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Medications for Premenstrual Syndrome

Other names: PMS; PMT; Premenstrual Tension

Premenstrual syndrome (PMS) refers to a wide range of physical or emotional symptoms that typically occur about 5 to 11 days before a woman starts her monthly menstrual cycle. The symptoms usually stop when menstruation begins, or shortly thereafter.

Drugs used to treat Premenstrual Syndrome

The following list of medications are in some way related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Midol 5.0 3 reviews for Midol to treat Premenstrual Syndrome
OTC N N X
Generic name:
acetaminophen / pamabrom systemic
Drug class:
analgesic combinations
For consumers:
interactions, side effects
Premsyn PMS 9.0 1 review for Premsyn PMS to treat Premenstrual Syndrome
OTC N N X
Generic name:
acetaminophen / pamabrom / pyrilamine systemic
Drug class:
analgesic combinations
For consumers:
interactions, side effects
ethinyl estradiol / levonorgestrel Off-label 4.5 16 reviews for ethinyl estradiol / levonorgestrel to treat Premenstrual Syndrome
Rx X N X
Generic name:
ethinyl estradiol / levonorgestrel systemic
Brand names:
Falmina, LoSeasonique, Chateal, CamreseLo, Myzilra, Amethia Lo, Kurvelo
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
acetaminophen / pamabrom / pyrilamine 9.5 2 reviews for acetaminophen / pamabrom / pyrilamine to treat Premenstrual Syndrome
OTC N N X
Generic name:
acetaminophen / pamabrom / pyrilamine systemic
Brand names:
Premsyn PMS, Pamprin Maximum Pain, Menstrual PMS, Menstrual Pain Relief
Drug class:
analgesic combinations
For consumers:
interactions, side effects
Falmina Off-label 9.0 1 review for Falmina to treat Premenstrual Syndrome
Rx X N X
Generic name:
ethinyl estradiol / levonorgestrel systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
pamabrom 8.0 1 review for pamabrom to treat Premenstrual Syndrome
OTC N N
Generic name:
pamabrom systemic
Brand names:
Diurex Water Capsules, Aqua-Ban, Diurex Aquagels
Drug class:
miscellaneous diuretics
For consumers:
interactions, side effects
Pamprin Maximum Pain Rate Add review
OTC N N X
Generic name:
acetaminophen / pamabrom / pyrilamine systemic
Drug class:
analgesic combinations
For consumers:
interactions, side effects
LoSeasonique Off-label 4.3 3 reviews for LoSeasonique to treat Premenstrual Syndrome
Rx X N X
Generic name:
ethinyl estradiol / levonorgestrel systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
acetaminophen / caffeine / pyrilamine 7.0 2 reviews for acetaminophen / caffeine / pyrilamine to treat Premenstrual Syndrome
OTC N N X
Generic name:
acetaminophen / caffeine / pyrilamine systemic
Drug class:
analgesic combinations
For consumers:
interactions, side effects
Diurex Water Capsules Rate Add review
OTC N N
Generic name:
pamabrom systemic
Drug class:
miscellaneous diuretics
For consumers:
interactions, side effects
Menstrual PMS Rate Add review
OTC N N X
Generic name:
acetaminophen / pamabrom / pyrilamine systemic
Drug class:
analgesic combinations
For consumers:
interactions, side effects
Chateal Off-label 4.0 4 reviews for Chateal to treat Premenstrual Syndrome
Rx X N X
Generic name:
ethinyl estradiol / levonorgestrel systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
CamreseLo Off-label Rate Add review
Rx X N X
Generic name:
ethinyl estradiol / levonorgestrel systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
Menstrual Pain Relief Rate Add review
OTC N N X
Generic name:
acetaminophen / pamabrom / pyrilamine systemic
Drug class:
analgesic combinations
For consumers:
interactions, side effects
Myzilra Off-label Rate Add review
Rx X N X
Generic name:
ethinyl estradiol / levonorgestrel systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
Tylenol Women's Menstrual Relief Rate Add review
OTC N N X
Generic name:
acetaminophen / pamabrom systemic
Drug class:
analgesic combinations
For consumers:
interactions, side effects
Amethia Lo Off-label Rate Add review
Rx X N X
Generic name:
ethinyl estradiol / levonorgestrel systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
Kurvelo Off-label Rate Add review
Rx X N X
Generic name:
ethinyl estradiol / levonorgestrel systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
Aqua-Ban Rate Add review
OTC N N
Generic name:
pamabrom systemic
Drug class:
miscellaneous diuretics
For consumers:
interactions, side effects
Cramp Tabs Rate Add review
OTC N N X
Generic name:
acetaminophen / pamabrom systemic
Drug class:
analgesic combinations
For consumers:
interactions, side effects
Midol Teen Rate Add review
OTC N N X
Generic name:
acetaminophen / pamabrom systemic
Drug class:
analgesic combinations
For consumers:
interactions, side effects
acetaminophen / pamabrom 5.0 3 reviews for acetaminophen / pamabrom to treat Premenstrual Syndrome
OTC N N X
Generic name:
acetaminophen / pamabrom systemic
Brand names:
Midol, Tylenol Women's Menstrual Relief, Cramp Tabs, Midol Teen
Drug class:
analgesic combinations
For consumers:
interactions, side effects
Diurex Aquagels Rate Add review
OTC N N
Generic name:
pamabrom systemic
Drug class:
miscellaneous diuretics
For consumers:
interactions, side effects

Learn more about Premenstrual Syndrome

Care guides

Symptoms and treatments

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.