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Acetaminophen / hydrocodone Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acetaminophen / hydrocodone Tramadol Gabapentin
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acetaminophen / hydrocodone Tramadol Gabapentin
Prescription only

Acetaminophen/hydrocodone may be used to treat moderate-to-severe pain that is unrelieved by nonopioid analgesics. However, its use is limited by the dependence and addiction potential of the... View more

Prescription only

Tramadol is a strong pain relief medicine effective for both general and nerve-related pain. Tramadol can cause dependence and use may be limited by side effects such as nausea and... View more

Prescription only

Gabapentin may be used in the treatment of partial-onset seizures and nerve pain but is likely to cause dizziness or drowsiness. Gabapentin enacarbil (brand name Horizant), a prodrug of gabapentin... View more

More about Acetaminophen / hydrocodone More about Tramadol More about Gabapentin
Generic Status

Lower-cost generic is available

Lower-cost generic is available

Lower-cost generic is available
Ratings & Reviews

Acetaminophen / hydrocodone has an average rating of 6.0 out of 10 from a total of 1330 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 34% reported a negative effect.

Tramadol has an average rating of 6.9 out of 10 from a total of 1833 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 24% reported a negative effect.

Gabapentin has an average rating of 7.1 out of 10 from a total of 2482 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 21% reported a negative effect.

View all 1330 reviews

View all 1833 reviews

View all 2482 reviews

Drug Class
Side Effects

See also: acetaminophen / hydrocodone side effects in more detail.

See also: tramadol side effects in more detail.

See also: gabapentin side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 50 each
Dosage 325 mg-10 mg
Per Unit* $0.43
Cost* $21.52

View all acetaminophen / hydrocodone prices

Quantity 9 tablet
Dosage 50 mg
Per Unit* $1.29
Cost* $11.59

View all tramadol prices

Quantity 100 each
Dosage 300 mg
Per Unit* $0.24
Cost* $24.18

View all gabapentin prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Form(s) Available
  • Oral liquid
  • Oral solution
  • Oral tablet
  • Oral capsule, extended release
  • Oral liquid
  • Oral tablet
  • Oral tablet, extended release
  • Oral capsule
  • Oral solution
  • Oral tablet
Brand Names
Xodol, Zyfrel ConZip, Qdolo, Tramadol Hydrochloride ER Fanatrex, Gabarone, Gralise, Neurontin
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

3.8 hours

5.2 hours

6 hours
CSA Schedule ** View glossary of terms
2
High potential for abuse

Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
4
Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 619 drugs are known to interact with acetaminophen / hydrocodone:

  • 211 major drug interactions (776 brand and generic names)
  • 397 moderate drug interactions (1560 brand and generic names)
  • 11 minor drug interactions (39 brand and generic names)

A total of 655 drugs are known to interact with tramadol:

  • 304 major drug interactions (1148 brand and generic names)
  • 349 moderate drug interactions (1446 brand and generic names)
  • 2 minor drug interactions (5 brand and generic names)

A total of 266 drugs are known to interact with gabapentin:

  • 27 major drug interactions (146 brand and generic names)
  • 229 moderate drug interactions (991 brand and generic names)
  • 10 minor drug interactions (52 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Do not use alcohol or medications that contain alcohol while you are receiving treatment with... View more
  • Alcohol can increase the nervous system side effects of traMADol such as dizziness, drowsiness, and... View more
  • Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness... View more
Disease Interactions
First Approval Date

May 03, 1982

March 03, 1995

December 30, 1993
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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