Skip to Content

User Reviews for Doxepin

Also known as: Adapin, Silenor, Sinequan

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Filter by:
Condition Avg. Ratings Reviews Compare
Major Depressive Disorder
10
   
2 reviews 46 medications
Irritable Bowel Syndrome
7.8
   
5 reviews 142 medications
Urticaria
7.2
   
13 reviews 189 medications
Anxiety
7.1
   
18 reviews 56 medications
Depression
6.9
   
16 reviews 80 medications
Insomnia
6.5
   
186 reviews 108 medications
Reflex Sympathetic Dystrophy Syndrome
3.0
   
1 review 2 medications
Not Listed / Other
8.2
   
8 reviews
Summary of Doxepin reviews 6.7 249 reviews

Reviews for Doxepin

Sort by:

For Insomnia: "I've tried many different drugs that supposedly cure insomnia: melatonin, ambien, lunesta, sonata, rozerem, belsomra, klonopin, various drugs for Parkinson's that have sleepiness side effects, trazodone, elavil, ... the list goes on and on. The only drug that has helped has been doxepin. Like the other drugs I took before, my body has gotten used to lower doses and I've had to increase my dose over time to get the same sleepiness effects but it hasn't caused the same horrendous withdrawal symptoms as some of the other drugs when I've lowered the dose. The downside? WEIGHT GAIN, drowsiness to the point of lethargy during the daytime, and a distended middle. Not fun but then I haven't found a better alternative ..."

   
5.0

Drowsy and distended (taken for 2 to 5 years) April 8, 2018

0 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Insomnia: "I've waited a long time to post this review because I really wanted to like this drug and given a fair trial, but I've been on various doses ranging from 3 mg to 50 mg over the last three years, and I have to say that I don't like the drug at all. I've been using it for insomnia and sometimes it works well and other times it doesn't work at all. And every time I reach a certain dose that I think is working, after a few weeks or months, I have to raise the dose again. My main complaint about this drug is the side effects. Generally speaking, it has helped to put me to sleep but at a great price. It makes me dopey, hungover, feel like sleeping all day long; has given me mental confusion, blurred vision, and even on lower doses like 10 mg or 25, it makes me more depressed because it makes me feel low, tired, doped up. I'm trying to get off it. I would recommend it to other people for short term use."

   
6.0

smackdown February 27, 2018

3 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Silenor (doxepin) for Insomnia: "As long as I wait 3.5 hours after dinner with no snacks I sleep like a baby on Silenor and feel great the next day."

   
10

Bubbles (taken for less than 1 month) February 22, 2018

1 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Urticaria: "It does nothing let alone make me groggy. It's a waste of money. You can take 150mg and still does nothing. I want my money back."

   
1.0

Asshole (taken for 1 to 6 months) February 12, 2018

0 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Silenor (doxepin) for Insomnia: "For me, this stuff just does nothing, absolutely nothing!"

   
3.0

Dave402381 February 7, 2018

1 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Insomnia: "I took this med for my insomnia and all it did was make my head ring for two days! and the next day I was so tired and out of sort! It does not work for sleep! I paid for nothing!!!!!! Very dissatisfied."

   
1.0

Anonymous January 26, 2018

3 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Insomnia: "Doxepin 10 mg did not work at all for sleep. Tried it several times and never again. It is almost 1 am and I am still awake!!! It is worse than taking nothing at all! Useless for me. I will have to go dig out some ambien now or I will be awake all night Very dissatisfied!!"

   
1.0

Anna kata January 21, 2018

4 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Urticaria: "Doxepin is amazing for hives. While waiting for Xolair to work for my urticaria I was desperate to find some relief of the intense itching every single day and Benadryl could not keep up with it. I started twice a day usually 3 pills (25mg) and could go up or down as needed as well as other antihistamines. After 6 months on it, I only take 1 at night and am going to switch to (10mg) Doxepin. I would definitely recommend this drug for urticaria. Side effects were not nice in the beginning like nausea and extreme tired but got used to it. Also have gained weight but is getting better on lower doses."

   
9.0

Emj79 (taken for 6 months to 1 year) January 11, 2018

1 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Urticaria: "I was perscribed Doxepin for relief of an itchy skin condition. I suppose you could say it temporary relieved the itch because I was completely unconscious for the next 12 hours and unaware of everything, itchy and otherwise. I was groggy and zombie-ish for the next 12 hours, and occasionally had to reach for walls or furniture to keep from falling over. I feel like I lost a day of my life. Verdict: NOPE."

Adelthea (taken for less than 1 month) January 10, 2018

0 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Anxiety: "Started on Doxepin 100mg January 2017 due to debilitating GAD and panic attacks. I was miserable. Ten minutes after waking up, the panic attacks would start. I quit going out in public as much as possible. At night, I couldn't shut my mind off, which exasperated my insomnia. I was taking more Xanax than prescribed to try to get through the day. I specifically asked my psych for this based on reviews. Helped right away with sleep (with no next day grogginess for me), and after about a week, started putting the brakes on my anxiety. Slowly noticed I was getting parts of my life back. It served its purpose and pretty darn well, but in ten months I gained 30lbs and kept gaining. Due to the ongoing weight gain I switched to gabapentin instead."

   
7.0

BBP007 (taken for 6 months to 1 year) December 2, 2017

3 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Depression: "I took this as prescribed safe to take from a sleep doctor, but my depression lifted, I'm a new person!"

   
10

Jujupop29 December 1, 2017

1 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Silenor (doxepin) for Insomnia: "I take this around 10 at night and still wake up 3am in the morning. To expensive for me."

   
3.0

dkp51 November 13, 2017

6 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Insomnia: "In my never ending quest for migraine prevention, my doctor decided to try doxepin to try to take out the migraines, the anxiety, and the insomnia all at once, figuring it "couldn't hurt." Well. It hurt. No effect on migraines, sleep, or anxiety. None at all. It did, though, drop my blood pressure so low I couldn't walk for long, needed to lean on walls to stay upright, couldn't carry a cohesive conversation because I was too foggy to remember what I'd already said - in short, it did no good and left me unable to function at work, safely drive, make it up the steps to my bedroom, etc. Pulse also became erratic. And? I was only on half the child's starting dose. It was bad enough that I stopped it and then told the doctor."

   
1.0

Squirrelyone (taken for less than 1 month) November 6, 2017

4 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Anxiety: "Had to stop it because of the nightmares it produced. Tried dosages between 6-100mg. No matter what, I had terrifying nightmares when I went to sleep."

   
3.0

nick-name (taken for 1 to 6 months) October 21, 2017

3 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Anxiety: "I have suffered with severe anxiety and panic attacks, which manifested itself into not sleeping. I literally stopped sleeping for several days. Ended up in the ER a couple times and at the doctors all that week and finally had to be admitted to a mental health facility because nothing they were giving me was working. I literally thought I was going to die. After 9 days they finally found something that helped me sleep. It was a combination of Doxepin 100mg, Xanax, Tramadol (which soon switched to Benadryl) and Ambien. These drugs gave me my life back and slowly restored my sleep cycle. After a year or so I was weaned off the Ambien and then the Benadryl, so now I just take the Xanax & Doxepin (now lowered to 50mg). Amazing."

   
10

righton2 October 10, 2017

3 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Anxiety: "Honestly, a very good drug for anxiety and depression symptoms. The worse side effect is the weight gain. But in the end, for me personally, I would prefer relief from anxiety."

   
9.0

stayinalive (taken for 2 to 5 years) September 28, 2017

4 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Anxiety: "Hi milemile I have been on doxepin many years for panic attacks before this medicine I stopped going out anywhere. You will be tired for a bit of time but it goes away . It stopped all panic attacks. Never had one panic attack for 10 years on this medicine. But I stopped to try other meds for higher mood. But when I stopped doxepin the panic attacks returned so 10 years without panic attack on doxepin is a good thing!"

   
9.0

No panic September 24, 2017

4 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Silenor (doxepin) for Insomnia: "Use to take Ambien but side effect were starting to drive me nuts. Nightmares, almost depressed when waking up. Silenor really saved me. Incredible feeling, like normal sleep. No side effects at all in my case. I'm surprised it's not more promoted."

   
10

M. H. (taken for 6 months to 1 year) September 17, 2017

30 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Anxiety: "Hello, I was prescribed Doxepin for anxiety, panic attacks and depression. I took it last night and slept great but this am I could NOT open my eyes and all day I have been beyond drowsy even spaced out and exhausted. I took 10 mg at bedtime last night. I am going to try taking it at dinner time tonight around 7pm. I am glad I slept great but I cannot function on this exhaustion. Please tell me these side effects go away. Also could one pill do all this. Last night was first time I tried this:-(. Thanks"

milemile (taken for less than 1 month) September 1, 2017

7 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Depression: "This stuff garbage woke up hyper and shortness breath I thought this med suppose to make me sleep ??? Just horrible med!!! All these side effects listed too be carefull!! I'm better off with my anxiety sleeplessness"

   
1.0

manfreakca (taken for less than 1 month) August 3, 2017

7 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Silenor (doxepin) for Insomnia: "changed my life - I now stay asleep 7-8 hours and zero side effects"

   
10

Little Willie (taken for 2 to 5 years) August 1, 2017

28 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Insomnia: "Doxepin does not help me fall asleep. It does help me stay asleep. I suffer from anxiety and depression and that's why I can't sleep. To those people who have experienced extreme tiredness the next day this also happens to me even though I take it as the manufacturer suggest for Sleep maintenance which is to take on a completely empty stomach 3 hours after a meal. Otherwise the onset is delayed even further. By several hours leading to next day sedation even more. Even when taking the proper way it has a 15-hour half-life which can still leave you tired and groggy the next day which I also experience even taking it correctly."

   
4.0

Proper med user (taken for 1 to 6 months) July 28, 2017

19 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Silenor (doxepin) for Insomnia: "Caused restless leg syndrome; unable to fall asleep. Miserable nights due to lack of sleep."

   
1.0

Sungold1950 July 28, 2017

13 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Insomnia: "I have had insomnia since I was a teen, and I am turning 50 next mo. My doctors had tried me on natural aids, and almost every sleeping pill in the book. The sleeping pills would put me to sleep but I could not stay asleep.....most nights I would get up about 1:00am for a bathroom trip and would be up for a few hrs. Some nights I would get up to go to the restroom and stay up for the rest of the night. Then, my doctor prescribed doxepin. Thank goodness! I go to sleep, and even if I get up to go to the restroom during the night, I am able to go back to bed and SLEEP! I use the liquid and take 10mgs each night and don't have any hangover the next day. The scrip costs me less than $5 for a 90-day supply. My ins co would not cover Silenor."

   
10

Dolly1367 July 19, 2017

22 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Insomnia: "After the doctor tried other pills on me for depression, anxiety, PTSD and insomnia with horrible nightmares he decided to try 100mg of Doxepin in the evenings saying it was an older pill not used as much anymore. My body is resistant to medications and requires high doses of meds in order to notice any affects. Its hard for them to knock me out for surgery and keep me knocked out. But so (it's only been about a week) far the Doxepin has been working great at making me sleep. It takes several hours to knock me out but when it does I'm out without waking up every 10 minutes in misery with nightmares and physical pain. I tend to be groggy in the mornings though. I hope my body doesn't grow resistant to it."

Finally Sleeping (taken for less than 1 month) June 21, 2017

23 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Page 1 2 3 4 5 6 7 8 9 10 Next

Learn more about

Symptoms and treatments

Mayo Clinic Reference

Hide