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Generic name: tenapanor
Dosage form: Tablets
Drug class: NHE3 inhibitors
Approval date: September 12, 2019
Company: Ardelyx, Inc.
Treatment for: Irritable Bowel Syndrome with Constipation (IBS-C)

Medically reviewed by Judith Stewart, BPharm. Last updated on Sep 4, 2023.

Medication Guide

Read this Medication Guide before you start treatment. This information does not take the place of talking with your healthcare provider about your medical condition or your treatment.

What is Ibsrela?

Ibsrela is a prescription medicine used in adults to treat:

It is not known if this medicine is safe and effective in children less than 18 years of age.


Ibsrela can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).

See Ibsrela side effects for more information about side effects.

Who should not take Ibsrela?

Before taking Ibsrela

Before you take Ibsrela, tell your doctor about all your medical conditions, including if you:

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

How should I take Ibsrela?

Ibsrela side effects

Ibsrela can cause serious side effects, including:

The other most common side effects include:

These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to

How should I store Ibsrela?

Keep Ibsrela and all medicines out of the reach of children.

General information about the safe and effective use of Ibsrela.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms that you have. It may harm them. You can ask your healthcare provider or pharmacist for information that is written for health professionals.

What are the ingredients in Ibsrela?

Active ingredient: tenapanor hydrochloride

Inactive ingredients: colloidal silicon dioxide, hypromellose, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, propyl gallate, stearic acid, tartaric acid, titanium dioxide, and triacetin.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.