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Generic name: bupivacaine and meloxicambue-PIV-a-kane-and-mel-OX-i-kam ]
Drug class: Analgesic combinations

Medically reviewed by on Apr 2, 2024. Written by Cerner Multum.

What is Zynrelef?

Zynrelef is used in adults to relieve pain for up to 72 hours after certain surgical procedures.

Zynrelef may also be used for purposes not listed in this medication guide.

Zynrelef side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Zynrelef may cause serious side effects. Call your doctor at once if you have:

Common side effects of Zynrelef may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Zynrelef can increase your risk of fatal heart attack or stroke. Do not use Zynrelef just before or after heart bypass surgery (coronary artery bypass graft, or CABG). This medicine may also cause stomach or intestinal bleeding, which can be fatal.

Before taking this medicine

You should not use Zynrelef if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Zynrelef can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Zynrelef may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.

Zynrelef is not used as an anesthetic in tissues around the cervix.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or plan to become pregnant. Zynrelef may harm an unborn baby if used at 20 weeks or later in pregnancy. If you are between 20 to 30 weeks of pregnancy, only use this medicine if your doctor has told you to. Avoid using this medicine if you are more than 30 weeks pregnant.

Tell your doctor if you are breastfeeding.

How is Zynrelef given?

Zynrelef is administered by a healthcare professional. You will receive Zynrelef in a medical setting.

Zynrelef causes temporary loss of sensation near the surgical site.

Your breathing, blood pressure, or other vital signs will be watched closely.

What happens if I miss a dose?

In a medical setting you are not likely to miss a dose.

What happens if I overdose?

Since Zynrelef is given in a medical setting, you will be watched closely to make sure you do not receive too much of Zynrelef. Your healthcare provider will quickly treat you if you have overdose symptoms.

What should I avoid while receiving bupivacaine and meloxicam?

Avoid drinking alcohol. Heavy drinking can increase your risk of stomach bleeding.

Avoid taking aspirin while you are using Zynrelef, unless your doctor tells you to.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to Zynrelef (such as aspirin, ibuprofen, ketoprofen, or naproxen).

What other drugs will affect Zynrelef?

Tell your doctor about all your other medicines, especially:

This list is not complete and many other drugs may affect Zynrelef. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.