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User Reviews for Nortriptyline to treat Irritable Bowel Syndrome

Also known as: Pamelor, Aventyl Hydrochloride

Nortriptyline has an average rating of 8.3 out of 10 from a total of 43 ratings for the treatment of Irritable Bowel Syndrome. 81% of users who reviewed this medication reported a positive effect, while 9% reported a negative effect.

Nortriptyline Rating Summary

8.3/10 average rating

43 ratings from 43 user reviews.

Compare all 76 medications used in the treatment of Irritable Bowel Syndrome.

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Reviews for Nortriptyline

grateful_heart June 10, 2020

“Honestly, this medication saved my life - it is a miracle. I have suffered with IBS for 10 years (am now 20) and it caused me to miss so much school. I started on 10mg of Amitrityptline in Dec 2019 and within a few weeks I had really terrible mental side effects. I became apathetic & had sustained low moods which were uncharacteristic. I switched to 10mg of Nortriptyline after 3 weeks and have been on the same dose since (it is now June 2020). It took exactly 3 weeks for me to start feeling a difference - but then after that, the improvement just got better and better. I now have almost no IBS issues! This medication won't, however, erase your food intolerances. If I go near dairy or fried chips, or have loads of large meals then I might still have a bit of trouble. But I went from having such a limited diet to now being able to eat almost anything, and it has made life so much easier. Alhamdullilah for this miracle drug, I seriously cannot recommend it highly enough :,)”

10 / 10
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Anonymous · Taken for 1 to 6 months June 12, 2019

“After years of suffering with IBS-(D), I ended up seeing a brand new doctor at the Polyclinic. He started off treatment by eliminating all of the scary stuff- I had an endoscopy, colonoscopy, gastric emptying study, blood work, etc. When all results came back normal, he decided to treat the IBS symptoms with Nortriptyline (25 mg per night) and the low fodmap diet. I am thrilled to say that my symptoms have finally subsided, at least enough to where I can live my life and eat comfortably. Although I wouldn’t say I’m completely symptom free, I feel significantly better. I’m not sure if it was this medicine or the low fodmap diet that worked best, however I will continue to do both and slowly add foods back in. Definitely try this out if it is recommended for you! This is coming from someone who suffered for 6+ years and has tried every diet, supplement, and medication known to man.”

8 / 10
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Xj · Taken for 1 to 6 months November 12, 2020

“Nortriptyline changed my life from the drama of IBS. I went from running to the toilet all the time and cancelling days to maybe 4x/month diarrhea, and I actually feel hungry and not scared to eat!! Literally in a new person. So glad my NP prescribed it.”

9 / 10
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Mave · Taken for 6 months to 1 year January 4, 2021

“I was put on one 10mg Nortriptyline to see if it would help with severe bowel pain, it did seem to help a bit in that the pain stopped lasting the whole day, after a few weeks it was increased to 15grams and then to two 10 mg tablets making it 20mg. Unfortunately it made me very constipated and I had the worst headaches I've ever had in my life including Migraine that I suffered from for a couple of years. I have only been taking this drug for about 8 months and I was really hoping it would help the severe bowel pain that I have daily. I have stopped taking the 20 mg and have gone back trying just one tablet of 10 mg which I really hope will help. Another thing the drug causes is the most horrible taste in my mouth when I wake up in the morning that is there every morning and is difficult to get rid off I had big hopes for this drug. I do intend to try taking just 1 tablet of 10mg to see if I get any relief taking that dose”

2 / 10
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luri February 23, 2013

“I have had Irritable Bowel Syndrome for 30 years and it has gradually gotten so bad that I told my doctor that I could no longer have a normal life and I hated what irritable bowel syndrome was doing to me. He prescribed 10mg of nortriptyline and I highly doubted it would help. I was already on another antidepressant. However, it helped so much...it is a God send! I can now enjoy life again. I can eat! I am not worrying about how I am going to get through the day with stomach pain. I can make plans to do things. I can enjoy my family and work again.”

10 / 10
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9lives · Taken for 1 to 6 months September 12, 2018

“I was having bad pain and discomfort in my abdominal area and testicle. This went on for 5 months. I saw several doctors and had an MRI, ultrasound, blood tests you name it I had it. Finally, after doing my own research I asked my doctor to put me on 10mg . After about 3 days I started to notice a difference and after a week about 95% of my pain was gone. This med worked wonders for me and saved my life! I went from only being able to eat plain chicken, potatoes and spinach to being able to eat anything I want. I have been on this med for about 2 months now. I do not have any side effects to speak of . Everyone is different and your results may vary. Give it a try but try and stay at 10mg if taking for pain.”

10 / 10
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freedom12356789 July 12, 2017

“One of the first reviews I've written regarding a treatment. My IBS-D got to a point where I was visiting the bathroom about 5-6 times a day. When I wasn't in the bathroom the uneasiness associated with IBS stopped me from focusing on anything I tried to do. All I wanted to do was stay in bed and distract myself with movies and TV shows. I spent lots of time researching online and trying various treatments including elimination diets, supplements, various exercises etc.. My GP recommended I try Nortriptyline at nights starting at 10mg dosage and said that it'd take around a month to kick in. After about 3 weeks I switched to taking it in the morning and it's been working wonders every since. Pretty much IBS free and have my life back.”

10 / 10
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Frequently asked questions

JZ620 March 7, 2013

“This medication has been a life saver. I am a 23 year old female and was diagnosed with Irritable Bowel Syndrome 10 years ago. It wasn't until 2 years ago that my primary care doctor suggested this medication after finding success with another patient. Only 10 mg a day at bedtime and I am IBS symptom free. I used to have 5 bowel motions a day and now I am very regular. My life is so different now that I am on this medication. When I started the medication I had extreme dry mouth that went away after a couple of months and now I sometimes become constipated (which is something I've never had in my life).”

10 / 10
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Anonymous June 24, 2014

“I suffered with Irritable Bowel Syndrome for over 30 years beginning in my 30's after a severe gastrointestinal infection. I controlled it with OTC meds like Pepto-Bismol and Imodium. The condition worsened until I could no longer count on having a symptom free day and my diet was severely limited. My doctor recommended Nortriptyline and the lowest dose of 10 mg immediately worked. I now can eat a diet that includes fruits and vegetables I has been unable to eat for years. I did have one troubling side effect at first -rapid heart rate. I was taking a low dosage of a beta blocker for this condition prior to taking Nortriptyline. My doctor recommended increasing my beta blocked dosage, and the palpitations have discontinued. I am healthy and very active.”

10 / 10
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Mousse · Taken for 1 to 6 months December 21, 2017

“I HAD UNRELENTING DIARRHEA AND COULD NOT LEAVE THE HOUSE WITHOUT TAKING IMMODIUM. My doctor prescribed nortriptyline. I filled the prescription but did not take it because well I almost thought it was foolish. I was not depressed... But then I thought what the heck. I started the 10 mg every night. In 3 days the only side affect was no more running to the bathroom. OMG for me it is a miracle. I do have vivid dreams but that is ok and Also sleep well and feel great when I wake up.”

9 / 10
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Hypnotic401 · Taken for 1 to 2 years January 6, 2017

“Took about a month to kick in, but once it kicked in it was like night and day! I was in a bad way, bad liver issues which just exacerbated my IBS. I can eat and drink what I want now, my sleeping patterns are better, I'm more relaxed, and just happier! Gastro doc put me on 50mg a day at night. What a relief it is to not have to worry about IBS dominating my life!”

9 / 10
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nortrip fan · Taken for 2 to 5 years November 13, 2016

“I suffered from debilitating IBS and was on the brink of having to leave my job on disability as a result. I also had developed severe anxiety. After over a year and many trips to a gastro, I went to a psychiatrist to treat my IBS induced anxiety who prescribed nortriptyline. It was a life saver. I have been on it for 2 years and am completely symptom free. Truly a miracle drug for me. Only reason for a 9 -- on the two occasions when I forgot to take the medicine I felt very sick. Must be taken EVERY day.”

9 / 10
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gt85 April 2, 2016

“Had stomach pain for years. When I ate, my stomach would hurt for hours. When it finally calmed down, it was time to eat again. Went to a gastroenterologist. Had a colonoscopy, endoscopy and biopsies. Everything looked all right. Was having awful pain one day and called my gastro doctor for an appt. He could not see me for weeks, but I was told his nurse could. I was hesitant, but did go in & see her the next day. She prescribed 10 mg. Pamelor at bedtime (name brand for nortriptyline). She said it was an antidepressant, but had been found to help many issues. After taking for 3 nights, I felt like a new person. When I went back for followup, I hugged my nurse and said, "You gave me back my life."”

10 / 10
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Feelin Good September 8, 2016

“I experienced abdominal pain due to IBS for years. These pains were present no matter what I ate. While these pains were at their peak I could hear gurgling in my stomach area therefore I knew they were gas related. Doctors tried every test known but couldn't find anything wrong. I had nearly given up hope. The only thing that seemed to help at all was activated charcoal. One day a nurse practitioner prescribed me nortriptyline to trial. She told me that it wasn't for IBS but it may help with some of its symptoms. Within a week my pains went away and have been gone now for 2 years. I take one pill every night before bed. I am another who will say that nortriptyline has changed my life.”

10 / 10
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LFuh · Taken for 2 to 5 years October 21, 2016

“This medicine has changed my life. I went a solid 10+ years living in pain and with constant diarrhea. My life revolved around going to the bathroom. I started taking nortryptaline and after a few days the pain subsided. Then, after a few months and increasing to a max dose of 40mg I now have NORMAL bowel movements. This medicine is a miracle. It also prevents my migraines which were occurring up to several times a month. I only experienced side effects of dry mouth, fatigue, and brain fog for the first couple months. I now have no negative effects. Thank you Nortryptaline for giving me a normal life.”

10 / 10
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Miss Tata September 22, 2016

“The medication has changed my life!!! I can finally focus on my goals and I feel great! No more pain, no more bathroom sneak attacks (thank you!!) and no more bloating! For the longest time it looked like I had a belly but it was all bloating! I can see a significant change in the decrease of bloating. The first couple days after taking the medicine at night would result in a little fogginess in the morning and fatigue. Now that my body has gotten used to Nortriptyline, I have much more energy and honestly a whole new outlook on life. I don't even want to think about how I felt every single day before Nortriplyline. I owe my Dr. big time!! :)”

10 / 10
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Texas37 September 24, 2010

“I was diagnosed with irritable bowel syndrome two years ago in August 2008. It's been a long, lousy 2 years. I've been on many different medicines and none of them worked. Finally nortriptyline (25mg) once a day before bed has FINALLY given me relief. It's only been one week since I started this drug but it's been a week where I can actually leave the house and not worry about my IBS (diarrhea) issues. I'm a 37 year old male. Lomotil and Imodium have only worked partially for me. Nortriptyline worked right away (the next day I was issue free - and I'm not exaggerating) I wish my doctor had me try this medicine earlier, although I do understand him wanting me to try other medicines first. HOWEVER, I still take a half Imodium every other day with this medicine.”

8 / 10
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Meme · Taken for 1 to 2 years July 14, 2021

“I'm 34 yrs old and have been suffering with IBS for about 5 yrs now. I started taking 25mg nortriptyline and it had made a huge difference. I never could get any sleep and tossed and turns at night due to the pain. I noticed I started sleeping better and longer and didn't deal with daily pain. However, I had tried to stop this medication in the past and it caused major withdrawals. But it I would recommend this to anyone suffering with IBS. The only side effect for me was drowsiness.”

9 / 10
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Oopsiedaisies · Taken for 6 months to 1 year August 31, 2015

“I have had post-infectious IBS for about 9 months. I couldn't go to work, I couldn't eat, and I had severe abdominal cramping and diarrhea several times a day. I lost about 10lbs (I'm underweight to begin with, so this was troublesome). My gastroenterologist prescribed nortriptyline and Bentyl (Bentyl for intestine cramping, which I was able to stop taking once the nortriptyline kicked in), and I was back to nearly normal within a week. After several months of thinking I was healed, I stopped taking nortriptyline and my symptoms returned almost full-blown within a few days. Now I'm back on it and I feel fine again. I have had no side effects, except a little drowsiness when I take it (though I take it before bed, so it's not a problem)!”

9 / 10
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Annabwelle November 8, 2016

“Well, it's been about 8 months now since being prescribed 10 mg Nortriptyline HCL. I take it once a day before bed. I also take Dicetel 50 mg up to 3 X a day although most days I don't even feel the need to take it. It does help though when I take it. Before meals. I've had IBS for close to 20 years. I was ALWAYS afraid to go out to eat. I'd always make reasons to get out of going out with friends. It literally ran my life I've felt better since the start and wish I've been given this years ago. This has 98% worked for me & I would suggest it to anyone to try it! Good luck”

10 / 10
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Flip · Taken for 1 to 6 months October 28, 2019

“I have had IBS with gut pain for 35 years. Two years ago I became intolerant of wheat and dairy and developed IBS D. I tried Nortriptyline at 10mg which didn't help with the pain or diarrhea. I then moved on to 20mg and have been on it for 2 months with less frequent diarrhea but still with pain. I've just decided to come off it now. The biggest improvement in my IBS symptoms was using probiotic, which I think I will start again.”

1 / 10
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Nica · Taken for 1 to 6 months May 16, 2020

“This drug nortriptyline made me feel nothing. I didn't care about nothing much. It caused my boyfriend left and I didn't care at the time. Giving this drug for people with IBS its crazy. I would never again take anything like that. Before I realised it ruined my love life.”

1 / 10
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Melsayles May 10, 2016

“Started taking nortriptyline for chronic pain and noticed all my IBS with diarrhea symptoms were gone!! Bonus! It was so dibilatating and painful, I was miserable. Constant pain, bloating, cramping. This drug has saved my life! It also treated my chronic fatigue. For most people it makes them tired but for me it was the opposite. So very thankful. Three problems fixed with one medication! However, it has increased my heart rate and worsened my anxiety. And also squashed my sex drive. That sucks! But the benefits out weigh the negative.”

10 / 10
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Mizz Greeneyez October 28, 2017

“I was first put on this med because I suffer with migraines and the doctor wanted to see if it would help with them. Far as my IBS goes I was put on Dicyclomine which wasn't helping me at all. After being on Nortriptyline for my migraines I stared taking noticed that it was helping me with my IBS. I wasn't having the sharp pains anymore and didn't have to worry about staying near a bathroom. Seeing that Nortriptyline wasn't helping me with my migraines the doctor took me off of the meds. I've been off of it for a month and since then my IBS has been in full effect. So my family doctor put me back on them which I will start tonight. Can't wait for it to get back into my system so it will get it back straight”

10 / 10
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Gloryoski May 26, 2015

“I was actually homebound with post infectious IBS. The pain in my upper abdomen wore me down. I couldn't do anything. This lasted from March of 2014 to March of 2015. I thought I was going to die. Finally a doctor at U of M prescribed nortriptyline 10mg at bedtime. It worked within a few days. My pain was gone. I am now working with a dietician and testing foods to see if there is a trigger to my IBS. But I can have a decent life now!”

9 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

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