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Medications for Chronic Idiopathic Constipation

Other names: CIC; Constipation, Chronic Idiopathic

Chronic Idiopathic Constipation (CIC) is chronic constipation that has no identifiable cause, it does not fit the criteria of another gastrointestinal diagnosis and it is not the result of an underlying illness or side effect of medication. Symptoms of chronic constipation are ongoing and can include difficulty passing stools, hard or infrequent bowel movements, pain during bowel movement, or the inability to pass a bowel movement after straining.

Drugs used to treat Chronic Idiopathic Constipation

The following list of medications are in some way related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Trulance 5.8 197 reviews for Trulance to treat Chronic Idiopathic Constipation
Rx N

Generic name: plecanatide systemic

Drug class: guanylate cyclase-C agonists

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Motegrity 5.4 59 reviews for Motegrity to treat Chronic Idiopathic Constipation
Rx N

Generic name: prucalopride systemic

Drug class: serotoninergic neuroenteric modulators

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Linzess 6.6 616 reviews for Linzess to treat Chronic Idiopathic Constipation
Rx C N

Generic name: linaclotide systemic

Drug class: guanylate cyclase-C agonists

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

plecanatide 5.8 201 reviews for plecanatide to treat Chronic Idiopathic Constipation
Rx N

Generic name: plecanatide systemic

Brand name:  Trulance

Drug class: guanylate cyclase-C agonists

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph

prucalopride 5.3 86 reviews for prucalopride to treat Chronic Idiopathic Constipation
Rx N

Generic name: prucalopride systemic

Brand name:  Motegrity

Drug class: serotoninergic neuroenteric modulators

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph

Amitiza 5.7 161 reviews for Amitiza to treat Chronic Idiopathic Constipation
Rx C N

Generic name: lubiprostone systemic

Drug class: chloride channel activators

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

lubiprostone 5.7 162 reviews for lubiprostone to treat Chronic Idiopathic Constipation
Rx C N

Generic name: lubiprostone systemic

Brand name:  Amitiza

Drug class: chloride channel activators

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

linaclotide 6.6 616 reviews for linaclotide to treat Chronic Idiopathic Constipation
Rx C N

Generic name: linaclotide systemic

Brand name:  Linzess

Drug class: guanylate cyclase-C agonists

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph

Pizensy Rate Add review
Rx N

Generic name: lactitol systemic

Drug class: laxatives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

lactitol Rate Add review
Rx N

Generic name: lactitol systemic

Brand name:  Pizensy

Drug class: laxatives

For consumers: dosage, interactions, side effects

Frequently asked questions

Learn more about Chronic Idiopathic Constipation

Care guides

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.