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User Reviews for Acetaminophen / diphenhydramine

Also known as: Tylenol PM, Headache Relief PM, Legatrin PM, Percogesic Original Strength, Percogesic Extra Strength, Pain Reliever PM, Midol PM, Excedrin PM, Mapap PM, Bayer Select Max Strength Night Time Pain, ConRx PM, Acetadryl, Night Time Pain, Unisom PM Pain, Genapap PM, Counteract PM Extra Strength, Wal-Nadol PM Extra Strength, Headache Formula PM, Tylenol Sore Throat Nighttime, Pharbetol PM Non-Aspirin PM Extra Strength Acetaminophen PM Extra Strength Anacin PM Aspirin Free …show all brand names

Acetaminophen / diphenhydramine has an average rating of 7.1 out of 10 from a total of 61 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 25% reported a negative effect.

Condition Avg. Rating Reviews Compare
Insomnia  
6.1
29 reviews 106 medications
Headache  
7.1
17 reviews 221 medications
Pain  
8.8
15 reviews 1127 medications
Summary of Acetaminophen / diphenhydramine reviews 7.1 61 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Acetaminophen / diphenhydramine

Insomniac · Taken for 10 years or more June 6, 2019

Tylenol PM (acetaminophen / diphenhydramine) for Insomnia: “I have used Tylenol PM for a long time to help me fall asleep. Unlike Benadryl, this med actually keeps me asleep as well. However, the BEST effect from Tylenol PM is the dreams. I have had the most wonderful dreams.”

10 / 10
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Jonathan H · Taken for 1 to 6 months September 10, 2020

Tylenol PM (acetaminophen / diphenhydramine) for Insomnia: “I have severe back pain everyday. Just had back fusion surgery in May. It's difficult to get comfortable at night in order to fall asleep. However, after taking two Tylenol PM (the recommended dose) within the hour I'm comfortable enough to doze off. I stay asleep for 6-10 hours most nights. Without it I would maybe get a few hours a night if I was lucky. Hope it works well for everyone else!”

9 / 10
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Cyd · Taken for less than 1 month May 16, 2020

Tylenol PM (acetaminophen / diphenhydramine) for Insomnia: “It’s pretty effective at helping me sleep, I’m down for usually 10-12 hours. I usually get bad side effects from any medication I’m on, so here are the ones I’ve had. Feeling lightheaded, numbness in feet and legs, heart palpitations, blurred vision. Some of this may be my existing medical conditions but it’s worth mentioning. I don’t think I’d recommend taking this for a long amount of time?? I’m only using it to help me through the rest of school.”

4 / 10
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agapeins April 28, 2016

Tylenol PM (acetaminophen / diphenhydramine) for Insomnia: “The Tylenol PM worked .... TOO GOOD! After 20 minutes I would have a great night's sleep. I have been taking it for years .... then my son told me the new reports about this causing dementia. I stopped immediately. The side effects after I stopped have been pretty severe. I never dreamt that there would be withdrawals from this until I googled it but I have most of the symptoms (except for the shakes and nightmares).... dizzy, light headedness, nausea, unable to sleep. After all I thought, since I talked to my doctor over and over about them (and he said no problem) and they were over the counter, I was good. WRONG! Bad stuff. Tell everyone you know to stop them.”

3 / 10
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Anonymous October 24, 2012

Tylenol PM (acetaminophen / diphenhydramine) for Insomnia: “When I take this medication I sleep through the night with no pain but wake up restless and feeling anxious and nervous all day. Also I get heart palpitations and difficult breathing. You have to be careful with this over the counter medication.”

1 / 10
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Winnny January 26, 2013

Tylenol PM (acetaminophen / diphenhydramine) for Insomnia: “I've been taking this med - or just the Benadryl, which is the sleep inducing part of Tylenol PM - for several years now, as needed. It definitely helps me to fall asleep more easily when I might otherwise lay awake for an hour or two. I did notice that it seems to loose its effectiveness somewhat if I use it too frequently. I've had no noticeable side effects.”

8 / 10
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BritTex September 29, 2008

Tylenol PM (acetaminophen / diphenhydramine) for Insomnia: “I've taken other prescription sleep medications in the past but they do tend to make your drowsy and have all sorts of side effects. I suffer from rheumatoid arthritis and the pain stops me from sleeping. I now take this at bedtime with a small dose prescribed codeine. Between the painkillers and the "sleep" effect of the Tylenol, I truly can't believe how well I am sleeping! Just be aware that this can really make you fall asleep fast so do be ready for bed. I've spoken to four other people who have various pain problems and they all love this medication too.”

10 / 10
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Sarah087 · Taken for 1 to 2 years August 15, 2018

Tylenol PM (acetaminophen / diphenhydramine) for Insomnia: “Well I take this on & off, especially when we are low on melatonin or I can't simply sleep on melatonin. Some nights I can't sleep with taking it, and I take both. Then it may take me a bit to actually fall asleep but I usually sleep 10/12 hours on it! My daughter told me she couldn't get me up the other day, I told her I remember her saying something to her & she was like yah but you wouldn't get out if bed. ”

5 / 10
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Brooklyntiki · Taken for less than 1 month September 6, 2020

Tylenol PM (acetaminophen / diphenhydramine) for Insomnia: “I am delirious after taking Tylenol PM. Super hot, mind racing in a tortured/exhausted state. Have not stopped sweating can't get comfortable. Amplified exhaustion. Not bad enough for urgent care and too messed up to operate a car.”

1 / 10
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Shaydrum February 10, 2015

Tylenol PM (acetaminophen / diphenhydramine) for Pain: “I was very surprised when I took this medicine. I took it at 9pm and by 9:30 I was in bed sleep. It a high power pill and I rested all night. It a good pill besides the fact that I woke up the next morning and barely could get up and get dressed for work because I was still sleepy for the pill. It finally wore off at about 10am. It helped me a lot. I was told by a friend to take it for pain and I'm glad I got it.”

9 / 10
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Auntj · Taken for less than 1 month January 5, 2017

Tylenol PM (acetaminophen / diphenhydramine) for Insomnia: “I will never take this again. Woke with such a dry mouth I could barely swallow, and a need to use my inhaler. This is NOT a usual thing for me. Reading today, I see that anyone with asthma etc should not use this. I would echo that. I did sleep but still feel unwell and glad I only took TWO.”

1 / 10
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Anonymous March 15, 2012

Tylenol PM (acetaminophen / diphenhydramine) for Insomnia: “I really like this pill besides the fact that I sleep all day. I take the pill every few days at about 12, when I'm not tired and 15 minutes later I become drowsy. About 30 minutes after that, I'm asleep. but I tend to sleep really late. I don't hear my alarms and I can't get myself out of bed. If you do take this I would consider taking it earlier than you normally would. Other then that this pill is the best I have found and works great just like it says.”

9 / 10
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Helene · Taken for 6 months to 1 year August 15, 2021

Tylenol PM (acetaminophen / diphenhydramine) for Pain: “Initially started taking Tylenol PM for ongoing knee & foot pain (I’m a dancer) 6 months ago. Very quickly became a nightly ritual to take one (occasionally 2) and fall asleep within 20 mins and stay asleep for 8+ hrs. The downside - blurred vision (especially in the morning), troubling memory loss (my kids were growing concerned about me not remembering conversations), anxiety and depression (bursting into tears frequently and for no reason). I went ‘cold turkey’ 6 days ago and am already starting to feel better after a couple of sleepless nights. I will NEVER touch this stuff again. It’s easy to see how this drug has been linked to dementia. Please don’t be tempted to use it.”

1 / 10
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Lexi · Taken for less than 1 month June 27, 2020

Tylenol PM (acetaminophen / diphenhydramine) for Headache: “I hate this stuff. I took it at around 10:30pm and it did not help me sleep at all. I have been tossing and turning the whole night and having the most stressful, fast dreams. I woke up completely soaked in sweat even. I also am now awake at 5am (at least the third time I’ve woken up throughout the night) and my nose and throat are drier than the Sahara desert. I also have a heinous headache. I cannot wait until this stuff wears off so I don’t have to feel so dry and uncomfortable anymore.”

1 / 10
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dogsgrandma · Taken for 1 to 6 months July 26, 2012

Tylenol PM (acetaminophen / diphenhydramine) for Insomnia: “This medicine works well for me as a sleep agent and also reduces the itching from mosquito bites. However, I have to be careful when I take it because it seems to last for a couple of days. The "withdrawal" from it the next day includes increased pain.”

10 / 10
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lfsilva October 1, 2009

Tylenol PM (acetaminophen / diphenhydramine) for Headache: “This worked for a while then I started getting rebound headaches. I was waking up to excruciating headaches in the mornings after taking these at night after a period of time. They can increase with intensity over time. If you find this happening to you. You need to get off of them. They are rebound headaches.”

1 / 10
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tazen · Taken for 10 years or more December 19, 2012

Percogesic Original Strength (acetaminophen / diphenhydramine) for Pain: “I was told about this medicine about 10 years ago. At the time I could only find the original strength, and quickly found out that I could not take during the day because it knocks me out and I will be sleeping. It is the only medicine that will take away the pain I am having. I had knee surgery twice in a year and the prescription pain medicine I had took away some pain, but with the Percogesic, the rest of the pain went away and I got to sleep. I tried the maximum strength last year for the first time and discovered that it didn't make me sleep. ...actually hyped me up. I discovered it was different than the original strength by having an antihistamine in which I am sensitive too. So now I can take during the day. its the best!”

10 / 10
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imjustme · Taken for 1 to 2 years April 16, 2013

Acetaminophen PM Extra Strength (acetaminophen / diphenhydramine) for Insomnia: “I have body aches. I'm only 21 and falling apart and I have a real hard time getting to sleep, so I take one or two of these at night depending on my tiredness or achiness, and about 30 minutes to an hour I'm pretty much asleep and almost always stay asleep for 7-9 hours. I normally wake up with no achiness and feeling like I got a pretty decent nights rest. ”

9 / 10
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Anonymous August 22, 2008

Percogesic Original Strength (acetaminophen / diphenhydramine) for Headache: “I remember back when you could only get Percogesic by prescription from a doctor. Nowadays when a prescription is approved to be sold over the counter, the strength of the medication is greatly reduced, which makes it much less effective. I suffer from migraine headaches on a regular basis and am a devoted user of Percogesic, as I have found it alleviates the pain much faster than a lot of the expensive prescription medications I have tried. The only problem is that Percogesic is getting more difficult to find in the stores, so I make sure to stock up whenever I find it!”

10 / 10
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Anonymous November 11, 2008

Percogesic Original Strength (acetaminophen / diphenhydramine) for Pain: “I had a very painful tooth abscess that was not relieved with the popular OTC medicines. A pharmacy technician recommended Percogesic and I felt relief within 30 minutes. Pain relief lasted longer as well so I had to take it less often. The only negative was a minor side effect: dry mouth.”

9 / 10
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Anonymous March 22, 2009

Tylenol PM (acetaminophen / diphenhydramine) for Headache: “I ocasionally use Tylenol rapid release during the day and recently developed cold and flu, so I decided to try Tylenol PM at night for better sleep. Make sure to read the drug interactions first, as I spent two restless nights with nervousness. Many of my friends take this product, so I'll pass it on to them, but if you are on other medication, check the list of side effects.”

1 / 10
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Whitewhisp March 19, 2008

Percogesic Original Strength (acetaminophen / diphenhydramine) for Headache: “I get severe headaches and occasional migraines. Percogesic seems to be the ONLY thing that helps with the pain. I've tried prescription medications for treating migraines, including imitrex, and others. Nothing seemed to help as much as the percogesic, another good thing is that I don't experience any terrible side effects like I have with migraine medictions. I'd highly recommend this. I also take a few times per year (at most) to ease my cramps during my period when the pain is crippling.”

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Pained Zee · Taken for 10 years or more October 10, 2017

Percogesic Original Strength (acetaminophen / diphenhydramine) for Headache: “In my earlier years I had severe migraines. I found that percogesic was very effective in lessening the severity of these. I am 78 now and in 4th stage kidney failure so I am very limited in what OTC products I can safely take. I take a prescription pain med regularly for pain from a bad knee replacement plus 2 hip replacement and severe arthiritis. I take percogesic for headaches since my pain meds do not help them while percogesic will usually stop them. I am very pleased that percogesic still does the job for me.”

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fleajo September 20, 2013

Excedrin PM (acetaminophen / diphenhydramine) for Insomnia: “I love these. When I feel like I will have trouble sleeping, I take 1 pill. That usually works. If it doesn't I take another one. No side effects except sometimes my dreams are better. No hangover. My sister can not take them, they make her groggy.”

8 / 10
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Beba52 August 30, 2013

Percogesic Original Strength (acetaminophen / diphenhydramine) for Headache: “They also have the extra strength Percogesic. I LOVE it. I keep a bottle in my purse all the time. My dr is afraid to write a prescription for anything stronger than a Tylenol, so I have to depend on the Percogesic for my very frequent headaches!”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.