Dicyclomine Side Effects
For the Consumer
Applies to dicyclomine: oral capsules and tablets, oral solution, parenteral injection
Side effects include:
Most adverse effects are manifestations of pharmacologic effects at muscarinic-cholinergic receptors and usually are reversible when therapy is discontinued.
Severity and frequency of adverse effects are dose related and individual intolerance varies greatly; although adverse effects occasionally may be obviated by a reduction in dosage, this also will likely eliminate potential therapeutic effects. If dosage of ≥80 mg daily cannnot be achieved because of intolerance, discontinue dicyclomine.
Dry mouth, dizziness, blurred vision, nausea, light-headedness (especially with the injectable form), drowsiness, weakness, nervousness.
For Healthcare Professionals
Applies to dicyclomine: compounding powder, intramuscular solution, oral capsule, oral syrup, oral tablet
-The most serious adverse reactions include cardiovascular and central nervous system symptoms.
-The most common adverse reactions are dizziness, dry mouth, vision blurred, nausea, somnolence, asthenia and nervousness, fever, tachycardia, agitation, and dry skin/mucous membranes.[Ref]
Very common (10% or more): Dry mouth (33%), nausea (14%)
Rare (less than 0.1%): Constipation, anorexia
Frequency not reported: Thirst, delayed gastric emptying time, reduced gastric acid secretion, gastroesophageal reflux
Postmarketing reports: Abdominal distension, abdominal pain, dyspepsia, constipation, dry mouth, nausea, vomiting[Ref]
Very common (10% or more): Dizziness (40%)
Common (1% to 10%): Somnolence, nervousness
Rare (less than 0.1%): Sedation, headache
Postmarketing reports: Dizziness, headache, somnolence, syncope[Ref]
Very common (10% or more): Blurred vision (27%)
Frequency not reported: Follicular conjunctivitis, all muscarinic antagonists can precipitate glaucoma
Postmarketing reports: Cycloplegia, mydriasis, blurred vision[Ref]
Common (1% to 10%): Asthenia
Frequency not reported: Fatigue
Postmarketing reports: Malaise, fatigue[Ref]
Rare (less than 0.1%): Rash
Postmarketing reports: Allergic dermatitis, erythema, rash[Ref]
Rare (less than 0.1%): Dysuria[Ref]
Frequency not reported: Urinary retention, impotence in male patients
Postmarketing reports: Suppressed lactation[Ref]
Postmarketing reports: Palpitations, tachyarrhythmias, thrombosis, thrombophlebitis[Ref]
Postmarketing reports: Face edema, angioedema, anaphylactic shock[Ref]
Postmarketing reports: Local pain, edema, skin color change, reflex sympathetic dystrophy syndrome (caused by inadvertent IV injection)[Ref]
Postmarketing reports: Delirium or symptoms of delirium such as amnesia (or transient global amnesia), nervousness, agitation, confusional state, delusion, disorientation, hallucination (including visual hallucination), and mania, mood (altered and pseudodementia).[Ref]
Postmarketing reports: Dyspnea, nasal congestion[Ref]
1. Kagan G, Huddlestone L, Wolstencroft P "Comparison of dicyclomine with antacid and without antacid in dyspepsia." J Int Med Res 12 (1984): 174-8
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. "Product Information. Bentyl (dicyclomine)." Aventis Pharmaceuticals, Kansas City, MO.
Not all side effects for dicyclomine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about dicyclomine
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- Drug class: anticholinergics/antispasmodics
Other brands: Bentyl
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