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Eluxadoline

Generic Name: eluxadoline (EL ux AD oh leen)
Brand Name: Viberzi

Medically reviewed on April 30, 2018

What is eluxadoline?

Eluxadoline works directly in your intestines to slow the movement of food during digestion. Eluxadoline also makes the nerves in your intestines less sensitive to stimulation.

Eluxadoline is used to treat irritable bowel syndrome when the main symptom is diarrhea.

Eluxadoline may also be used for purposes not listed in this medication guide.

Important Information

You should not use eluxadoline if you have a pancreas disorder, severe liver disease, alcoholism, a blockage in your intestines, a gallbladder disorder, or if your gallbladder has been removed.

Eluxadoline may cause constipation, which could be severe or lead to hospitalization. Call your doctor at once if you have severe or ongoing constipation.

Before taking this medicine

You should not use eluxadoline if you are allergic to it, or if you have:

  • severe constipation or a blockage in your intestines;

  • a history of gallbladder obstruction, or if your gallbladder has been removed;

  • digestive problems caused by a muscle valve called the sphincter of Oddi (SFINK-ter of OD-dee);

  • severe liver disease;

  • a pancreas disorder; or

  • a habit of drinking more than 3 alcoholic beverages per day.

Tell your doctor if you have ever had liver disease.

It is not known whether eluxadoline will harm an unborn baby. Tell your doctor if you are pregnant.

It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.

Eluxadoline is not approved for use by anyone younger than 18 years old.

How should I take eluxadoline?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Eluxadoline may be habit-forming. Misuse can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.

Take with food.

Eluxadoline may cause constipation, which could be severe or lead to hospitalization. Call your doctor at once if you have severe or ongoing constipation.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking eluxadoline?

Avoid drinking alcohol. It may increase your risk of pancreas problems.

Avoid taking anti-diarrhea medicine such as loperamide (Imodium) without your doctor's advice. Taking loperamide long-term while you are taking eluxadoline may cause severe constipation.

Eluxadoline side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop taking eluxadoline and call your doctor at once if you have:

  • new or worsening stomach pain (may be severe);

  • nausea and vomiting;

  • severe constipation;

  • constipation lasting longer than 4 days; or

  • severe pain in your upper stomach spreading to your back.

Side effects may be more likely in older adults.

Common side effects may include:

  • constipation;

  • nausea; or

  • stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Eluxadoline dosing information

Usual Adult Dose for Irritable Bowel Syndrome:

Usual dose: 100 mg orally twice a day

Comments:
-Dose should be reduced to 75 mg orally twice a day for patients unable to tolerate usual dose.
-If severe constipation develops, this drug should be discontinued.

Use: For the treatment of irritable bowel syndrome with diarrhea.

What other drugs will affect eluxadoline?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect eluxadoline, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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