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Ultracet

Pronunciation

Generic Name: acetaminophen and tramadol (a SEET a MIN o fen and TRAM a dol)
Brand Names: Ultracet

What is Ultracet?

Ultracet contains a combination of tramadol and acetaminophen. Tramadol is a narcotic-like pain reliever. Acetaminophen is a less potent pain reliever that increases the effects of tramadol.

Ultracet is used to treat moderate to severe pain.

Ultracet may also be used for purposes not listed in this medication guide.

Important information

You should not use Ultracet if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.

Tramadol can slow or stop your breathing, and may be habit-forming. Use only your prescribed dose. Never share Ultracet with another person.

An acetaminophen overdose can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).

MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

Before taking this medicine

You should not use Ultracet if you are allergic to acetaminophen (Tylenol) or tramadol (Ultram), or if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.

Seizures have occurred in some people taking Ultracet. Your risk of a seizure may be higher if you have any of these conditions:

  • a history of drug or alcohol addiction;

  • a history of epilepsy or other seizure disorder;

  • a history of head injury;

  • a metabolic disorder;

  • an infection of your brain or spinal cord, such as meningitis or encephalitis;

  • if you use a sedative like Valium (diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others); or

  • if you have taken an MAO inhibitor (isocarboxazid, linezolid, methylene blue injections, phenelzine, rasagiline, selegiline, tranylcypromine) within the past 14 days.

Some medicines can interact with tramadol and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

To make sure Ultracet is safe for you, tell your doctor if you have:

  • liver disease, cirrhosis, a history of alcoholism, or if you drink more than 3 alcoholic beverages per day;

  • kidney disease;

  • asthma or other breathing disorder;

  • a stomach disorder;

  • a history of depression, mental illness, or suicide attempt; or

  • if you use a sedative like Valium (diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others).

It is not known whether Ultracet will harm an unborn baby. If you use the medicine while you are pregnant, your baby could become dependent on tramadol. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.

Acetaminophen and tramadol can pass into breast milk and may harm a nursing baby. You should not breast-feed while using Ultracet.

How should I take Ultracet?

Take Ultracet exactly as prescribed by your doctor. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. An overdose can damage your liver or cause death. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

The maximum amount of Ultracet is 2 tablets per dose, or 8 tablets per day. Do not take Ultracet for longer than 5 days in a row.

Ultracet may be habit forming. Never share it with another person. MISUSE OF NARCOTIC PAIN MEDICATION CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away this medicine is against the law.

You may take Ultracet with or without food, but take it the same way each time.

Do not stop using Ultracet suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using the medicine.

Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Ultracet is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Ultracet dosing information

Usual Adult Dose for Pain:

Usual dose: 2 tablets every 4 to 6 hours as needed for pain
Maximum dose: 8 tablets per day
Maximum duration: 5 days

Comments:
-Each tablet contains Tramadol 37.5 mg and Acetaminophen 325 mg. Maximum daily doses are Tramadol: 300 mg per day and Acetaminophen 2600 mg per day.
-Use of more than 1 product at time containing acetaminophen is not recommended.

Use: For the short-term management of acute pain; use should be limited to 5 days or less.

Usual Geriatric Dose for Pain:

Dose selection should be cautious due to potential for greater sensitivity to adverse events.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Since Ultracet is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An Ultracet overdose can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include shallow breathing, slow heartbeat, extreme weakness, cold or clammy skin, feeling light-headed, fainting, seizure, or coma.

What should I avoid while taking Ultracet?

Do not drink alcohol. Dangerous side effects or death could occur.

Ultracet may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose.

Ultracet side effects

Get emergency medical help if you have signs of an allergic reaction to Ultracet: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking Ultracet and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Like other narcotic medicines, tramadol can slow your breathing. Death may occur if breathing becomes too weak.

Stop using Ultracet and call your doctor at once if you have:

  • shallow breathing, slow heartbeat, weak pulse;

  • a light-headed feeling, like you might pass out;

  • confusion, agitation, hallucinations, unusual thoughts or behavior;

  • fever, fast heart rate, overactive reflexes, vomiting, diarrhea, loss of coordination;

  • seizure (convulsions);

  • easy bruising or bleeding;

  • infertility, missed menstrual periods;

  • impotence, sexual problems, loss of interest in sex;

  • liver problems - nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

  • low cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common Ultracet side effects may include:

  • dizziness, drowsiness, weakness, tired feeling;

  • stomach pain, constipation, loss of appetite;

  • dry mouth, blurred vision;

  • feeling nervous or anxious;

  • sweating, itching; or

  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Ultracet?

Narcotic (opioid) medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

  • other narcotic medications - opioid pain medicine or prescription cough medicine;

  • drugs that make you sleepy or slow your breathing - a sleeping pill, muscle relaxer, sedative, tranquilizer, or antipsychotic medicine; or

  • drugs that affect serotonin levels in your body - medicine for depression, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting.

This list is not complete. Other drugs may interact with acetaminophen and tramadol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about Ultracet.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Ultracet only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 7.04.

Date modified: November 03, 2016
Last reviewed: September 29, 2016

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