Linzess Side Effects

Generic name: linaclotide

Medically reviewed by Drugs.com. Last updated on Jul 1, 2024.

Note: This document provides detailed information about Linzess Side Effects associated with linaclotide. Some dosage forms listed on this page may not apply specifically to the brand name Linzess.

Applies to linaclotide: oral capsule.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.

Call your doctor right away if you have severe diarrhea with feeling of lightheadedness, dizziness, or fainting.

Serious side effects of Linzess

Along with its needed effects, linaclotide (the active ingredient contained in Linzess) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking linaclotide:

Other side effects of Linzess

Some side effects of linaclotide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to linaclotide: oral capsule.

General adverse events

The most commonly reported side effects included diarrhea, abdominal pain, flatulence, and headache.^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 50%), moderate diarrhea (up to 47%), mild diarrhea (up to 43%)
• Common (1% to 10%): Abdominal distension, abdominal pain, flatulence, severe diarrhea, viral gastroenteritis
• Uncommon (0.1% to 1%): Defecation urgency, dyspepsia, fecal incontinence, gastroesophageal reflux disease, hemorrhoidal hemorrhage, lower gastrointestinal hemorrhage, nausea, rectal hemorrhage, vomiting
• Frequency not reported: Lower abdominal pain, upper abdominal pain
• Postmarketing reports: Hematochezia^[Ref]

Abdominal distention occurred more frequently in patients given 72 mcg (2%) compared to patients given 145 mcg (1%) doses.

Diarrhea was a dose-related side effect. Approximately 33% of patients in a clinical trial developed diarrhea that resolved within 7 days; approximately 80% of patients in the same clinical trial developed diarrhea that lasted more than 28 days.^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness^[Ref]

Respiratory

• Common (1% to 10%): Sinusitis, upper respiratory tract infection^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Hemorrhoidal hemorrhage, lower gastrointestinal hemorrhage, orthostatic hypotension, rectal hemorrhage^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Urticaria
• Frequency not reported: Rash
• Postmarketing reports: Hives^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Decreased appetite, dehydration, hypokalemia
• Rare (less than 0.1%): Decreased blood bicarbonate^[Ref]

Hypersensitivity

• Postmarketing reports: Allergic reactions^[Ref]

See also:

Frequently asked questions

• What is the best way to take Linzess?
• Does Linzess help with weight loss?
• How often does diarrhea occur with Linzess?
• Suprep - Can I start the prep earlier?

Further information

Linzess side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer