magnesium salicylate/pamabrom
0 reviewsAdd rating
Pamprin Maximum Pain (More...)
generic name: acetaminophen/pamabrom/pyrilamine
0 reviewsAdd rating
Pamprin Max Menstrual Pain Relief (More...)
generic name: acetaminophen/aspirin/caffeine
0 reviewsAdd rating
Pamprin Multi-Symptom Menstrual Relief (More...)
generic name: acetaminophen/pamabrom/pyrilamine
1 reviewAdd rating
Percogesic Extra Strength (More...)
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Relagesic (More...)
generic name: acetaminophen/phenyltoloxamine
0 reviewsAdd rating
Repan (More...)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
RhinoFlex 650 (More...)
generic name: acetaminophen/phenyltoloxamine
0 reviewsAdd rating
Stanback (More...)
generic name: aspirin/caffeine
0 reviewsAdd rating
Stanback Fast Pain Relief (More...)
generic name: aspirin/caffeine/salicylamide
0 reviewsAdd rating
Tencon (More...)
generic name: acetaminophen/butalbital
0 reviewsAdd rating
Tylenol Severe Allergy (More...)
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Tylenol Sore Throat Nighttime (More...)
generic name: acetaminophen/diphenhydramine
0 reviewsAdd rating
Tylenol Women's Menstrual Relief (More...)
generic name: acetaminophen/pamabrom
0 reviewsAdd rating
Uricalm Intensive (More...)
generic name: acetaminophen/aspirin/caffeine
0 reviewsAdd rating
Vanatol LQ (Pro, More...)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Vanatol S (More...)
generic name: acetaminophen/butalbital/caffeine
0 reviewsAdd rating
Zflex (More...)
generic name: acetaminophen/phenyltoloxamine
0 reviewsAdd rating
Zgesic (More...)
generic name: acetaminophen/phenyltoloxamine
0 reviewsAdd rating
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