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Eluxadoline Dosage

Applies to the following strength(s): 75 mg ; 100 mg

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Irritable Bowel Syndrome

Usual dose: 100 mg orally twice a day

Dose for Patients without a Gallbladder: 75 mg orally twice a day

-Dose may be reduced to 75 mg orally twice a day for patients unable to tolerate usual dose.
-If severe constipation lasts for more than 4 days, this drug should be discontinued.

Use: For the treatment of irritable bowel syndrome with diarrhea.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Severe Hepatic Impairment (Child-Pugh C): Contraindicated
Mild to Moderate Hepatic Impairment (Child-Pugh A or B): 75 mg orally twice a day

Dose Adjustments

Recommended dose 75 mg orally twice a day:
-For patients who do not have a gallbladder
-For patients unable to tolerate the 100 mg dose
-For patients who are receiving concomitant OATP1B1 inhibitors
-For patients with mild or moderate hepatic impairment


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV


Data not available

Other Comments

Administration advice:
-Take orally twice a day with food
-If a dose is missed, take the next dose at the regular time; do not take 2 doses at the same time.

-This drug should be discontinued in patients who develop severe constipation for more than 4 days.
-Loperamide may be used for the acute management of severe diarrhea, but it should be discontinued if constipation develops; patients should not take alosetron or loperamide on a chronic basis due to the potential for constipation.
-Patients should avoid concomitant use of medications that may cause constipation.

-Monitor for constipation.
-Monitor for signs and symptoms of sphincter of Oddi spasm (e.g., acute worsening of abdominal pain [acute epigastric or right upper quadrant biliary pain] that may radiate to the back or shoulder and associated with pancreatic enzyme or hepatic transaminase elevations, especially within first few weeks.

Patient advice:
-If unusual or severe abdominal pain develops, patients should be instructed to stop therapy and seek medical attention.
-Patients should contact their health care professional if they experience constipation lasting more than 4 days.
-Patients should avoid concomitant use of medications that may cause constipation.
-Patients should avoid chronic and acute excessive alcohol intake.