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User Reviews for Acetaminophen / hydrocodone

Also known as: Xodol Zyfrel

Acetaminophen / hydrocodone has an average rating of 6.2 out of 10 from a total of 1,247 ratings on Drugs.com. 53% of reviewers reported a positive experience, while 33% reported a negative experience.

Condition Avg. Rating Reviews Compare
Pain  
6.3
728 reviews 1129 medications
Back Pain  
5.9
410 reviews 180 medications
Rheumatoid Arthritis  Off-label
4.8
77 reviews 363 medications
Cough  
9.6
32 reviews 810 medications
Summary of Acetaminophen / hydrocodone reviews 6.2 1,247 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Acetaminophen / hydrocodone

Bootsie · June 9, 2020

Norco (acetaminophen / hydrocodone) for Rheumatoid Arthritis: “This Mallinckrodt acetaminophen/hydrocodone generic Norco is absolute rubbish! I've complained to my doctor, to the pharmacy, to the FDA too many times to count, and to the company itself. I'm at my wit's end in pain! What is going on and how are they getting away with this? For 5 years I've been on this medication and when it was Watson brand it worked fine, didn't take away all the pain but it was better than what I am experiencing now! I'm seriously thinking about asking my doctor to switch me from 10 mg to 5 mg because someone said they worked great, maybe it's just the 10's that are junk. Tonight I am ordering some drug tests just to see if anything shows up because honest to god I am almost 100% positive there is not any active ingredients in the Mallinckrodt 10 mg. Why should I be crying in pain after taking 2???? ENOUGH. I am in the process of getting a chemical analysis of my medication. ”

1 / 10
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Bwayne66 · Taken for 2 to 5 years · July 12, 2021

Norco (acetaminophen / hydrocodone) for Back Pain: “I had 2 back surgeries in 2017 due to an injury. My personal physician prescribed me Norco 10/325 which was working Fantastic. However, I always had a problem getting refill and he always gave me the DEA story of how he didn't want to write the script. I finally went to a Pain Management clinic. Worse mistake I ever made! The pain management doctor treated me like an addict. I have never misused my pain medication. I got so frustrated that I stopped taking them. I have not had a good day since. And of course the pain management clinic won't return my calls. It's very sad that because some people have misused this medication and the government has stuck their hands in the doctor's office that people with legitimate pain has to suffer.”

9 / 10
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Frenchie · Taken for 10 years or more · July 7, 2021

Norco (acetaminophen / hydrocodone) for Pain: “I understand about the opioids crisis, BUT what about the elderly that go to doctor monthly and even get random drug tested? I have been on Norco for years for RA and also hardware that my body is rejected. All of a sudden these different manufactures brand of meds are given to us and the pharmacies do not tell us that they changed it. I’ve lost 10 pounds in 30 days because of being sick to my stomach. I can only take yellow Norco, but haven’t gotten it in over a year. Even when my do doctor requests it I I don’t get it. No one is carrying the yellow Norco. This not right. We are really hurting. We can’t get any relief!!!!”

10 / 10
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Buffy · Taken for 5 to 10 years · March 24, 2021

Norco (acetaminophen / hydrocodone) for Back Pain: “What is going on with the Norco pills these days? I've been getting the name brand Norco made by Allergan in the 7.5, when I filled my script this month, I swear they have no opiate in them and it's straight tylenol, I've been miserable this entire month, no relief at all, and I don't sleep at night due to RLS something isn't right. I used to take generic Watson never had an issue but when most pharmacy switched to that Mallinckrodt manufacturer I had to quit taking due to severe allergic reactions. So, after reading these comments I see I'm not the only one, now I don't know where to get meds refilled, pharmacies are doing something different for sure, these pills look the same but something is off, and they thought people would not notice, well I did right off the bat. Ridiculous”

1 / 10
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GandyDancer · Taken for 10 years or more · January 24, 2021

Norco (acetaminophen / hydrocodone) for Pain: “Train track worker 30+ years and am in pain - non cancer, non hospice palliative care pain. Stenosis.. Multiple Lumbar and thoracic disc nerve intrusions.. (herniated) Cervical Schmorls Nodes from the daily many hours of tool vibrations. Severe Heart Disease. High blood pressure from daily pain. What would happen if people on depression medication was cut off? Why are State Health Departments sending letters to doctors treating people with legitimate pain that can be seen and proven from medical testing while they are responsible to guard the medication they take because it is life saving to warn doctors about their prescribing? Doctors will not tell you about those letters. My guess is because pain medications give legitimate people with proven pain quality of life and keep them out of revolving doors in the medical community where salaries are very high. People in pain need a good law firm to bring class action suit against profits before compassion.”

3 / 10
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LAM · Taken for 10 years or more · April 2, 2021

Norco (acetaminophen / hydrocodone) for Back Pain: “CVS had generic Norco by Sun pharma NO vomiting, migraines, upset stomach. CVS had Aurobindo generic , pain was 8 after 2 tablets a 7, nausea bad. I wrote CVS CEO and he told pharmacist to order a brand that worked for me. Pharmacy manager got ANGRY and refused to fill my pain medication then she told my doctor, I had to go to pain management doctor. First visit the Dr came in said I read your chart you’ve had everything done to try and help your pain, so why are you here. I explained, I’m here because of a pharmacist, I explained he was shocked a pharmacist could do this and with all my surgeries. A pharmacist would complain about four pain pills a day. Dr wrote my RX added do not fill with Mallinckrodt, Aurobindo or Amneal . 2 years no problems last few months CVS said No Sun REALLY !! Every pharmacy refuses to order other brands and every pharmacy I call says we only carry Mallinckrodt .The FDA said if no one calls to complain , then things won’t change”

1 / 10
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Anonymous · Taken for 5 to 10 years · February 9, 2020

Norco (acetaminophen / hydrocodone) for Pain: “I can't understand why there aren't any more complaints , is everyone taking a generic Norco (acetaminophen and hydrocodone ) that actually works? If so please tell me what brand it is because the Tris brand has done something to their pills and they don't work at all anymore. I am no longer able to clean my home and barely can work part time. One of these sissy lawyers needs to step up and file a lawsuit for intentional pain and suffering because what these drug makers are doing is illegal and the FDA won't do their jobs. I have been filing complaints since last year. The FDA needs to be sued also. Tons of suicides already happened and more to come someone can only live in severe pain for so long. It feels like they just want to get rid of all the pain patients. I know they changed it because I saved a few old ones and half of one gives me relief. Please file complaints daily with the FDA and these vile drug companies who have no consciences.”

1 / 10
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Peggy sue · May 10, 2020

Norco (acetaminophen / hydrocodone) for Back Pain: “2 years agoI went to Walgreens instead of CVS and got my prescription filled that month for Norco 10 / 325 it was a pill look like my yellow ones little football but it was white. Absolutely did not work. I'm 67 years old and I had a horrible car accident 23 years ago and with the help of Norco I live with the pain. The last few years they're screwing with the medicine - everybody - not just Walgreens, Walgreens is the worst by the way. I believe that they are no longer putting opiate in their pills I mean if you get a 10 / 325 you shouldn't be able to break it so easily, used to be so hard to break that little yellow pill in half. I mean a lot of us are in pain if you're in pain why should we have to live in pain I don't get it. Somebody needs to do something I mean if anyone wants to go in together we find out how much it cost to test them I'll go in one way to find out”

3 / 10
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Magee1 · Taken for 10 years or more · July 21, 2021

Norco (acetaminophen / hydrocodone) for Pain: “Omg I didn't know so many people were going through this dilemma. I live in pain daily at a level 4. I don't take the Norco until the pain is a 7 or above. My Norco did fine and some days I could go for 2-3 days without taking anymore depending in my activity level. I have been screaming about these generics that don't work for years. First they took the real flexeril away which worked really well. Now they having taken the Norco away and given us some serious garbage. The sad part is this: us folks that suffer with chronic pain know the truth about these generics. They put us on them and tell us they are fine. People who use the drug to get high are not our problem. There's those of us who truly suffer with chronic pain. And it's sad that our government dies not give two-hoots about our conditions. I can't take those Percocet I'm allergic. They really don't care. The Norco worked. This rubbish they have now is a joke.”

2 / 10
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Roseland Rich · Taken for 10 years or more · July 2, 2021

Norco (acetaminophen / hydrocodone) for Back Pain: “I’m 72 years old with severe arthritis and sciatic nerve pain. I’ve been taking hydrocodone for over 20 years with excellent pain relief and able to live somewhat of a normal life. I cannot sleep on a regular mattress and for many years sleep in a recliner. Lately I’ve been helping my son and daughter-in-law babysitting my 3 grandsons which is not easy. As most the manufacturer is Mallincrkrodt. The script I just had filled is way different! The pain doesn’t subside and I literally feel very sick! While I normally feel pain relief and also more alert I now feel I can’t stay awake and honestly feel horrible! I’ve called all pharmacies and they all use nothing but Mallinckrodt! Also none of them have name brand Norco anymore! When I was getting Norco when colored yellow that worked the best. Since the change to white it’s never been the same.”

1 / 10
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BB97 · Taken for 10 years or more · June 13, 2021

Norco (acetaminophen / hydrocodone) for Pain: “I agree with EVERY comment in regards to Mallickrodt!!! They're horrible!!!! Ive used par/Qualitest forever with my double scoliosis and severe dibilitating arthritus. Now Par can't be found and..... Mallickrodt??? They do nothing!!!! What are we supposed to do besides suffer??”

1 / 10
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Imready · Taken for 5 to 10 years · July 2, 2020

Norco (acetaminophen / hydrocodone) for Pain: “I was diagnosed with Connective Tissue Disease about 9 years ago. Up until a couple years ago, I got excellent relief from a yellow generic Norco 5 325. It didn't always relieve all the pain but that's OK. I changed pharmacies twice now in hope of getting a product that made my life liveable. All I've gotten has been this ineffective m365. I took one over 2 hours ago and now do I finely feel like moving around, a big difference from getting relief in 20-30 minutes. The FDA is clearly negligent. They don't test generics for effectiveness at all. This witch hunt on Hydrocodone is a joke, with responsible hard working Americans paying the price in pain because of the who obtain these drugs illegally. The FDA just recently decided that cigars needed to be tested at $100k per test, but they refuse to test prescription medications prescribed by responsible care givers to tax paying Americans.”

3 / 10
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Johnny · Taken for 10 years or more · September 26, 2020

Norco (acetaminophen / hydrocodone) for Back Pain: “I screwed up my back pretty bad in 1993. The older I get the worse the pain. Surgery in NOT an option.. Used to get Watson and Qualitest brand acetaminophen/hydrocodone for the pain. It worked great. Then the pharmacies switched to Mallinckrodt. It either didn't work, made me itch or gave me severe breathing problems depending upon the lot number. My doctor switched me to Percocet. It didn't work at ALL! Then I checked the manufacturer. Mallinckrodt. If you can find a pharmacy the doesn't use Mallinckrodt...run, do not walk, to that pharmacy. I've had it with Mallinckrodt.”

1 / 10
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Screwed for life · Taken for 10 years or more · April 4, 2020

For Back Pain: “Due to a severe back injury I've been on Norco for years.. Long ago, my pharmacies carried Qualitest and Watson (dark yellow) brand. Worked great! Over the years, however, now they only carry Mallinckrodt brand. This stuff is hit or miss. I've also noticed that the Mallinckrodt brand is not only hit or miss, but I've developed an allergic reaction to the brand. Sometimes it causes itching and scratching, sometimes severe respiratory problems, or it doesn't work at all. My doctor says that I'm not the only one with this problem. Interesting. Has anyone else had these problems, or is it just me?”

5 / 10
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yogiredd · Taken for less than 1 month · June 10, 2021

Norco (acetaminophen / hydrocodone) for Pain: “I was baffled last weekend when I filled a new Norco 7.5/325 mg prescription after a Friday afternoon doctor visit and received zero effect from the pain I was experiencing passing a kidney stone. I tried taking the pills for over 2 days. The pharmaceutical company is Amneal. I have taken this drug over the years after having oral work done or post operatively, or from the last kidney stone episode 2 years ago and have always had very effective response to it. The second day I tried taking 2 pills at a time....nothing. I would not take anymore as I did not want to put something in my body that I had no idea what the content of it was. But it definitely wasn't any kind or level of opiate. I went online last weekend to seek information and found many similar complaints over the past several months. What a sad situation for people to find themselves in, being allowed to suffer in pain and being duped. Shame on these companies.”

1 / 10
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Anonymous · Taken for 10 years or more · June 22, 2019

Norco (acetaminophen / hydrocodone) for Back Pain: “I think I can help the government understand how patients feel about Norco Watson brand and the "others". Its like getting a pack of smokes and the store is out so they hand you some snuff and say" its the same thing." Or a doctor doing surgery and he asked for the knife and they hand him a steak knife and say "its the same thing" Or you go to buy a diamond and they pull out a selection from "Clairs" and say " its the same thing." Do you get it now?”

9 / 10
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Me · Taken for 5 to 10 years · January 19, 2020

Norco (acetaminophen / hydrocodone) for Pain: “This is an update the last 3 months of Tris brand of acetaminophen with hydrocodone (generic Norco) has felt like taking nothing. My new refill Friday of January 17 now feels like I'm taking a completely different medication this is not hyrdocodone in these pills!!! I am tired dizzy headache and a little upset stomach. These manufactures are doing some sort of testing on consumers using us as lab rats and its sickening. PLEASE PPL FILE COMPLAINTS WITH THE COMPANIES AND FILE COMPLAINTS WITH THE FDA ONLINE FORMS EVERY DAY UNTIL THEY GET INVESTIGATED.”

1 / 10
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Pain for 35 years · August 25, 2020

Norco (acetaminophen / hydrocodone) for Pain: “Fibro, CF, deg.arthritis, bilateral TJR of jaw. Have side effects to most meds, Norco works best. Generic Norco quality declined substantially since 2017. Used to take Qualitest generic 10/325 worked great, then Watson. Mallinckrodt, awful, did I mention AWFUL? Felt as I took nothing, nausea, & dizziness. Tried Par brand bad as Mallinckrodt. Dr. documents chart about lack of effectiveness of generic brands. Called small pharmacy, asked to order brand name Norco. Did this w/out any hassle or judgment.Costs $500 /100 , Rx is 180/ month. I pay $10 or less for generics. Good news brand name Norco works great, no side effects, pain 8 goes down to 3-4. Bad news can't afford. Req. ins co. cover, have documented generics give no pain relief. Think generic fillers are poor quality, & is why don't work for a lot of us in pain. Assume brand name have better quality fillers. It's unfair we have sub-par meds. Not all generics work as well as brand names, as they claim. Brand: Allergan, white, oblong, NORCO 539.”

9 / 10
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Jose · Taken for 10 years or more · June 19, 2019

Norco (acetaminophen / hydrocodone) for Pain: “I have been taking Norco the generic brand for 18 years due to back issues, but my doctor retired and a new doctor tells me that I have an addiction and that I need to stop taking it, so I asked him if he even read my file. I refuse to be in pain and was wondering if I any legal rights, I am 61 years old, worked hard in my younger age, got hurt on my job and now they tell me that I have an addiction ,I take 3 to 4 a day and I don't want to wither away due to pain the rest of my life.”

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Leo · August 7, 2020

For Pain: “I am a hard working citizen. I do not do recreational drugs or drink alcohol and yet I feel like I’m being treated like a vagrant getting the same medication I’ve been getting for years. The pharmacies are making it harder and harder , they push out refill dates every time , sometimes for weeks with the same excuse “Oh sorry our shipment didn’t come in”. Oh sorry! They aren’t the ones suffering in pain trying to make it through the day. Then they use Cheap products like the brand LUPIN. It’s awful. It gives me headaches, blurred vision, and dehydration. It’s worse than Aurobindo. I call, and call and call and and do tons of legwork on my own to make sure the pharmacist orders the right mfg and they get it wrong. I physically talk face to face and they still get it wrong. So at this point it feels intentional. The street users and addicts make it so horrible for the people who really need to use it to function. This has to change. :(”

2 / 10
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Harve · Taken for 5 to 10 years · June 4, 2020

Norco (acetaminophen / hydrocodone) for Back Pain: “The generic norco if today will be ineffective due to the abuse deterrence altering the effectiveness of the pain pill. Most of the pharmaceutical companies have been instructed to do this to avoid abuse, all the while not receiving any relief for those in pain.”

1 / 10
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Gman · February 11, 2020

Norco (acetaminophen / hydrocodone) for Back Pain: “Been on hydrocodone 20 years now. Life was great when six 10/325 yellow tabs worked 10 hour days. I was able to work and make great money (self employed contractor in home improvements)..bills paid...child support paid..life was great...then the proclaimed opioid crisis came. Pain management cut me down to four 10/325. Work went OK...(only 7 hour days)...then pain management cut me down again..(against my will )...down to four 7.5/325, then down to three 7.5/325 a day. Now I can only work 3 days a week for 3 hours. I am now behind on support orders, house payments, bills, taxes...and mind you..never abused them...don't drink..never did drugs (street illicit ). Always passed the urine tests for for meds...always passed pill counts...perfect pain management role model. My pain is all due to 3 motorcycle crashes, fell off roof (24 feet), tree fell on me, ran over by truck in 9th grade, so yeah a long history of injuries. Now about to loose everything I worked for last 20 years. The newest generics prescribe to me is PAR Pharmaceutical 7.5/325 and I don't even think there is any active ingredient in them..god bless”

7 / 10
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FakeDrugs2 · Taken for 10 years or more · March 9, 2022

For Pain: “Aurobindo hydrocodone 10mg/325 is NOT AB Rated for USA consumption. My opinion, it is a placebo, sugar pill with bad ingredients. Do not use Mallinckrodt. The solution is to order through your pharmacy Vicodin HP 10/300 bottles of 100. Your MD has to write specifically for this product made by Abbott in Chicago. The difference in a AB rated product is huge and meets all bioavailability requirements by the FDA.”

1 / 10
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Nurse55 · Taken for 10 years or more · May 21, 2020

For Back Pain: “I have been taking Hydrocodone for about 10 years. I have back issues(need surgery), an ankle that I had surgery on several years ago that gives me problems all the time and severe arthritis in my hands. I also have a bad left knee and rt. rotator cuff issues. My body is just beat up and worn out. Biggest reason is from being a Registered Nurse in the hospital setting for 20 years. Anyway, I noticed a change in the medication first time about a year ago. Then again about 3 months ago. The change(s) are VERY NOTABLE!! I have nausea, ringing in ears, less pain relief and dizziness so bad I feel like I have vertigo (which I don't..I had that checked). It is the Mallinckrodt mgfr. The fact they change the formulas on medications and don't let people know is terrible. Whether its dosage of the pain medication in it or fillers, it could potentially be a fatal issue if someone has allergy. The street addicts..ones that take any and everything to get high, has ruined true pain sufferers lives!!!”

5 / 10
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Me111 · Taken for 5 to 10 years · April 12, 2022

Norco (acetaminophen / hydrocodone) for Pain: “This is no longer like it contains hydrocodone. For the last 2 and 1/2 years these drug makers have been messing with the formula and it's like they're poisoning us using us as Lab rats and it's absolutely disgusting. My newest refill the same manufacturer I've been on for 5 years cause severe dizziness I couldn't even walk I was walking into walls it was so bad. Yep my doctor says I'm the only one with this complaint LOL are you people not reporting this to your doctor the drug maker and to the FDA? Wake up and start reporting this crap this is unbelievable that this is allowed to continue this long. Some of us still are forced to go to work and there's no way I can work like this I'm scared to death what I'm going to do now. And for you pharmacists who claim that dizziness is a side effect sorry when you're taking the same drug for 7 years it doesn't all the sudden start causing these severe side effects including sleepless, sleepiness, dizziness, headaches, rapid heart rate and nausea.”

1 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.