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Eluxadoline Dosage

Medically reviewed by Last updated on Jun 13, 2023.

Applies to the following strengths: 75 mg; 100 mg

Usual Adult Dose for Irritable Bowel Syndrome

Usual dose: 100 mg orally twice a day


Use: For the treatment of irritable bowel syndrome with diarrhea.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Mild to Moderate Hepatic Impairment (Child-Pugh A or B): 75 mg orally twice a day
Severe Hepatic Impairment (Child-Pugh C): Contraindicated

Dose Adjustments

For patients unable to tolerate the usual dose: Reduce dose to 75 mg orally twice a day

For patients receiving concomitant OATP1B1 inhibitors: Reduce dose to 75 mg orally twice a day


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV


Data not available

Other Comments

Administration advice:



Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.