Skip to Content

Medications for Chronic Idiopathic Constipation

Other names: Constipation, Chronic Idiopathic; Functional Constipation

About Chronic Idiopathic Constipation

Chronic Idiopathic Constipation (CIC) is chronic constipation that has no identifiable cause, it does not fit the criteria of another gastrointestinal diagnosis and it is not the result of an underlying illness or side effect of medication. Symptoms of chronic constipation are ongoing and can include difficulty passing stools, hard or infrequent bowel movements, pain during bowel movement, or the inability to pass a bowel movement after straining.

Drugs used to treat Chronic Idiopathic Constipation

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Trulance 6.2 151 reviews
Rx N

Generic name: plecanatide systemic

Drug class: guanylate cyclase-C agonists

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Motegrity 4.7 22 reviews
Rx N

Generic name: prucalopride systemic

Drug class: serotoninergic neuroenteric modulators

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

plecanatide 6.2 154 reviews
Rx N

Generic name: plecanatide systemic

Brand name:  Trulance

Drug class: guanylate cyclase-C agonists

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

prucalopride 4.3 34 reviews
Rx N

Generic name: prucalopride systemic

Brand name:  Motegrity

Drug class: serotoninergic neuroenteric modulators

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

lactitol Rate Add review
Rx N

Generic name: lactitol systemic

Brand name:  Pizensy

Drug class: laxatives

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts

Pizensy Rate Add review
Rx N

Generic name: lactitol systemic

Drug class: laxatives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription Only.
OTC Over the Counter.
Rx/OTC Prescription or Over the Counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Browse Treatment Options

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.