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User Reviews for Acetaminophen / hydrocodone to treat Rheumatoid Arthritis

Also known as: Norco, Lortab, Hycet, Lorcet, Anexsia, Xodol, Verdrocet, Duocet, Margesic H, Co-Gesic, Duradyne DHC, Hydrogesic, Lorcet HD, Lorcet Plus Hy-Phen Dolagesic Zyfrel Dolacet Theracodophen Low 90 Anolor DH5 …show all brand names

Acetaminophen / hydrocodone has an average rating of 4.9 out of 10 from a total of 66 ratings for the treatment of Rheumatoid Arthritis. 36% of reviewers reported a positive effect, while 53% reported a negative effect.

Acetaminophen/hydrocodone Rating Summary

4.9/10 average rating

66 ratings from 71 user reviews.

Compare all 305 medications used in the treatment of Rheumatoid Arthritis.

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Reviews for Acetaminophen / hydrocodone

Bootsie June 9, 2020

Norco (acetaminophen / hydrocodone): “This Mallinckrodt acetaminophen/hydrocodone generic Norco is absolute rubbish! I've complained to my doctor, to the pharmacy, to the FDA too many times to count, and to the company itself. I'm at my wit's end in pain! What is going on and how are they getting away with this? For 5 years I've been on this medication and when it was Watson brand it worked fine, didn't take away all the pain but it was better than what I am experiencing now! I'm seriously thinking about asking my doctor to switch me from 10 mg to 5 mg because someone said they worked great, maybe it's just the 10's that are junk. Tonight I am ordering some drug tests just to see if anything shows up because honest to god I am almost 100% positive there is not any active ingredients in the Mallinckrodt 10 mg. Why should I be crying in pain after taking 2???? ENOUGH. I am in the process of getting a chemical analysis of my medication. ”

1 / 10
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Sue · Taken for 10 years or more July 24, 2020

“I can tell you right now the Mallinckrodt hydrocodone has been changed ! I don’t think there is anything in them for pain , I believe they are taking it off market. I, for one, don’t know what I’m going to do. I’m 60 I’ve had 5 back surgeries, 1 neck surgeries I have been in pain for 13 years and have been taking the same dose for just as long ! I’m sick to my stomach , puke , I’ve had a cluster headache for over two months, dizzy, gain weight , tired all the time ! Why would the government do this to people that truly need this medication. I’m not a kid sneaking pills out of the medicine cabinet ! I wish I knew who to call about Mallinckrodt ! This stuff is nasty I’m worried there is something going into it that could really hurt us ! My god what can we do ?”

2 / 10
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Fritz June 8, 2020

“I suffer from rheumatoid arthritis and have been on Hydrocodone 10/325 for about 2 years, and when the generics stopped working, or made me sick, this website helped me find a brand that works. First, my bad experience was with Lupin (severe nausea and headache with little pain relief) and Mallinckrodt (which used to work but a few months ago stopped being effective). The yellow pills with the V on them are the only ones that work, they are made by Qualitest, which is now Par pharmaceuticals. None of the big retail pharmacy chains will order them. I called several local pharmacies until I found one who will order them and keep them in stock for me. They’re only open 5 days a week and I have to drive about 35-40 minutes round trip to get them, but it’s worth it. I hope this can help others, and thank you to those of you who recommended this brand to me. I finally have my quality of life back.”

9 / 10
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Annie · Taken for 5 to 10 years February 3, 2021

Norco (acetaminophen / hydrocodone): “I've been taking Norco for 10 years I've never had a problem but my pharmacy changed to this pharmaceutical company mallinckrodt and I'm literally taking one pill every four hours and it still doesn't work it takes 30 to 40 minutes for it to take effect so I sit here in pain. it just seems that there's something wrong with this drug I've never had a problem before I don't have an addiction to these pills I've been very careful only to take them when I need them.”

3 / 10
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Finn July 24, 2020

“I’ve been taking the generic Vicodin’s 7.5/ 325 for 15 years failed back surgeries. Walgreens is my pharmacy they changed brands from Watson to Mallinckrot and never told me I noticed I was sick to my stomach all the time and headaches tired , I didn’t know what the heck was going on. I got a refill on my inhaler they changed that, so I just looked at my pills what the heck they changed them too and didn’t tell me ! Damn now I have to deal with this for a month ! The pharmacist tried to tell me there is no difference in them and that just ticks me off , I don’t like being told something I know better !”

3 / 10
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Rasheia Rubey · Taken for 1 to 2 years October 26, 2021

“I have been an R.N. for the past 25 yrs. I have severe pain in my back, arms, knees and legs from R.A.. Most days I'm crying in severe pain and this terrible hydrocodone does nothing for my pain! It is inhumane to allow this kind I was prescribed oxy 30 mg & they always helped my pain and was able to work full time. I never took more than 2 to 3 a day. Pain management dr cut my prescription of oxycodone down and prescribed 4 to 6 of the 10 mg hydro/day. I have been in agony for the past year because of this med not helping me! Now I have severe ringing in my ears that never goes away! I thought maybe I had a tumor & had 3 MRI's to check my ears, my head and my arteries. Mind you I had to pay a 2K deductible. After reading all these other reviews I see I'm not alone. The FDA is obviously in on this charade or they don't just don't care. There's going to be a huge lawsuit against the FDA when this is uncovered! It IS inhumane 2 let people suffer like this, this is a crime.”

1 / 10
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pain weary senior · Taken for 10 years or more April 27, 2014

“I've had rheumatoid arthritis for 18 years with both hips and one knee replaced. I do very well and remain active on 5 Norco (10/325) in 24 hours. I rarely need it at night. Doctors are under pressure to reduce hydrocodone because they are prone to abuse. My doctor keeps trying to cut me back, first to 4 and next to 3. Nothing else works as well for me. It has less acetaminophen than Vicodin. I'm becoming depressed and less active because I can't control the pain. I wonder if others are experiencing this.”

10 / 10
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Sassafras May 1, 2020

“I have been on Vicodin, Norco, Hydrocodone-Acetaminophen off and on for about 11 years with RA, PA, AS, fibromyalgia, spinal stenosis, DDD, neuropathy...well let’s just say my spine is a mess and causing the rest of my body problems. I was on Watson brand at first 5/500 and even 7.5/750 and they worked great and I only took one every 8 hours, even though I was prescribed 1 every 6. In the last year or so I was switched to U03 I have noticed that I am taking them every 6 and I’m even taking my Neurontin (gabapentin 300) more often than I was. I really do agree with a lot of the reviews that there is a new formula or something being implemented by the FDA because I can take one and barely feel the relief I always used to. I know its taking the edge off, so I know its got something in it!”

4 / 10
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Wild Bill · Taken for 5 to 10 years February 28, 2020

“Ok so i agree with everyone about the changes to the pain pill formula. I have tried RP, and Mallinckrodt brand and they do absolutely nothing as far as giving me the overall pain relief. No real relief as they had before like Watson. Mallinckrodt used to be good but that was a long time ago. It’s almost like - might as well take an Aleve and a Tylenol. Problem with that is I have to take a lot of those often and then my kidneys and liver are hurting. Trashed my body even more. Mallinckrodt is better pain relief but nothing much better than Tylenol. There may be some formula out there to avoid the euphoria effect but without triggering that, it doesn't offer any of the pain benefits. Kind of like - have to have both or you get an alternative that does not actually work. But. Then people don't overdose so I get that also... Might be good for the addicts to stop but when I can't open a jar without excruciating pain or lift my arm, something has to give here. These brands all suck!!”

1 / 10
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bk · Taken for 1 to 6 months March 25, 2020

“I could tell a difference the first tablet I took; it gave me a stomach ache and made me feel almost lethargic after an hour or so. I thought my condition was maybe getting worse. I stopped taking the prescribed amount and just use it when needed; I felt awful for weeks. I got my new prescription of a different brand m365 and OMG I feel like me again without the side effects of this drug. I will be sure to let the pharmacy know that I can not take this brand to many different side effects.”

1 / 10
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What did they do? · Taken for 10 years or more July 7, 2019

“Ok so I have been on pain medication for 31 years, and I'm 38. I was first prescribed hydrocodone/acetominophin 7.5/500 at the age of 7 for RA. Well, those pills worked just fine, as an adult in my late twenties, I got by on two a day. When the pills changed to Norco, I was extremely unhappy. Today, I'm even worse. I'm a long term user. I can't help the length of time I have been on the medication. What happened to real 7.5 specks? They worked better than any 10mg Norco. I am now prescribed three a day as opposed to six. I am completely unhappy. In the past year, the tens by malinkroft have completely changed. The 5mg and 7.5mg strengths seem not to work. I can take two tens they simply no longer work. I have other health issues, a recent cancer diagnosis. Familial popylopus to be exact. My pain is ungodly. I want answers, that no one can provide. I can take this medication and feel withdrawals. That is the real epidemic. Lord help us all.”

5 / 10
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Ladybug November 24, 2019

“The Mallickrodt brand of acetaminophen with hydrocodone is the weakest, fake-est drug on the market. For the first time in over a year I finally got some that worked last month and I thought, great, they finally weeded out the garbage junk I've been getting for over a year when low and behold this month it's back to the junk. These pills are complete blanks, placebos, I am sure this is no active ingredients in them. Won't touch my pain no matter how many I take. They're white with M367 on them. FDA - Do YOUR JOB and STOP allowing this garbage on the market.”

1 / 10
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Buck June 7, 2020

“I have all the problems that everyone has with pain meds I feel the pain. I’ve been taking acetaminophen/hydrocodone 10/325 for years and switch between brands etc. But definitely the power in them has dropped. I’m taking m367 and gives me more of an itch than the relief. I need my pain meds to work I pay big bucks for my blue cross blue shield 4 meds and I argue wit my pharmacist bout this but goes nowhere. I talk for all patients like I heard they all worried about over dose, addiction and such. ”

3 / 10
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Lynn December 25, 2019

“I have been taking norco (acetaminophen with hydrocodone) for 10 yrs or more. Rite aid has decided to change to Camber pharmaceuticals the pills gave me no relief it felt like I had bugs crawling all over my body. Now I have to make sure my dr gives me brand Norco. I noticed the FDA does not quality test these drugs, they just leave it up to the companies to do their own testing!!!! How do we even know what is in this med? If any one else has the same problem we should stop all of our scripts from Rite aid...I heard they are going to get all their drugs from Camber pharmaceuticals which is based out of India.”

1 / 10
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Helene January 15, 2020

“I've had RA for 43 years. I started Vicodin in 1998 the reason my doctor put me on Vicodin I was taking too many over the counter Tylenol to help my rheumatoid arthritis. In 2006 my rheumatologist prescribed me Norcos because they said Norcos wouldn't harm my stomach. Now in 2020 it seems like a lot of people are complaining about overdosing on Norcos or morphine but I don't think that's fair I have a lot of pain and I'm pretty sure there's a lot of other people that have pain as well I don't think people should be judge and jury and especially the way the pharmacy treat their customers like you're a drug addict”

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D. March 17, 2021

Norco (acetaminophen / hydrocodone): “Feb 28,2021 I've been getting my prescription Norco 10/325 from CVS and lately they haven't been working on my pain. So I called my doctor and mention it they suggested I try a different pharmacy could be manufacturer so I did. I tried Walgreens worse decision because they gave me a brand called Mallinckrodt. It don't help at all with pain. I've had really horrible side effects bad weigh gain, head aches, depression, forgetfulness. Never again.”

1 / 10
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KnowsIt · Taken for 2 to 5 years November 29, 2019

“I have very serious pain and have been on this medication for 5 years. If you're given Mallinckrodt or Amneal brands, take my advice and throw it right in the trash. I truly believe they are putting, maybe, .01 mgs. per pill NOT 10 mgs. The FDA is clearly not doing their job, what a lousy government we have to let this happen in this day and age. I have researched and researched this medication to make sure it wasn't just me and every single medical site and chat site I visit it's been the same exact complaints as mine, thousands if not more of the same complaint - INEFFECTIVE. If you're given one of these brands you will NOT get one iota of relief from your pain. The FDA needs to do something about this, they're obviously NOT doing their job! WHY?”

1 / 10
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Dee · Taken for 5 to 10 years May 15, 2018

Vicodin (acetaminophen / hydrocodone): “I was born with a gene called hlab27+ . I have arthritis and consecutive tissue disorder. As a child I tried to play but got tired and too painful to stay up for long periods of time. I stayed in bed a lot. I tried to ride bikes with my friends as a teen but struggled. Until a Dr put me on pain meds in my 40s that I felt relief for the first time. Now the medical field is trying to reverse back. They need to hear the other side of the people that have been helped. It is not our fault if people are misusing their medication. I really do not believe this is the cause of the epidemic. Drunk drivers are caused by drinking too much and driving. If you don't over drink and you don't drive while drinking then there's no issue. Same thing here. I truly had no life before this pain medicine”

8 / 10
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Mikey · Taken for 10 years or more February 2, 2021

“I have suffered with the pain of chronic RA for the last ten years. This past month the Walmart pharmacy switched my hydrocodone to the brand Camber. They offer zero pain relief. Honestly I took a baby aspirin they gave me more pain relief that the 10 mg acetaminophen/hydrocodone camber brand. Maybe if these pharmacies pharmacists suffered from RA they would start demanding the manufacturers of these junk generic brands be tested because they cannot have any opioid pain medication in them. Suffering in the mountains.”

1 / 10
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cindar January 10, 2020

“Have been on hydrocodone/ acetaminophen 10mg/325 for 10 years. Always received the Watson brand. Then Watson stopped manufacturing hydrocodone and the pills that I have been getting in the past 4 months I (with my pharmacist help) have tried the following :Aurobindo, rhodes and tris pharma. They don’t work anymore. Also side effects of racing heart. I see others have the same problem. Does anyone have a brand that DOES work. How do you report this to the FDA. This is horrible. I am also on protonix for GERDs and this too has lost its effectiveness.”

1 / 10
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KP323 · Taken for 2 to 5 years May 30, 2012

Norco (acetaminophen / hydrocodone): “I've had back pain for years. Then I started getting really bad pain in my knee and found out I have Rheumatoid Arthritis and Osteoarthritis and I'm only 28 yrs old. I have been on Lortab 10/500 for 6 yrs. Then started going to a pain specialist and I'm now on Tramadol ER 300mg 1x a day and Norco 10/325 4-6x a day and it works miracles. I also take the muscle relaxer, Flexeril and it helps very well too. I still have pain but I always will for the rest of my life because of my arthritis. But these medicines makes life much better.”

10 / 10
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Lou August 26, 2019

“I totally agree w so many of the comments above. I got my pain meds from Walgreens (mallinckrodt brand) for a few years unfortunately my doc sent it to CVS by mistake and wouldn’t change it. I got the stubby oval ones (tryst) and had no pain relief. So when my next script was due I called the CVS store manager and he was very nice and specially ordered the Mallinckrodt brand for me no problem whatsoever. BUT I am having the same issues now with this brand now too. There seems to be something fishy going on. Please tell me what particular and has worked best for you. I am starting to get really tired of this.”

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Anonymous February 17, 2011

Vicodin (acetaminophen / hydrocodone): “I am 28 and have severe RA and fibromyalgia. I was on Darvocet which worked good. But then that was taken off the market. I've been on Vicodin for a little while now and it works wonders for me. Which is great since I'm up chasing my 5 yr old all day. It's the only other medicine I've tried that actually works.”

9 / 10
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Angel · Taken for 1 to 6 months November 11, 2019

“Using hydrocodone / acetaminophen 10/325 & it's not working. Last prescription not working, suggested my pain has increased. I purchased next prescription, no relief. Took two 10/325, no relief, & didn't make me sleepy. I believe it's the medication. I waited for the time for my next dose & instead took 800 mg of Motrin & a BC powder & got some relief. Waited for next time if medication dose, took 2 hydrocodone again, nothing. I was crying & in much pain. I've never taken pain meds my entire life until I was diagnosed with RA & SLE. This medication should be working for me but it isn't. I was admitted to the hospital for stomach issues & was given a hydrocodone 10/325 in the hospital, it knocked me out! I asked them to request an order from doctor to only take half of the hydrocodone while I in the hospital & the half hydrocodone in the hospital relieved my pain. I've read comments from internet, other people having same issues.”

1 / 10
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Captain America · Taken for 5 to 10 years January 17, 2020

Norco (acetaminophen / hydrocodone): “What’s everyone’s issue with Mallinkcrodt? I’ve been taking 10-325 for 5 years. When I don’t take them, I’m in tremendous pain. When I do take them, I am not. They work just fine for me... Take them as prescribed and with ibuprofen if necessary.”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

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