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Medications for Irritable Bowel Syndrome

Other names: IBS; Spastic colon

About Irritable Bowel Syndrome:  A functional bowel disorder characterised by recurrent crampy abdominal pain and diarrhea. Invasive gastrointestinal diagnostics are often unrevealing.

Drugs Used to Treat Irritable Bowel Syndrome

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
dicyclomine B N X 169 reviews
7.0

Generic name: dicyclomine systemic

Brand name:  Bentyl

Drug class: anticholinergics/antispasmodics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Bentyl B N X 87 reviews
7.0

Generic name: dicyclomine systemic

Drug class: anticholinergics/antispasmodics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

hyoscyamine C N X 67 reviews
8.0

Generic name: hyoscyamine systemic

Brand names:  Levsin, Levsin SL, Levbid, Anaspaz, HyoMax, Symax Duotab, HyoMax SL, Hyosyne, HyoMax SR, NuLev, A-Spaz, Colidrops, Ed-Spaz, HyoMax DT, HyoMax FT, Oscimin, Symax FasTab, Symax SL, Symax SR …show all

Drug class: anticholinergics/antispasmodics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Amitiza C N 55 reviews
6.0

Generic name: lubiprostone systemic

Drug class: chloride channel activators

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Donnatal C N X 21 reviews
9.0

Generic name: atropine / hyoscyamine / phenobarbital / scopolamine systemic

Drug class: anticholinergics/antispasmodics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Librax D N X 41 reviews
9.0

Generic name: chlordiazepoxide / clidinium systemic

Drug class: anticholinergics/antispasmodics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Linzess C N 160 reviews
6.0

Generic name: linaclotide systemic

Drug class: guanylate cyclase-C agonists

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

amitriptyline Off Label C N X 77 reviews
8.0

Generic name: amitriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Levsin C N X 12 reviews
6.0

Generic name: hyoscyamine systemic

Drug class: anticholinergics/antispasmodics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

chlordiazepoxide / clidinium D N X 50 reviews
8.0

Generic name: chlordiazepoxide / clidinium systemic

Brand name:  Librax

Drug class: anticholinergics/antispasmodics

For consumers: dosage, interactions,

For professionals: Prescribing Information

Levsin SL C N X 5 reviews
9.0

Generic name: hyoscyamine systemic

Drug class: anticholinergics/antispasmodics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Lotronex B N 18 reviews
9.0

Generic name: alosetron systemic

Drug class: serotoninergic neuroenteric modulators

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

atropine / hyoscyamine / phenobarbital / scopolamine C N X 26 reviews
9.0

Generic name: atropine / hyoscyamine / phenobarbital / scopolamine systemic

Brand names:  Donnatal, Antispasmodic, Donnatal Extentabs, Alkabel-SR, B-Donna Tablets, Bellatal, D-Tal, Hyosophen, Me-PB-Hyos, PB-Hyos, Phenohytro, Quadrapax, RE-PB Hyos Elixir, Se-Donna PB HYOS, Servira, Vitetal …show all

Drug class: anticholinergics/antispasmodics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, Prescribing Information

cholestyramine Off Label C N 54 reviews
9.0

Generic name: cholestyramine systemic

Drug class: bile acid sequestrants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Levbid C N X Add review
9.0

Generic name: hyoscyamine systemic

Drug class: anticholinergics/antispasmodics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Anaspaz C N X Add review Rate

Generic name: hyoscyamine systemic

Drug class: anticholinergics/antispasmodics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Antispasmodic C N X Add review Rate

Generic name: atropine / hyoscyamine / phenobarbital / scopolamine systemic

Drug class: anticholinergics/antispasmodics

For consumers: dosage, interactions, side effects

escitalopram Off Label C N X 10 reviews
8.0

Generic name: escitalopram systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Konsyl N N 2 reviews
10

Generic name: psyllium systemic

Drug class: laxatives

For consumers: dosage, interactions, side effects

Xifaxan C N 34 reviews
5.0

Generic name: rifaximin systemic

Drug class: miscellaneous antibiotics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Metamucil N N 5 reviews
6.0

Generic name: psyllium systemic

Drug class: laxatives

For consumers: dosage, interactions, side effects

nortriptyline Off Label N N X 33 reviews
9.0

Generic name: nortriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

psyllium N N 7 reviews
6.0

Generic name: psyllium systemic

Brand names:  Konsyl, Metamucil, Hydrocil, Laxmar, Natural Fiber Therapy, Reguloid …show all

Drug class: laxatives

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts

venlafaxine Off Label C N X 13 reviews
8.0

Generic name: venlafaxine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

HyoMax C N X 1 review
8.0

Generic name: hyoscyamine systemic

Drug class: anticholinergics/antispasmodics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

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Alternative treatments for Irritable Bowel Syndrome

The following products are considered to be alternative treatments or natural remedies for Irritable Bowel Syndrome. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Irritable Bowel Syndrome.

Learn more about Irritable Bowel Syndrome

IBM Watson Micromedex

Symptom checker

Symptoms and treatments

Drugs.com Health Center

Mayo Clinic Reference

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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