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Generic Name: eluxadoline (EL ux AD oh leen)
Brand Names: Viberzi

Medically reviewed on June 7, 2017.

What is Viberzi?

Viberzi (eluxadoline) works directly in your intestines to slow the movement of food during digestion. Eluxadoline also makes the nerves in your intestines less sensitive to stimulation.

Viberzi is used to treat irritable bowel syndrome when the main symptom is diarrhea.

Viberzi may also be used for purposes not listed in this medication guide.

Important information

You should not use Viberzi if you have a pancreas disorder, severe liver disease, alcoholism, a blockage in your intestines, a gallbladder disorder, or if your gallbladder has been removed.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Viberzi if you are allergic to eluxadoline, or if you have:

  • severe constipation or a blockage in your intestines;

  • a history of gallbladder obstruction, or if your gallbladder has been removed;

  • digestive problems caused by a muscle valve called the sphincter of Oddi (SFINK-ter of OD-dee);

  • severe liver disease;

  • a pancreas disorder; or

  • a habit of drinking more than 3 alcoholic beverages per day.

To make sure Viberzi is safe for you, tell your doctor if you have:

  • liver disease.

It is not known whether eluxadoline will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether eluxadoline passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Viberzi is not approved for use by anyone younger than 18 years old.

How should I take Viberzi?

Take Viberzi exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Take with food.

Call your doctor if your symptoms do not improve, or if they get worse.

Store at room temperature away from moisture and heat.

Viberzi may be habit-forming. Never share Viberzi with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Viberzi dosing information

Usual Adult Dose for Irritable Bowel Syndrome:

Usual dose: 100 mg orally twice a day

-Dose may be reduced to 75 mg orally twice a day for patients unable to tolerate usual dose
-As of February 2017, the US FDA has recommended patients without a gallbladder not take this drug.
-If severe constipation lasts for more than 4 days, this drug should be discontinued.

Use: For the treatment of irritable bowel syndrome with diarrhea.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Viberzi?

Avoid drinking alcohol. It may increase your risk of pancreas problems.

See also: Viberzi and alcohol (in more detail)

Avoid taking anti-diarrhea medicine such as loperamide (Imodium) without your doctor's advice. Taking loperamide long-term while you are taking Viberzi may cause severe constipation.

Viberzi side effects

Get emergency medical help if you have signs of an allergic reaction to Viberzi: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop taking Viberzi and call your doctor at once if you have:

  • new or worsening stomach pain (may be severe);

  • nausea and vomiting;

  • constipation lasting longer than 4 days; or

  • severe pain in your upper stomach spreading to your back.

Side effects may be more likely in older adults.

Common Viberzi side effects may include:

  • constipation;

  • nausea; or

  • stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Viberzi?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • alosetron or other medications to treat irritable bowel syndrome.

  • atropine;

  • cold or allergy medicine that contains an antihistamine (Benadryl and others);

  • medicine to treat Parkinson's disease;

  • medicine to treat excess stomach acid, stomach ulcer, or motion sickness;

  • narcotic medication;

  • bladder or urinary medicines - darifenacin, fesoterodine, oxybutynin, tolterodine, solifenacin; or

  • a bronchodilator - aclidinium, ipratropium, tiotropium, umeclidinium.

This list is not complete. Other drugs may interact with eluxadoline, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Viberzi only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.