Dicyclomine Side Effects
For the Consumer
Applies to dicyclomine: oral capsules and tablets, oral solution, parenteral injection
Side effects include:
Most adverse effects are manifestations of pharmacologic effects at muscarinic-cholinergic receptors and usually are reversible when therapy is discontinued.
Severity and frequency of adverse effects are dose related and individual intolerance varies greatly; although adverse effects occasionally may be obviated by a reduction in dosage, this also will likely eliminate potential therapeutic effects. If dosage of ≥80 mg daily cannnot be achieved because of intolerance, discontinue dicyclomine.
For Healthcare Professionals
Applies to dicyclomine: compounding powder, intramuscular solution, oral capsule, oral syrup, oral tablet
-The most serious adverse reactions include cardiovascular and central nervous system symptoms.
-The most common adverse reactions are dizziness, dry mouth, vision blurred, nausea, somnolence, asthenia and nervousness, fever, tachycardia, agitation, and dry skin/mucous membranes.[Ref]
Very common (10% or more): Dry mouth (33%), nausea (14%)
Rare (less than 0.1%): Constipation, anorexia
Frequency not reported: Thirst, delayed gastric emptying time, reduced gastric acid secretion, gastroesophageal reflux
Postmarketing reports: Abdominal distension, abdominal pain, dyspepsia, constipation, dry mouth, nausea, vomiting[Ref]
Very common (10% or more): Blurred vision (27%)
Frequency not reported: Follicular conjunctivitis, all muscarinic antagonists can precipitate glaucoma
Postmarketing reports: Cycloplegia, mydriasis, blurred vision[Ref]
Common (1% to 10%): Asthenia
Frequency not reported: Fatigue
Postmarketing reports: Malaise, fatigue[Ref]
Postmarketing reports: Delirium or symptoms of delirium such as amnesia (or transient global amnesia), nervousness, agitation, confusional state, delusion, disorientation, hallucination (including visual hallucination), and mania, mood (altered and pseudodementia).[Ref]
1. Kagan G, Huddlestone L, Wolstencroft P "Comparison of dicyclomine with antacid and without antacid in dyspepsia." J Int Med Res 12 (1984): 174-8
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. "Product Information. Bentyl (dicyclomine)." Aventis Pharmaceuticals, Kansas City, MO.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
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- Drug class: anticholinergics/antispasmodics
- Dicyclomine Capsules
- Dicyclomine Syrup and Oral Solution
- Dicyclomine Tablets
- Dicyclomine Injection
Other brands: Bentyl