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Acetaminophen / hydrocodone for Pain User Reviews

Brand names: Xodol Zyfrel

Acetaminophen / hydrocodone has an average rating of 6.2 out of 10 from a total of 708 reviews for the treatment of Pain. 52% of reviewers reported a positive experience, while 31% reported a negative experience.

Acetaminophen/hydrocodone rating summary

6.2/10 average rating

708 ratings from 748 user reviews.

Compare all 1448 medications used in the treatment of Pain.

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Reviews for Acetaminophen / hydrocodone

  • Frenc...
  • Taken for 10 years or more
  • July 7, 2021

Norco (acetaminophen / hydrocodone) "I understand about the opioids crisis, BUT what about the elderly that go to the doctor monthly and even get random drug tested? I have been on Norco for years for RA and also hardware that my body is rejected. All of a sudden, these different manufacturers' brands of meds are given to us, and the pharmacies do not tell us that they changed it. I’ve lost 10 pounds in 30 days because of being sick to my stomach. I can only take yellow Norco, but haven’t gotten it in over a year. Even when my doctor requests it, I don’t get it. No one is carrying the yellow Norco. This is not right. We are really hurting. We can’t get any relief!!!"

10 / 10
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649 Report
  • Gandy...
  • Taken for 10 years or more
  • January 24, 2021

Norco (acetaminophen / hydrocodone) "Train track worker 30+ years and am in pain - non-cancer, non-hospice palliative care pain. Stenosis. Multiple lumbar and thoracic disc nerve intrusions (herniated). Cervical Schmorl's nodes from the daily many hours of tool vibrations. Severe heart disease. High blood pressure from daily pain. What would happen if people on depression medication were cut off? Why are state health departments sending letters to doctors treating people with legitimate pain that can be seen and proven from medical testing while they are responsible to guard the medication they take because it is life-saving to warn doctors about their prescribing? Doctors will not tell you about those letters. My guess is because pain medications give legitimate people with proven pain quality of life and keep them out of revolving doors in the medical community where salaries are very high. People in pain need a good law firm to bring a class-action suit against profits before compassion."

3 / 10
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685 Report
  • Anonymous
  • Taken for 5 to 10 years
  • February 9, 2020

Norco (acetaminophen / hydrocodone) "I can't understand why there aren't any more complaints, is everyone taking a generic Norco (acetaminophen and hydrocodone) that actually works? If so, please tell me what brand it is because the Tris brand has done something to their pills and they don't work at all anymore. I am no longer able to clean my home and barely can work part-time. One of these sissy lawyers needs to step up and file a lawsuit for intentional pain and suffering because what these drug makers are doing is illegal and the FDA won't do their jobs. I have been filing complaints since last year. The FDA needs to be sued also. Tons of suicides already happened and more to come; someone can only live in severe pain for so long. It feels like they just want to get rid of all the pain patients. I know they changed it because I saved a few old ones and half of one gives me relief. Please file complaints daily with the FDA and these vile drug companies who have no consciences."

1 / 10
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774 Report
  • Magee
  • Taken for 10 years or more
  • July 21, 2021

Norco (acetaminophen / hydrocodone) "Omg, I didn't know so many people were going through this dilemma. I live in pain daily at a level 4. I don't take the Norco until the pain is a 7 or above. My Norco did fine, and some days I could go for 2-3 days without taking any more depending on my activity level. I have been screaming about these generics that don't work for years. First, they took the real Flexeril away, which worked really well. Now they have taken the Norco away and given us some serious garbage. The sad part is this: us folks that suffer from chronic pain know the truth about these generics. They put us on them and tell us they are fine. People who use the drug to get high are not our problem. There are those of us who truly suffer from chronic pain. And it's sad that our government does not give two hoots about our conditions. I can't take those Percocet I'm allergic to. They really don't care. The Norco worked. This rubbish they have now is a joke."

2 / 10
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397 Report
  • Imready
  • Taken for 5 to 10 years
  • July 2, 2020

Norco (acetaminophen / hydrocodone) "I was diagnosed with Connective Tissue Disease about 9 years ago. Up until a couple of years ago, I got excellent relief from a yellow generic Norco 5/325. It didn't always relieve all the pain, but that's okay. I changed pharmacies twice now in the hope of getting a product that made my life livable. All I've gotten has been this ineffective M365. I took one over 2 hours ago and now do I finally feel like moving around, a big difference from getting relief in 20-30 minutes. The FDA is clearly negligent. They don't test generics for effectiveness at all. This witch hunt on Hydrocodone is a joke, with responsible hard-working Americans paying the price in pain because of those who obtain these drugs illegally. The FDA just recently decided that cigars needed to be tested at $100k per test, but they refuse to test prescription medications prescribed by responsible caregivers to tax-paying Americans."

3 / 10
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442 Report

Are you taking this medicine?

  • BB97
  • Taken for 10 years or more
  • June 13, 2021

Norco (acetaminophen / hydrocodone) "I agree with EVERY comment in regards to Mallinckrodt!!! They're horrible!!!! I've used Par/Qualitest forever with my double scoliosis and severe debilitating arthritis. Now Par can't be found and... Mallinckrodt??? They do nothing!!!! What are we supposed to do besides suffer??"

1 / 10
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332 Report
  • Meano
  • Taken for 5 to 10 years
  • January 19, 2020

Norco (acetaminophen / hydrocodone) "This is an update. The last 3 months of Tris brand of acetaminophen with hydrocodone (generic Norco) has felt like taking nothing. My new refill Friday of January 17 now feels like I'm taking a completely different medication. This is not hydrocodone in these pills!!! I am tired, dizzy, have a headache, and a little upset stomach. These manufacturers are doing some sort of testing on consumers, using us as lab rats, and it's sickening. PLEASE, PEOPLE, FILE COMPLAINTS WITH THE COMPANIES AND FILE COMPLAINTS WITH THE FDA ONLINE FORMS EVERY DAY UNTIL THEY GET INVESTIGATED."

1 / 10
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393 Report
  • yogir...
  • Taken for less than 1 month
  • June 10, 2021

Norco (acetaminophen / hydrocodone) "I was baffled last weekend when I filled a new Norco 7.5/325 mg prescription after a Friday afternoon doctor visit and received zero effect from the pain I was experiencing passing a kidney stone. I tried taking the pills for over 2 days. The pharmaceutical company is Amneal. I have taken this drug over the years after having oral work done or post operatively, or from the last kidney stone episode 2 years ago and have always had a very effective response to it. The second day I tried taking 2 pills at a time, nothing. I would not take any more as I did not want to put something in my body that I had no idea what the content of it was. But it definitely wasn't any kind or level of opiate. I went online last weekend to seek information and found many similar complaints over the past several months. What a sad situation for people to find themselves in, being allowed to suffer in pain and being duped. Shame on these companies."

1 / 10
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282 Report
  • Jose
  • Taken for 10 years or more
  • June 19, 2019

Norco (acetaminophen / hydrocodone) "I have been taking Norco, the generic brand, for 18 years due to back issues. But my doctor retired and a new doctor tells me that I have an addiction and that I need to stop taking it. So, I asked him if he even read my file. I refuse to be in pain and was wondering if I have any legal rights. I am 61 years old, worked hard in my younger age, got hurt on my job, and now they tell me that I have an addiction. I take 3 to 4 a day and I don't want to wither away due to pain for the rest of my life."

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360 Report
  • Pain...
  • August 25, 2020

Norco (acetaminophen / hydrocodone) "Fibro, CF, deg. arthritis, bilateral TJR of jaw. Have side effects to most meds. Norco works best. Generic Norco quality declined substantially since 2017. Used to take Qualitest generic 10/325; worked great, then Watson. Mallinckrodt, awful, did I mention AWFUL? Felt as if I took nothing, nausea, and dizziness. Tried Par brand; bad as Mallinckrodt. Dr. documents chart about lack of effectiveness of generic brands. Called a small pharmacy, asked to order brand name Norco. Did this without any hassle or judgment. Costs $500 for 100; Rx is 180 per month. I pay $10 or less for generics. Good news, brand name Norco works great, no side effects, pain 8 goes down to 3-4. Bad news, can't afford. Require insurance coverage; have documented generics give no pain relief. Think generic fillers are poor quality, and this is why they don't work for a lot of us in pain. Assume brand name has better quality fillers. It's unfair we have sub-par meds. Not all generics work as well as brand names, as they claim. Brand: Allergan, white, oblong, NORCO 539."

9 / 10
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284 Report
  • Leo
  • August 7, 2020

"I am a hardworking citizen. I do not do recreational drugs or drink alcohol, and yet I feel like I’m being treated like a vagrant getting the same medication I’ve been getting for years. The pharmacies are making it harder and harder; they push out refill dates every time, sometimes for weeks with the same excuse 'Oh sorry, our shipment didn’t come in.' Oh, sorry! They aren’t the ones suffering in pain, trying to make it through the day. Then they use cheap products like the brand LUPIN. It’s awful. It gives me headaches, blurred vision, and dehydration. It’s worse than Aurobindo. I call, and call, and call, and do tons of legwork on my own to make sure the pharmacist orders the right manufacturer, and they get it wrong. I physically talk face-to-face, and they still get it wrong. So at this point, it feels intentional. The street users and addicts make it so horrible for the people who really need to use it to function. This has to change. :("

2 / 10
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277 Report
  • Me111
  • Taken for 5 to 10 years
  • April 12, 2022

Norco (acetaminophen / hydrocodone) "This is no longer like it contains hydrocodone. For the last 2 and 1/2 years these drug makers have been messing with the formula and it's like they're poisoning us using us as Lab rats and it's absolutely disgusting. My newest refill the same manufacturer I've been on for 5 years cause severe dizziness I couldn't even walk I was walking into walls it was so bad. Yep my doctor says I'm the only one with this complaint LOL are you people not reporting this to your doctor the drug maker and to the FDA? Wake up and start reporting this crap this is unbelievable that this is allowed to continue this long. Some of us still are forced to go to work and there's no way I can work like this I'm scared to death what I'm going to do now. And for you pharmacists who claim that dizziness is a side effect sorry when you're taking the same drug for 7 years it doesn't all the sudden start causing these severe side effects including sleepless, sleepiness, dizziness, headaches, rapid heart rate and nausea."

1 / 10
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145 Report
  • Inthe...
  • Taken for 1 to 6 months
  • August 23, 2020

Norco (acetaminophen / hydrocodone) "The generic hydrocodone/acetaminophen combo has turned into absolute garbage in the US. In my experience, pharmacies are just purchasing the cheapest product they can find, which increases all the bad effects of an opioid while providing very little pain relief. Opioids are the only drug class you can't even pay extra for the namebrand for, all thanks to pharmacy/insurance company policy. It is absurd. Honestly, it should be illegal. Luckily, my doctor is willing to switch me to Percocet or Oxy (which is almost impossible in today's age), so I'm glad. On the other hand, I seem to have a weirdly high tolerance to Oxy. Either way, reporting this to the drug manufacturers (Mallinckrodt, Tris, etc.) is the only way. The FDA is filled with people who don't answer the phone, so reporting to the manufacturers as well is best."

2 / 10
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215 Report
  • Bring...
  • Taken for 10 years or more
  • November 20, 2019

Norco (acetaminophen / hydrocodone) "When the Watson brand of acetaminophen/hydrocodone was available, this medication was wonderful. The last 2 months, I noticed a difference in my prescription not working effectively. I honestly could feel little to no relief and excessive drowsiness throughout the day. I called the pharmacy and found out the manufacturer was Mallinckrodt. After reading reviews about others taking this brand, I have decided to talk to my pain specialist and switch medications rather than try to search for a pharmacy with a different brand. Good luck to you all, and I pray that we all get some relief from ongoing pain. #Peaceandlove"

3 / 10
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240 Report
  • JBano
  • March 17, 2020

Lortab (acetaminophen / hydrocodone) "This pill didn't do much of anything before, but nowadays they do even less. Are they doing something to the pain meds so that they are not consistent ever? Some months, you get a script that's amazing, and other times they make you feel so bad your head hurts, etc. But the feds and gov have their hands in everything, so I'm sure they're knocking everything off so can't trust any of them anymore. It is nothing like it used to be."

1 / 10
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209 Report
  • Pharm...
  • Taken for 10 years or more
  • March 6, 2022

Norco (acetaminophen / hydrocodone) "Please send a MEDWATCH 3500 form to the FDA about Norco generic. FDA dot GOV The FDA will not read your post here. Medwatch 3500 form is a simple one page document that will help the FDA open an investigation on the generic manufacturers. NORCO generic is NOT AB Rated! Available USA generics are AA rated, meaning they only passed a dissolution test in acetone with a report that has been submitted to the FDA. This does NOT mean it is therapeutically equivalent to the reference brand. That is why you are experiencing more pain, that is because these manufacturers are NOT making therapeutically equivalent drugs that you are taking. Again, they are NOT AB Rated. Currently there is no open investigation on generic Norco! You have to submit the Medwatch 3500 Form! This exists because we need people on this site to submit a FDA Medwatch 3500 Form via mail, FAX or Email, then if enough complaints are logged, then only then will there will be action. Please act now, send the Form"

1 / 10
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112 Report
  • Suki
  • April 24, 2021

Norco (acetaminophen / hydrocodone) "Absolute garbage. Ibuprofen works better for my tooth pain. I ended up doubling my dose and still no relief. I don’t know what the manufacturers are doing to pain pills these days but it’s wrong on so many levels."

1 / 10
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137 Report
  • Pain...
  • Taken for 10 years or more
  • November 18, 2018

Norco (acetaminophen / hydrocodone) "I have been on Norco for 13 years for pain relief and have no side effects. The main problem is finding a doctor to prescribe them. Many doctors mistakenly think by cutting down or stopping writing scripts for Norco, there are less overdoses. Actually, the people that legitimately take it for pain are suffering, and the people abusing it have switched to heroin, which there are many more ODs from. Heroin is not controlled so it can contain deadly ingredients; also, an addict could be used to a certain strength and unknowingly buy something stronger that could kill them. This law has caused more deaths, but most doctors haven't done the research I have and don't know this. I think the doctors should get personally involved with the patients; I would gladly answer any questions and give permission for them to check my legal history. Then hopefully the people in pain would get help and the people abusing drugs could go to rehab to get off it. That's when we'll see a drop in ODs and deaths."

10 / 10
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194 Report
  • Arkan...
  • Taken for 10 years or more
  • January 16, 2021

"The old yellow hydros with the checkmark were the best for helping my chronic pain. Now all pharmacies have the mallinckrodt M367 white ones which may as well be sugar pills. Very little effect if any, the government just can't stop hurting all of us who actually need pain medicine due to all the other people overdosing. No idea how the FDA hasn't done anything about this!!! Terrible!!"

2 / 10
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128 Report
  • Jasmine
  • Taken for 10 years or more
  • July 16, 2019

"I'm a pharmacist with migraines and have been taking Watson brand Norco 10/325mg for 10 years. Usually, a 1/2 tab is plenty or 1 tab, if needed. 60 tabs lasts me a year. Just got 30 tabs made by Lupin. An hour after taking 1, I felt like I hadn't taken anything, so I took another. I have never had to take 2! Still no relief. No difference between the different brands? As a pharmacist, who is definitely not addicted or dependent since I rarely take it, I'm telling you this isn't true. I'd like to test the 2 brands' ingredients and the quantities of each. If they have the same amount of active ingredients, the issue could then be the inactive ones. The Lupin brand works for some, but is it because that was the 1st brand they had taken or is it because some people's bodies process inactive ingredients differently? The Lupin brand doesn't work for me and others and it isn't fair that we must suffer because this is the only brand the pharmacy will dispense."

1 / 10
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151 Report
  • Kraci
  • Taken for less than 1 month
  • January 12, 2019

Norco (acetaminophen / hydrocodone) "I have had times when I've had to take Norco for pain. Most of which was Watson. I had knee surgery Dec 28 and was given Norco 5/325 from Aurobindo pharmaceuticals. I took 2-3 at a time to feel ANY RELIEF. This brand is no better than OTC meds. I never knew until now that different companies use different ingredients. I'm so disappointed in my pharmacy for changing companies at the cost of their suffering clientele."

1 / 10
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150 Report
  • FakeD...
  • Taken for 10 years or more
  • March 9, 2022

"Aurobindo hydrocodone 10mg/325 is NOT AB Rated for USA consumption. My opinion, it is a placebo, sugar pill with bad ingredients. Do not use Mallinckrodt. The solution is to order through your pharmacy Vicodin HP 10/300 bottles of 100. Your MD has to write specifically for this product made by Abbott in Chicago. The difference in a AB rated product is huge and meets all bioavailability requirements by the FDA."

1 / 10
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76 Report
  • Jillyn
  • Taken for less than 1 month
  • April 4, 2020

"My GYN prescribed this for me on 4/2/20, for ovarian cysts as he's done a couple of other times in the past, when the ER doesn't want to help with pain control. I'm in pain management & despite my pain Dr ok'ing me receiving pain meds in emergency situations, from Dr's other than him, some ER Dr's don't want to be bothered with my quality of life & doing the right thing . In the past, I'm not sure who the manufacturer was, but, it was effective. With this particular brand, Mallinckrodt, it's not as effective & I've noticed it feels like I've taken some sort of sedative. This hasn't happened before & when I looked this up & found these reviews, I knew I had to share my experience. I also looked up Mallinckrodt & read where they've been in some legal trouble for ethical behavior concerning another one of their meds, so, I wouldn't be surprised if they weren't putting the correct doses of ingredients in these."

3 / 10
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113 Report
  • BB97
  • June 3, 2021

"I have severe 50 degree upper scoliosis and 40 degree lower scoliosis. I've used Par/Qualitest brand 10/325 and it worked awesome. This Mallinckrodt brand of acetaminophen and hydrocodone is awful!!! I agree with EVERYONE on this comment. We NEED PAR/QUALITEST brand back and dump Mallinckrodt!!! Now because of all the pain pills being wrongly used by people, us poor suffering people with proof of our conditions, we are SUFFERING!!! Something has got to change!! We NEED relief and Mallinckrodt brings none!!! Wheres Qualitest???"

10 / 10
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88 Report
  • Real...
  • Taken for 2 to 5 years
  • September 13, 2021

Norco (acetaminophen / hydrocodone) "With brand Norco or Watson Hydrocodone at one a day I experienced occasional itchy nose, occasional mild nausea, occasional constipation. Now at six mallinckrodt brand hydrocodone I have no side effects? Along with minimal pain relief.. Billions of dollars are being spent on these inferior drugs. Peoples money, insurance companies, tax payers money in the trash and people suffering! What a joke the FDA is. Time for a federal lawsuit against the FDA and Mallinckrodt as well as anyone else who stood by while this is going on. This is not the solution to a few bad apples that misuse/abuse their medication. There are much more people who have been using it responsibly and it's not hard to decipher the addicts from the people who want to be able to live their lives without agony and depression from constant pain. It may be sad when abusers overdose but it's worse when honest deserving patients give up due to no pain relieve ."

1 / 10
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81 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.