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Stomach / Heartburn Medications and Alcohol Interactions

Written by L. Anderson, PharmD on Nov 7, 2017.

Cimetidine (Tagamet, Tagamet HB)

  • Cimetidine is an acid blocker used to treat heartburn and gastroesophageal reflux disease (GERD). Talk to your doctor before consuming alcohol while taking cimetidine. Using cimetidine and alcohol together may increase the effects of alcohol, leading to increased drowsiness and dizziness.
  • Cimetidine may inhibit an enzyme needed to break down alcohol (alcohol dehydrogenase), but the clinical significance of this interaction is limited. Chronic alcohol may worsen gastric ulcer disease, as well. Other H2 blockers such as ranitidine (Zantac) or famotidine (Pepcid) have minimal effects on alcohol metabolism.
  • Proton pump inhibitors such as omeprazole (Prilosec OTC, Zegerid OTC) or lansoprazole (Prevacid OTC) are not listed as having drug interactions with alcohol in the product label.

Dicyclomine (Bentyl)

  • Dicyclomine is an anticholinergic and antispasmodic agent used to help with stomach spasms and intestinal problems such as irritable bowel syndrome (IBS). Check with your doctor before combining alcohol and dicyclomine. Alcohol may lead to additive drowsiness or dizziness when combined with dicyclomine. Avoid activities requiring mental alertness such as driving or operating machinery while using dicyclomine.

Eluxadoline (Viberzi)

  • Eluxadoline is used to treat irritable bowel symptoms such as pain and diarrhea in patients without constipation. Avoid excessive alcohol use during treatment with eluxadoline. Drinking more than 3 alcoholic beverages per day while taking eluxadoline may increase the risk of pancreatitis, or inflammation of the pancreas.

Metoclopramide (Metozolv ODT, Reglan)

  • Metoclopramide increases the motility of the upper gastrointestinal tract and may block dopamine receptors. Metoclopramide is an agent used for gastroesophageal reflux disease (GERD), diabetic gastroparesis, and nausea and vomiting linked cancer treatment or after surgery, among other uses. Additive sedative effects can occur when metoclopramide is given with alcohol. Check with your doctor before using alcohol with metoclopramide and use caution when performing activities that require mental alertness, such as driving or operating machinery.

*Note: The lists presented in this article do not include all the medicines that may interact harmfully with alcohol. To more closely examine specific interactions, visit the Drugs.com Interaction Checker and speak with your doctor or pharmacist.

Types of Drug Interactions With Alcohol

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