User Reviews for Acetaminophen / hydrocodone to treat Rheumatoid Arthritis
Brand names: Xodol Zyfrel
Acetaminophen / hydrocodone has an average rating of 4.6 out of 10 from a total of 76 reviews for the off-label treatment of Rheumatoid Arthritis. 34% of reviewers reported a positive experience, while 57% reported a negative experience.
Reviews for Acetaminophen / hydrocodone
"I can tell you right now the Mallinckrodt hydrocodone has been changed ! I don’t think there is anything in them for pain , I believe they are taking it off market. I, for one, don’t know what I’m going to do. I’m 60 I’ve had 5 back surgeries, 1 neck surgeries I have been in pain for 13 years and have been taking the same dose for just as long ! I’m sick to my stomach , puke , I’ve had a cluster headache for over two months, dizzy, gain weight , tired all the time ! Why would the government do this to people that truly need this medication. I’m not a kid sneaking pills out of the medicine cabinet ! I wish I knew who to call about Mallinckrodt ! This stuff is nasty I’m worried there is something going into it that could really hurt us ! My god what can we do ?"
"I suffer from rheumatoid arthritis and have been on Hydrocodone 10/325 for about 2 years, and when the generics stopped working, or made me sick, this website helped me find a brand that works. First, my bad experience was with Lupin (severe nausea and headache with little pain relief) and Mallinckrodt (which used to work but a few months ago stopped being effective). The yellow pills with the V on them are the only ones that work, they are made by Qualitest, which is now Par pharmaceuticals. None of the big retail pharmacy chains will order them. I called several local pharmacies until I found one who will order them and keep them in stock for me. They’re only open 5 days a week and I have to drive about 35-40 minutes round trip to get them, but it’s worth it. I hope this can help others, and thank you to those of you who recommended this brand to me. I finally have my quality of life back."
Norco (acetaminophen / hydrocodone) "Tried mallinckrodt, this is the worst hydrocodone pain tablet I have ever taken. I am a 73 yr old. Male, been taking 2 to 3 tabs a day for arthritis for 10 yrs. I had to get my pain therapist to change pharmacy to get something that worked. Taking. EYWA PHARMACEUTICALS 7.5 . They are the best I have had in a while. Stay away from Mallinckrodt unless you are into pain.."
Norco (acetaminophen / hydrocodone) "Have taken Norco 10/325 for years, for spinal stenosis and injured vertebrae pain. Within the last few years, generic was fine, and now, it has been tainted with who knows what. Amneal and Lupin pharmaceutical companies are two of the worst rubbish generic Norco. Getting away with selling poison, that doesn’t work. Watson, was one that did. What happened? The aforementioned should be investigated."
Are you taking this medicine?
"I've had rheumatoid arthritis for 18 years with both hips and one knee replaced. I do very well and remain active on 5 Norco (10/325) in 24 hours. I rarely need it at night. Doctors are under pressure to reduce hydrocodone because they are prone to abuse. My doctor keeps trying to cut me back, first to 4 and next to 3. Nothing else works as well for me. It has less acetaminophen than Vicodin. I'm becoming depressed and less active because I can't control the pain. I wonder if others are experiencing this."
Norco (acetaminophen / hydrocodone) "I've been taking Norco for 10 years I've never had a problem but my pharmacy changed to this pharmaceutical company mallinckrodt and I'm literally taking one pill every four hours and it still doesn't work it takes 30 to 40 minutes for it to take effect so I sit here in pain. it just seems that there's something wrong with this drug I've never had a problem before I don't have an addiction to these pills I've been very careful only to take them when I need them."
"I’ve been taking the generic Vicodin’s 7.5/ 325 for 15 years failed back surgeries. Walgreens is my pharmacy they changed brands from Watson to Mallinckrot and never told me I noticed I was sick to my stomach all the time and headaches tired , I didn’t know what the heck was going on. I got a refill on my inhaler they changed that, so I just looked at my pills what the heck they changed them too and didn’t tell me ! Damn now I have to deal with this for a month ! The pharmacist tried to tell me there is no difference in them and that just ticks me off , I don’t like being told something I know better !"
"In the last 2 years if not a little longer- these have turned into absolute JUNK..! Not nearly the same drug and feel in no way the same as they use to..! No More Than A Damn Placebo - Acetaminophen 325mg / 0mg Hydrocodone..! And they think the Placebo Effect Works on Everyone and I am Telling You They Do Not..! They DO NOT STOP God Awful Pain Of The Mornings nor do the Keep Pain From Overtaking You as you Sleep- go to sleep for only 1 or 2 hours after taking the drug at your bed time and I PROMISE you- you Won't hardly be able to move..!!! Sick and Tired of being lied to!!!"
"Ok so i agree with everyone about the changes to the pain pill formula. I have tried RP, and Mallinckrodt brand and they do absolutely nothing as far as giving me the overall pain relief. No real relief as they had before like Watson. Mallinckrodt used to be good but that was a long time ago. It’s almost like - might as well take an Aleve and a Tylenol. Problem with that is I have to take a lot of those often and then my kidneys and liver are hurting. Trashed my body even more. Mallinckrodt is better pain relief but nothing much better than Tylenol. There may be some formula out there to avoid the euphoria effect but without triggering that, it doesn't offer any of the pain benefits. Kind of like - have to have both or you get an alternative that does not actually work. But. Then people don't overdose so I get that also... Might be good for the addicts to stop but when I can't open a jar without excruciating pain or lift my arm, something has to give here. These brands all suck!!"
"I could tell a difference the first tablet I took; it gave me a stomach ache and made me feel almost lethargic after an hour or so. I thought my condition was maybe getting worse. I stopped taking the prescribed amount and just use it when needed; I felt awful for weeks. I got my new prescription of a different brand m365 and OMG I feel like me again without the side effects of this drug. I will be sure to let the pharmacy know that I can not take this brand to many different side effects."
"I have been on Vicodin, Norco, Hydrocodone-Acetaminophen off and on for about 11 years with RA, PA, AS, fibromyalgia, spinal stenosis, DDD, neuropathy...well let’s just say my spine is a mess and causing the rest of my body problems. I was on Watson brand at first 5/500 and even 7.5/750 and they worked great and I only took one every 8 hours, even though I was prescribed 1 every 6. In the last year or so I was switched to U03 I have noticed that I am taking them every 6 and I’m even taking my Neurontin (gabapentin 300) more often than I was. I really do agree with a lot of the reviews that there is a new formula or something being implemented by the FDA because I can take one and barely feel the relief I always used to. I know its taking the edge off, so I know its got something in it!"
"Ok so I have been on pain medication for 31 years, and I'm 38. I was first prescribed hydrocodone/acetominophin 7.5/500 at the age of 7 for RA. Well, those pills worked just fine, as an adult in my late twenties, I got by on two a day. When the pills changed to Norco, I was extremely unhappy. Today, I'm even worse. I'm a long term user. I can't help the length of time I have been on the medication. What happened to real 7.5 specks? They worked better than any 10mg Norco. I am now prescribed three a day as opposed to six. I am completely unhappy. In the past year, the tens by malinkroft have completely changed. The 5mg and 7.5mg strengths seem not to work. I can take two tens they simply no longer work. I have other health issues, a recent cancer diagnosis. Familial popylopus to be exact. My pain is ungodly. I want answers, that no one can provide. I can take this medication and feel withdrawals. That is the real epidemic. Lord help us all."
Vicodin (acetaminophen / hydrocodone) "I was born with a gene called hlab27+ . I have arthritis and consecutive tissue disorder. As a child I tried to play but got tired and too painful to stay up for long periods of time. I stayed in bed a lot. I tried to ride bikes with my friends as a teen but struggled. Until a Dr put me on pain meds in my 40s that I felt relief for the first time. Now the medical field is trying to reverse back. They need to hear the other side of the people that have been helped. It is not our fault if people are misusing their medication. I really do not believe this is the cause of the epidemic. Drunk drivers are caused by drinking too much and driving. If you don't over drink and you don't drive while drinking then there's no issue. Same thing here. I truly had no life before this pain medicine"
"The drug pharmacology is not effective in addressing pain. It’s not providing reliable relief of pain as the Teva pharma brand did. It has an entirely different effect drug even though it say the dosage is the same. I experience heart palpitations and extreme dizziness with their product. Don’t know what is added to their product to cause my body to not experience relief!!"
Norco (acetaminophen / hydrocodone) "I've had back pain for years. Then I started getting really bad pain in my knee and found out I have Rheumatoid Arthritis and Osteoarthritis and I'm only 28 yrs old. I have been on Lortab 10/500 for 6 yrs. Then started going to a pain specialist and I'm now on Tramadol ER 300mg 1x a day and Norco 10/325 4-6x a day and it works miracles. I also take the muscle relaxer, Flexeril and it helps very well too. I still have pain but I always will for the rest of my life because of my arthritis. But these medicines makes life much better."
"The Mallickrodt brand of acetaminophen with hydrocodone is the weakest, fake-est drug on the market. For the first time in over a year I finally got some that worked last month and I thought, great, they finally weeded out the garbage junk I've been getting for over a year when low and behold this month it's back to the junk. These pills are complete blanks, placebos, I am sure this is no active ingredients in them. Won't touch my pain no matter how many I take. They're white with M367 on them. FDA - Do YOUR JOB and STOP allowing this garbage on the market."
"I have been taking norco (acetaminophen with hydrocodone) for 10 yrs or more. Rite aid has decided to change to Camber pharmaceuticals the pills gave me no relief it felt like I had bugs crawling all over my body. Now I have to make sure my dr gives me brand Norco. I noticed the FDA does not quality test these drugs, they just leave it up to the companies to do their own testing!!!! How do we even know what is in this med? If any one else has the same problem we should stop all of our scripts from Rite aid...I heard they are going to get all their drugs from Camber pharmaceuticals which is based out of India."
"I've had RA for 43 years. I started Vicodin in 1998 the reason my doctor put me on Vicodin I was taking too many over the counter Tylenol to help my rheumatoid arthritis. In 2006 my rheumatologist prescribed me Norcos because they said Norcos wouldn't harm my stomach. Now in 2020 it seems like a lot of people are complaining about overdosing on Norcos or morphine but I don't think that's fair I have a lot of pain and I'm pretty sure there's a lot of other people that have pain as well I don't think people should be judge and jury and especially the way the pharmacy treat their customers like you're a drug addict"
Vicodin (acetaminophen / hydrocodone) "I am 28 and have severe RA and fibromyalgia. I was on Darvocet which worked good. But then that was taken off the market. I've been on Vicodin for a little while now and it works wonders for me. Which is great since I'm up chasing my 5 yr old all day. It's the only other medicine I've tried that actually works."
"I have all the problems that everyone has with pain meds I feel the pain. I’ve been taking acetaminophen/hydrocodone 10/325 for years and switch between brands etc. But definitely the power in them has dropped. I’m taking m367 and gives me more of an itch than the relief. I need my pain meds to work I pay big bucks for my blue cross blue shield 4 meds and I argue wit my pharmacist bout this but goes nowhere. I talk for all patients like I heard they all worried about over dose, addiction and such. "
Norco (acetaminophen / hydrocodone) "So I thought I would give everyone an update on what I found out. I called several pharmacies and most of them only carried the Mallinckrodt Norco. One pharmacist told me that is what they send him, making it seem like the insurance companies or someone else is controlling the market. As I said previously I was taking Watson brand (yellow football) and they worked very well and I never built a resistance to them. I called Walmart and they alternated between the Mallinckrodt and Cambridge. They currently had Cambridge in stock so I filled my prescription there. Of course they acted like I was a junkie but they filled them and I am happy to report they are working much like the Watson did. I actually cut back a pill a day and am taking 3 times a day and have much better pain relieve and motivation to work. You might give them a try and see if they are good for you"
"I have very serious pain and have been on this medication for 5 years. If you're given Mallinckrodt or Amneal brands, take my advice and throw it right in the trash. I truly believe they are putting, maybe, .01 mgs. per pill NOT 10 mgs. The FDA is clearly not doing their job, what a lousy government we have to let this happen in this day and age. I have researched and researched this medication to make sure it wasn't just me and every single medical site and chat site I visit it's been the same exact complaints as mine, thousands if not more of the same complaint - INEFFECTIVE. If you're given one of these brands you will NOT get one iota of relief from your pain. The FDA needs to do something about this, they're obviously NOT doing their job! WHY?"
"I have been taking hydrocodone for eight years for spinal degeneration and bone spurs. Walgreens use to have Watson brand hydrocodone. Then they switched to mallinckrodt. There version of hydrocodone is terrible. They are not nearly as effective at stopping my pain, they also put me in a terrible depressed mood. They also upset my stomach and even causing stomach pain. I had none of those issue in all the years of taking the Watson brand. Is mallinckrodt making hydrocodone weaker and what kind of fillers are they using that cause stomach problems"
"Have been on hydrocodone/ acetaminophen 10mg/325 for 10 years. Always received the Watson brand. Then Watson stopped manufacturing hydrocodone and the pills that I have been getting in the past 4 months I (with my pharmacist help) have tried the following :Aurobindo, rhodes and tris pharma. They don’t work anymore. Also side effects of racing heart. I see others have the same problem. Does anyone have a brand that DOES work. How do you report this to the FDA. This is horrible. I am also on protonix for GERDs and this too has lost its effectiveness."
Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.
Learn more about Rheumatoid Arthritis
Symptoms and treatments
Medicine.com guides (external)
More about acetaminophen / hydrocodone
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (1,318)
- Drug images
- Latest FDA alerts (11)
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: narcotic analgesic combinations
- En español
- Drug Information
- Hydrocodone and acetaminophen (Advanced Reading)
- Hydrocodone and Acetaminophen Liquid
- Hydrocodone and Acetaminophen Tablets and Capsules
Norco, Vicodin, Lortab, Lorcet, ... +11 more
Norco (acetaminophen / hydrocodone) "This Mallinckrodt acetaminophen/hydrocodone generic Norco is absolute rubbish! I've complained to my doctor, to the pharmacy, to the FDA too many times to count, and to the company itself. I'm at my wit's end in pain! What is going on and how are they getting away with this? For 5 years I've been on this medication and when it was Watson brand it worked fine, didn't take away all the pain but it was better than what I am experiencing now! I'm seriously thinking about asking my doctor to switch me from 10 mg to 5 mg because someone said they worked great, maybe it's just the 10's that are junk. Tonight I am ordering some drug tests just to see if anything shows up because honest to god I am almost 100% positive there is not any active ingredients in the Mallinckrodt 10 mg. Why should I be crying in pain after taking 2???? ENOUGH. I am in the process of getting a chemical analysis of my medication. "