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Acetaminophen / diphenhydramine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acetaminophen / diphenhydramine Trazodone Ambien
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acetaminophen / diphenhydramine Trazodone Ambien (zolpidem)
Over-the-counter

Prescribed for Insomnia, Pain, Headache. acetaminophen / diphenhydramine may also be used for purposes not listed in this medication guide.

Prescription only

Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Only generic forms are available which makes it a lot cheaper than some other... View more

Prescription only

Ambien induces sleep; however, Ambien CR, in particular, may impair physical and mental capabilities the next day. Ambien has also been associated with complex or dangerous sleep-related behaviors... View more

More about Acetaminophen / diphenhydramine More about Trazodone More about Ambien (zolpidem)
Ratings & Reviews

Acetaminophen / diphenhydramine has an average rating of 7.0 out of 10 from a total of 69 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 26% reported a negative effect.

Trazodone has an average rating of 6.3 out of 10 from a total of 1409 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 31% reported a negative effect.

Ambien has an average rating of 7.1 out of 10 from a total of 558 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect.

View all 69 reviews

View all 1409 reviews

View all 558 reviews

Drug Class
Side Effects

See also: acetaminophen / diphenhydramine side effects in more detail.

See also: trazodone side effects in more detail.

See also: Ambien side effects in more detail.
Generic Availability

Lower cost generic

Lower cost generic

Lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 50 tablet
Dosage 500 mg-25 mg
Per Unit* $0.23 - $0.25
Cost* $11.53 - $12.51

View all acetaminophen / diphenhydramine prices

Quantity 100 each
Dosage 50 mg
Per Unit* $0.22 - $0.23
Cost* $22.09 - $22.76

View all trazodone prices

Quantity 100 tablet
Dosage 10 mg
Per Unit* $22.72
Cost* $2,271.99

View all Ambien prices

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Dosage Forms Available
  • Oral tablet
  • Oral tablet
  • Oral tablet
Brand Names
Acetadryl, Acetaminophen PM Extra Strength, Anacin PM Aspirin Free, Bayer Select Max Strength Night Time Pain, ConRx PM, Counteract PM Extra Strength, Excedrin PM, Genapap PM, Headache Formula PM, Headache Relief PM, Legatrin PM, Mapap PM, Midol PM, Night Time Pain, Non-Aspirin PM Extra Strength, Pain Reliever PM, Percogesic Extra Strength, Percogesic Original Strength, Pharbetol PM, Robitussin Honey Severe Cough, Flu + Sore Throat CF Max Nighttime, Tylenol PM, Tylenol Sore Throat Nighttime, Unisom PM Pain, Wal-Nadol PM Extra Strength View more

N/A

 Other zolpidem brands include: Ambien CR, Edluar, Zolpimist
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

9.3 hours

7.5 hours

2.6 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
4
Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
Pregnancy Category
N
Category N Not classified

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 530 drugs are known to interact with acetaminophen / diphenhydramine:

  • 22 major drug interactions (112 brand and generic names)
  • 494 moderate drug interactions (1868 brand and generic names)
  • 14 minor drug interactions (54 brand and generic names)

A total of 652 drugs are known to interact with trazodone:

  • 137 major drug interactions (498 brand and generic names)
  • 500 moderate drug interactions (1926 brand and generic names)
  • 15 minor drug interactions (70 brand and generic names)

A total of 473 drugs are known to interact with Ambien:

  • 29 major drug interactions (154 brand and generic names)
  • 441 moderate drug interactions (1649 brand and generic names)
  • 3 minor drug interactions (6 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Ask your doctor before using acetaminophen together with alcohol. This can cause serious side... View more
  • Alcohol can increase the nervous system side effects of traZODone such as dizziness, drowsiness... View more
  • You should avoid the use of alcohol while being treated with zolpidem. Alcohol can increase the... View more
Disease Interactions
First Approval Date

N/A

December 24, 1981

December 16, 1992
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources

N/A
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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