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Acetaminophen and Hydrocodone

Generic name: acetaminophen and hydrocodone [ a-SEET-a-MIN-oh-fen-and-hye-droe-KOE-done ]
Brand names: Hycet, Lorcet, Norco, Verdrocet, Vicodin, Xodol, Zamicet
Drug class: Narcotic analgesic combinations

Medically reviewed by Melisa Puckey, BPharm. Last updated on Feb 28, 2023.

What is hydrocodone and acetaminophen?

Hydrocodone and acetaminophen is a combination medicine used to relieve moderate to severe pain. Hydrocodone is an opioid pain reliever and cough suppressant that belongs to the group of medicines called narcotic analgesics, that work on the central nervous system. Acetaminophen is a non-opioid analgesic used for pain relief and to reduce fever. Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone.

Hydrocodone and acetaminophen tablets have been marketed under the brand names Norco (discontinued), Vicodin  (discontinued), Lortab (discontinued), Hycet (discontinued), Lorcet (discontinued), Verdrocet (discontinued), Xodol (discontinued), Zamicet (discontinued) and now generic hydrocodone and acetaminophen products are available.

Is hydrocodone with acetaminophen a controlled substance?

Yes, hydrocodone with acetaminophen is a controlled substance. Under the Controlled Substances Act (CSA) hydrocodone (which includes hydrocodone with acetaminophen) is a schedule 2 controlled substance.  This means hydrocodone has a high potential for abuse, it currently has an accepted medical use which may include severe restrictions. Abuse may lead to severe psychological or physical dependence.

What strength is hydrocodone and acetaminophen tablets available as?

Examples of hydrocodone and acetaminophen tablets are:

Sometimes hydrocodone and acetaminophen strengths get abbreviated to hydrocodone acetaminophen 5-325 or hydrocodone acetaminophen 5 325, but is better to use the correct names and strengths (hydrocodone and acetaminophen 5mg/325mg tablets or hydrocodone 5mg and acetaminophen 325mg) to avoid confusion and dosing errors.


MISUSE OF HYDROCODONE AND ACETAMINOPHEN CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in secure a place where others cannot get to it.

Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Acetaminophen and hydrocodone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing. See interactions section below for more information on drug interactions.

Tell your doctor if you drink more than three alcoholic beverages per day or if you have ever had alcoholic liver disease (cirrhosis). You may not be able to take medication that contains acetaminophen.

Stop taking acetaminophen and hydrocodone and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Before taking this medicine

You should not use this medicine if you are allergic to acetaminophen or hydrocodone, or if you have:

To make sure acetaminophen and hydrocodone is safe for you, tell your doctor if you have ever had:


If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.


Do not breastfeed. Acetaminophen and hydrocodone can pass into breast milk and cause drowsiness, breathing problems, or death in a nursing baby.

How should I take hydrocodone and acetaminophen?

Take hydrocodone and acetaminophen exactly as it was prescribed for you. Follow all directions on your prescription label. Never take hydrocodone and acetaminophen in larger amounts, or for longer than prescribed. An overdose can damage your liver or cause death. Tell your doctor if you feel an increased urge to use more of this medicine.

Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine in a place where others cannot get to it. Selling or giving away hydrocodone and acetaminophen is against the law.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

If you need surgery or medical tests, tell the doctor ahead of time that you are using this medicine.

You should not stop using this medicine suddenly. Follow your doctor's instructions about tapering your dose.

Store acetaminophen and hydrocodone at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.


Use: For the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Usual Adult Dose for Pain:

Hydrocodone 2.5 mg-acetaminophen 325 mg per tablet, Hydrocodone 5 mg-acetaminophen 325 mg per tablet

Hydrocodone 7.5 mg-acetaminophen 325 mg, Hydrocodone 10 mg-acetaminophen 325 mg per tablet:

Hydrocodone 7.5 mg-acetaminophen 325 mg per 15 mL oral solution:

Hydrocodone 10 mg-acetaminophen 300 mg per 15 mL oral solution:


For more information on hydocodone/acetminophen doses for adults or children, or dosage adjustments required for medical conditions click on the link below.

What happens if I miss a dose?

Since this medicine is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen and hydrocodone can be fatal.

Acute overdosage with hydrocodone and acetaminophen tablets can cause respiratory depression, sleepiness progressing to near-unconsciousness or coma, floppy muscles, cold and clammy skin, constricted pupils, and, in some cases, pulmonary edema, slow heartbeat, low blood pressure, partial or complete airway obstruction, unusual snoring, and death. If the patient who has overdosed becomes very low in oxygen pupils may become very dilated instead of constricted pupils. 

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

What to avoid

Side effects of hydrocodone and acetaminophen

Common side effects of hydrocodone acetaminophen include:

Serious side effects of hydrocodone acetaminophen include:

Get emergency medical help if you have signs of an allergic reaction to acetaminophen and hydrocodone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Call your doctor at once if you have:

Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydrocodone and acetaminophen?

You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.

Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

This list is not complete. Other drugs may interact with acetaminophen and hydrocodone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. To check for interactions with hydrocodone and acetaminophen, click the link below.

Further information

For more information about hydrocodone and acetaminophen talk to your doctor pharmacist or other heath care professional.

For information on hydrocodone and acetaminophen in Spanish, click here hydrocodone acetaminophen 5-325 españo

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use acetaminophen or hydrocodone only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.