Generic Name: plecanatide (ple KAN a tide)
Brand Name: Trulance
Medically reviewed on March 29, 2017.
What is plecanatide?
Plecanatide is used to treat chronic idiopathic constipation.
Plecanatide works by activating certain substances within your intestines that help increase fluid secretion and muscle movement. Plecanatide also causes changes in the consistency of your stools.
Plecanatide may also be used for purposes not listed in this medication guide.
You should not use plecanatide if you are allergic to it, or if you have a blockage in your intestines. Do not give this medicine to a child younger than 6 years old.
Plecanatide is not approved for use by anyone younger than 18 years old.
Before taking this medicine
You should not use plecanatide if you are allergic to it, or if you have:
a blockage in your intestines.
Do not give this medicine to younger than 6 years old.
Plecanatide is not approved for use by anyone younger than 18 years old. In animal studies, plecanatide caused severe dehydration leading to death.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether plecanatide passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
How should I take plecanatide?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
You may take plecanatide with or without food. Swallow the tablet whole.
If you cannot swallow the tablet whole, you may crush and mix the tablet with a spoonful of water or applesauce. Swallow this mixture right away. Do not save it for later use.
A plecanatide tablet mixed with water may also be given through a nasogastric (NG) feeding tube using a catheter-tipped syringe. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Store at room temperature away from moisture and heat.
Keep the tablets in their original bottle or blister pack until you are ready to take one. You may remove the packing coil from inside the pill bottle. But leave the packet or canister of moisture-absorbing preservative inside the bottle.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking plecanatide?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Plecanatide side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Diarrhea is a common side effect of plecanatide.
Stop using plecanatide and call your doctor at once if you have severe diarrhea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Plecanatide dosing information
Usual Adult Dose for Chronic Idiopathic Constipation:
3 mg orally once a day
Use: Treatment of chronic idiopathic constipation (CIC)
Usual Pediatric Dose for Chronic Idiopathic Constipation:
-Under Age 6 Years: Contraindicated.
-Age 6 to Under 18 Years: Not recommended.
What other drugs will affect plecanatide?
Other drugs may interact with plecanatide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 1.02.
More about plecanatide
- Plecanatide Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 84 Reviews – Add your own review/rating
- Drug class: guanylate cyclase-C agonists
Other brands: Trulance