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Eluxadoline Dosage

Applies to the following strength(s): 75 mg ; 100 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Irritable Bowel Syndrome

Usual dose: 100 mg orally twice a day

Dose for Patients without a Gallbladder: 75 mg orally twice a day

Comments:
-Dose may be reduced to 75 mg orally twice a day for patients unable to tolerate usual dose.
-If severe constipation lasts for more than 4 days, this drug should be discontinued.

Use: For the treatment of irritable bowel syndrome with diarrhea.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Severe Hepatic Impairment (Child-Pugh C): Contraindicated
Mild to Moderate Hepatic Impairment (Child-Pugh A or B): 75 mg orally twice a day

Dose Adjustments

Recommended dose 75 mg orally twice a day:
-For patients who do not have a gallbladder
-For patients unable to tolerate the 100 mg dose
-For patients who are receiving concomitant OATP1B1 inhibitors
-For patients with mild or moderate hepatic impairment

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV

Dialysis

Data not available

Other Comments

Administration advice:
-Take orally twice a day with food
-If a dose is missed, take the next dose at the regular time; do not take 2 doses at the same time.

General:
-This drug should be discontinued in patients who develop severe constipation for more than 4 days.
-Loperamide may be used for the acute management of severe diarrhea, but it should be discontinued if constipation develops; patients should not take alosetron or loperamide on a chronic basis due to the potential for constipation.
-Patients should avoid concomitant use of medications that may cause constipation.

Monitoring:
-Monitor for constipation.
-Monitor for signs and symptoms of sphincter of Oddi spasm (e.g., acute worsening of abdominal pain [acute epigastric or right upper quadrant biliary pain] that may radiate to the back or shoulder and associated with pancreatic enzyme or hepatic transaminase elevations, especially within first few weeks.

Patient advice:
-If unusual or severe abdominal pain develops, patients should be instructed to stop therapy and seek medical attention.
-Patients should contact their health care professional if they experience constipation lasting more than 4 days.
-Patients should avoid concomitant use of medications that may cause constipation.
-Patients should avoid chronic and acute excessive alcohol intake.

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