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Acetaminophen / hydrocodone Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acetaminophen / hydrocodone Tramadol Gabapentin
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acetaminophen / hydrocodone Tramadol Gabapentin
Prescription only

Acetaminophen/hydrocodone may be used to treat moderate-to-severe pain that is unrelieved by nonopioid analgesics. However, its use is limited by the dependence and addiction potential of the... View more

Prescription only

Tramadol is a strong opioid pain relieving medication that may be used to treat moderate to severe general and nerve-related pain. Tramadol may be habit-forming and misuse can cause addiction... View more

Prescription only

Gabapentin is an anticonvulsant with pain-relieving effects that may be used to treat certain seizure disorders or relieve nerve pain. Common side effects include dizziness or drowsiness and it may... View more

More about Acetaminophen / hydrocodone More about Tramadol More about Gabapentin
Ratings & Reviews

Acetaminophen / hydrocodone has an average rating of 6.0 out of 10 from a total of 1315 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 35% reported a negative effect.

Tramadol has an average rating of 7.0 out of 10 from a total of 1877 ratings on Drugs.com. 62% of reviewers reported a positive effect, while 23% reported a negative effect.

Gabapentin has an average rating of 7.1 out of 10 from a total of 2574 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 21% reported a negative effect.

View all 1315 reviews

View all 1877 reviews

View all 2574 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Acetaminophen / hydrocodone side effects

View all Tramadol side effects

View all Gabapentin side effects
Drug Class
Generic Availability

Lower cost generic

Lower cost generic

Lower cost generic
Pricing and Coupons * Prices are without insurance
Quantity 50 each
Strength 325 mg-10 mg
Per unit* $0.47
Cost* $23.53

View all Acetaminophen / hydrocodone prices

Quantity 9 tablet
Strength 50 mg
Per unit* $1.34
Cost* $12.06

View all Tramadol prices

Quantity 100 each
Strength 300 mg
Per unit* $0.24 - $0.33
Cost* $23.69 - $33.10

View all Gabapentin prices

Get free Discount Card

Get free Discount Card

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Dosage Forms
  • Oral liquid
  • Oral solution
  • Oral tablet
  • Oral capsule, extended release
  • Oral liquid
  • Oral tablet
  • Oral tablet, extended release
  • Oral capsule
  • Oral solution
  • Oral tablet
  • Oral tablet, extended release
Brand Names
Xodol, Zyfrel ConZip, Qdolo, Tramadol Hydrochloride ER Fanatrex, Gabarone, Gralise, Neurontin
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

3.8 hours

5.2 hours

6 hours
CSA Schedule 1 View glossary of CSA terms
2
High potential for abuse

Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
4
Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 682 drugs are known to interact with Acetaminophen / hydrocodone:

  • 217 major drug interactions (801 brand and generic names)
  • 454 moderate drug interactions (1935 brand and generic names)
  • 11 minor drug interactions (39 brand and generic names)

A total of 712 drugs are known to interact with Tramadol:

  • 318 major drug interactions (1226 brand and generic names)
  • 391 moderate drug interactions (1571 brand and generic names)
  • 3 minor drug interactions (7 brand and generic names)

A total of 270 drugs are known to interact with Gabapentin:

  • 28 major drug interactions (148 brand and generic names)
  • 232 moderate drug interactions (1027 brand and generic names)
  • 10 minor drug interactions (52 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Do not use alcohol or medications that contain alcohol while you are receiving treatment with... View more
  • Alcohol can increase the nervous system side effects of traMADol such as dizziness, drowsiness, and... View more
  • Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness... View more
Disease Interactions
First Approval Date

May 03, 1982

March 03, 1995

December 30, 1993
WADA Class View classifications

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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