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Acetaminophen / hydrocodone User Reviews & Ratings (Page 4)

Brand names: Xodol Zyfrel

Acetaminophen / hydrocodone has an average rating of 6.0 out of 10 from a total of 1,315 reviews on Drugs.com. 49% of reviewers reported a positive experience, while 35% reported a negative experience.

Reviews for Acetaminophen / hydrocodone

Commonly mentioned side effects
  • KTa...
  • Taken for 2 to 5 years
  • April 26, 2021

For Pain "I have been taking 5/325 mg and on occasion 7.5/325 mg generic Norco. I changed pharmacy one time and was given Mallinckrodt Pharmaceuticals brand (M366 on pill). I have had some psychological disturbances since starting this current round of meds from this company. Not sure if it is coincidence but I am extremely concerned!!! Someone, anyone who reads these reviews, can we investigate this company? I see other people have mentioned this as well. What is going on? Thank you."

7 / 10
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76 Report
  • Gan...
  • Taken for 10 years or more
  • June 23, 2022

Acetaminophen / hydrocodone for Pain "Mallinckrodt Norco is the only generic brand Walgreens carries. For the last 2-3 years, they have been rubbish. The Walgreens pharmacist tells me they cannot get any other brand. I have decided July 2022 will be my last AARP Walgreens Part D insurance premium payment, and I will drop the coverage. If anyone asks, I will explain one of my medications is nontherapeutic as the cause."

1 / 10
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57 Report
  • Eno...
  • Taken for 1 to 2 years
  • June 15, 2022

Acetaminophen / hydrocodone for Rheumatoid Arthritis "Have taken Norco 10/325 for years, for spinal stenosis and injured vertebrae pain. Within the last few years, generic was fine, and now, it has been tainted with who knows what. Amneal and Lupin pharmaceutical companies are two of the worst rubbish generic Norco. Getting away with selling poison, that doesn’t work. Watson was one that did. What happened? The aforementioned should be investigated."

1 / 10
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56 Report
  • Dre...
  • Taken for 10 years or more
  • June 13, 2023

Acetaminophen / hydrocodone for Pain "I used to take the colored Watson Norco, and it worked great, but ever since they switched to this white generic one, it doesn’t do anything for me and has been the same for friends. The Percocet still works, but not the hydrocodone."

3 / 10
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40 Report
  • kel...
  • Taken for 2 to 5 years
  • January 28, 2020

For Pain "Feeling sick for over a year now from hydrocodone ingredient change by the manufacturers. Heart racing, insomnia, chest pains. Where can we have these pills analyzed to tell what is in them? I clearly have suffered immensely. We just have to find a lab that is not paid off by the government."

1 / 10
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95 Report

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  • Jim...
  • Taken for less than 1 month
  • December 15, 2022

Acetaminophen / hydrocodone for Rheumatoid Arthritis "Tried Mallinckrodt. This is the worst hydrocodone pain tablet I have ever taken. I am a 73-year-old male, been taking 2 to 3 tabs a day for arthritis for 10 years. I had to get my pain therapist to change pharmacies to get something that worked. Taking EYWA Pharmaceuticals 7.5. They are the best I have had in a while. Stay away from Mallinckrodt unless you are into pain."

1 / 10
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47 Report
  • Ann...
  • Taken for 5 to 10 years
  • February 3, 2021

Acetaminophen / hydrocodone for Rheumatoid Arthritis "I've been taking Norco for 10 years. I've never had a problem, but my pharmacy changed to this pharmaceutical company Mallinckrodt, and I'm literally taking one pill every four hours, and it still doesn't work. It takes 30 to 40 minutes for it to take effect, so I sit here in pain. It just seems that there's something wrong with this drug. I've never had a problem before. I don't have an addiction to these pills. I've been very careful only to take them when I need them."

3 / 10
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74 Report
  • Edd...
  • Taken for 10 years or more
  • December 2, 2021

Acetaminophen / hydrocodone for Pain "Call the FDA to voluntarily report an AE event, such as the product not being AB rated anymore. Use NDC 00406-0125-01 on form 3500B from FDA.gov. Request proof from an independent lab assay that this NDA meets or exceeds 80/20 bioavailability. We need 100,000 reports to make the FDA listen to pain patients, we number nearly 77 million in the USA."

2 / 10
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  • Pat...
  • Taken for 5 to 10 years
  • March 25, 2023

Acetaminophen / hydrocodone for Pain "Norco is extremely effective - I have used it over the years after having 3 back surgeries. I have never experienced any negative side effects or withdrawal symptoms. Norco has been in use for over 60 years and has not caused a public health crisis. We have OxyContin to thank for that - a drug that should never have been approved. OxyContin is no more effective than Norco but is five times more addictive by design. The FDA should be ashamed of itself, and generic manufacturer Mallinckrodt should do us all a favor and go out of business. It is simply a waste unless you're looking for a medication that causes you to throw up. I would rate Norco a 10 and Mallinckrodt a 1. OxyContin is an abomination. Meanwhile, millions of us with moderate to severe pain every day have nowhere to turn."

10 / 10
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45 Report
  • Anonymous
  • October 27, 2009

Acetaminophen / hydrocodone for Pain "I started taking this after my knee surgery. I found it to be great. My recovery time was fast. I had no pain and lots of energy. It started with 3 or 4 pills a day, then after that it got to be 5 or 6 a day. I then had foot surgery. I had to take more for the pain to go away. This went on for 5 years. By the time I got help, I was taking 20 to 25 pills a day. I now know that God is watching over me because if he wasn't, I wouldn't be here now. I am now off of all painkillers, but it took a lot of hard work. I'm letting you know this because it creeps up on you before you even know it. Vicodin may help you at first and you may be able to control it. I thought I could. I'm just asking you, please be careful with this medicine."

10 / 10
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222 Report
  • Ber...
  • Taken for 2 to 5 years
  • June 3, 2022

Acetaminophen / hydrocodone for Pain "After reading some of these reviews, I am not alone. I actually thought maybe it's just me thinking the medicine doesn't work at times when I take it. WTH? What is going on? I have neck pain, neck fused with 2 cadaver discs. Now it's the back of my neck. The pain management center Dr. just lowered the dose quite quickly, I might add. Maybe because I'm on Medicare now, they got audited? I know that happens because I worked in a Dr. office! It's like no one cares about your chronic pain. Even after a tendon repair surgery on my hand, the nerve block wore off after 18 hrs. and it felt like my hand went through a tree shredder. I literally had to BEG for a few to get through at least 2 days after surgery. All because of an opioid crisis, thanks to the drug addicts. Now people who suffer genuine pain have to suffer."

6 / 10
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  • Fed...
  • Taken for 2 to 5 years
  • September 6, 2021

Acetaminophen / hydrocodone for Pain "Generic Norco used to work great when pharmacies carried the good quality brands, but now with the poor quality brands available, it is difficult to get pain relief. I am fed up with the so-called overdose epidemic causing chronic pain patients to suffer! States have sued the pharmaceutical companies over it, and as a result, the pharmaceutical companies filed bankruptcy and had to sell off their subcompanies that manufactured the good quality generics! Goodbye Watson, Qualitest, Par, Teva, etc.! Hello unrelieved crippling pain! I changed pharmacies from CVS, who dispensed worthless Caraco, to a private pharmacy who dispenses Amneal or Mallinckrodt. Mallinckrodt is very weak and causes terrible side effects, and Amneal works at about half strength. Tris from Walgreens doesn’t work at all! It’s so frustrating, we need pain relief and can’t get it anymore."

5 / 10
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  • Lol...
  • Taken for 2 to 5 years
  • July 14, 2019

For Back Pain "M367 is junk... I called the FDA and I need to fill out a formal complaint... I’m trying to get the yellow Par Pharm or Watson brands. They are messing with our meds and we need to stand up and fight. I’m miserable on these. Please, everyone who is getting this knockoff M367 Mallinckrodt Pharmaceuticals brand, report to the FDA. I’m suffering with fibromyalgia and multiple back issues and arthritis. If FDA employees had pain, we wouldn’t be having this issue."

1 / 10
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90 Report
  • Low...
  • Taken for 5 to 10 years
  • July 28, 2022

Acetaminophen / hydrocodone for Pain "These subpar bioequivalent generic pain meds are simply causing the ones who medically need pain relief to have to suffer. Why can't I have the opportunity to consult with my pain management doctor, get a prescription for a name brand pain medication, only to discover that the production of name brand is priced extremely expensive? This has resulted in the untreated severe chronic pain I have due to subpar bioequivalent generics flooding the pharmaceutical market. Hopefully, the truth behind this abomination will surface soon, and needless suffering will be addressed with compassion, not concerns of profits."

2 / 10
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50 Report
  • ezz...
  • Taken for 10 years or more
  • May 27, 2015

Acetaminophen / hydrocodone for Back Pain "I'm taking Norco 10/325 for over ten years on and off. I'm over sixty-five. I've recently come to the reality that this wonder drug has lowered my back pain, diabetes sugar, depression, and neuropathy pain. I've been told I have reverse side effects from this medication than the average patients the doctor attends to. Everyone else says, 'Oh, you're hooked on pain meds', so what. If they help all of these problems I have and have no bad side effects I can't live with. The best to this drug."

9 / 10
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129 Report
  • Anonymous
  • October 29, 2013

Acetaminophen / hydrocodone for Pain "Dating back to 1960, it seems like I've been plagued with pain every day of my life. Most of the time a small amount of aspirin will eliminate the issue. But there are days when almost nothing will end the pain. Since I began taking Norco 3-4 years ago - up to three, 10-325 mg tablets a day, life has been a genuine pleasure. I'm still experiencing daily pain. But it is very seldom severe. And when it is, that's only because I forgot I'm 74 years old and spent the day working in the yard like an 18 year old. I can't begin to name all the pain killers I've used in my life. But Norco is, by far, the most effective."

10 / 10
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155 Report
  • Tam...
  • Taken for 6 months to 1 year
  • October 20, 2022

Acetaminophen / hydrocodone for Back Pain "The generic Norco Mallinckrodt M367 for 8 months and never really helped pain. Even at the start. But in years past, I have had Norco 10/325 after 3 different surgeries, and I can say that they worked well for pain relief. Not these Mallinckrodt. Seems the formula is changed to satisfy the government's desires. Even some pharmacists agree but won't say publicly for fear of bucking the system. Today's generics appear to be inferior."

2 / 10
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  • Mrs...
  • Taken for 5 to 10 years
  • July 18, 2014

Acetaminophen / hydrocodone for Pain "I was diagnosed with Fibromyalgia about seven years ago. I have taken Norco as prescribed by my physician along with other medications. Norco has improved my quality of life 100% as it allows me to manage down my pain level so that I am capable of conducting everyday living without that heavy narcotic side effects i.e., feeling 'high', sleepiness, nausea, abdominal discomfort. I think I have developed a mild physical or mental dependence due to the length of time that I've been on the medicine. First and foremost I take the medicine as directed and I do not wait until my pain level is at a 10 before I act otherwise its effects are limited. Norco has been very helpful in giving me my life back!"

10 / 10
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141 Report
  • Anonymous
  • Taken for 5 to 10 years
  • March 1, 2020

Acetaminophen / hydrocodone "The past 3 or 4 months, every time I pick up my meds (10mg-325 hydrocodone with acetaminophen) it hasn't been working. I had the one imprinted with U03 (Aurolife Pharma LLC) when I started to notice I was having to double up due to the lack of effectiveness. So, I asked for a different manufacturer. I recently received a white oval with imprint 176 by the manufacturer 'Caraco Sun Pharma'. They are even worse! I usually take 1 every 4 or 5 hours, with these I've literally taken 2 at ONCE and NO relief. This whole scandal is rubbish, what are we supposed to do as patients for a resolution? Seriously!"

1 / 10
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  • Cur...
  • June 10, 2020

For Pain "This acetaminophen/hydrocodone Camber brand yellow pill with the number T259 (325 mg/10 mg). This must have come from the black market because it is worthless. I have to stay in pain all month long. It is wrong to have your insurance pay for this pill. No more for me. I have to find out what is in this pill. My pain is too great. Camber, fix this medication."

1 / 10
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  • Anonymous
  • March 19, 2008

Acetaminophen / hydrocodone for Pain "I have an unusual side effect to this drug. It takes the pain away (YEAH) but it also wires me. It should make me sleepy but it speeds me up. So not only is the pain gone but my house gets clean too. YEAH!"

10 / 10
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216 Report
  • Baz...
  • June 12, 2021

Acetaminophen / hydrocodone for Pain "This opioid is trash! I was prescribed it after a tonsillectomy, and it has provided zero relief. I’m 18 and have never taken pain pills in my life, so I definitely don’t have a tolerance, this stuff is just bogus. Thanks, gov’t, I’m glad I get to suffer for 2 weeks since you can’t give us pain relief!"

1 / 10
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65 Report
  • Col...
  • May 2, 2014

Acetaminophen / hydrocodone for Pain "I used to be on Vicodin 10/500 for my severe pain due to rheumatoid arthritis, psoriatic arthritis, fibromyalgia, and spinal issues. My pain is chronic and severe. I've been on Norco for 4 months now and did not feel any difference from the Vicodin. Last month, my pharmacy gave me a different brand. It was amazing! First time in a few years that my pain was less. I even found myself missing a dose because I was feeling okay. Believe me, all generics don't work the same way."

8 / 10
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152 Report
  • Dee...
  • Taken for 10 years or more
  • January 6, 2022

Acetaminophen / hydrocodone for Pain "I have taken this medication for 30 years, this is by far the worst! One month okay, the next month like I'm taking nothing! When Watson brand was available, I did not have this problem. It's extremely frustrating and painful!"

2 / 10
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55 Report
  • gre...
  • Taken for 10 years or more
  • April 6, 2019

For Back Pain "Acetaminophen with hydrocodone generic quality issues. I had thought having to switch back and forth (thru CVS filling prescription) of Qualitest generic, which is good, and the Mallinckrodt generic, which I had thought was the worst. Now I am in pain and no way to shop around, I have had to accept this. Now I have gotten to experience Aurobindo brand of Acetaminophen with hydrocodone, what a joke, and now 3 weeks in, depression has settled in. What in the world do they put in this stuff? At 72, I still work but if this is the brand I will be getting, then I have to admit I may have to quit work. There is a burning pain in the tissues that settles in by the end of the night, and the depression is getting more overwhelming, it seems. I just can't see why us long-term pain patients have to suffer. I don't care what problem they are having with abusers, it doesn't delete me nor my pain."

1 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.