Linzess Alternatives Compared
| Linzess (linaclotide) | Trulance (plecanatide) | Motegrity (prucalopride) |
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| Linzess (linaclotide) | Trulance (plecanatide) | Motegrity (prucalopride) |
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Prescription only
Prescribed for Chronic Idiopathic Constipation, Irritable Bowel Syndrome with Constipation, Functional Constipation, Irritable Bowel Syndrome. Linzess may also be used for purposes not listed in this... View more |
Prescription only
Prescribed for Irritable Bowel Syndrome with Constipation, Chronic Idiopathic Constipation. Trulance may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Chronic Idiopathic Constipation. Motegrity may also be used for purposes not listed in this medication guide. |
Related suggestions Chronic Idiopathic Constipation
Popular comparisons
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| More about Linzess (linaclotide) | More about Trulance (plecanatide) | More about Motegrity (prucalopride) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Linzess has an average rating of 6.7 out of 10 from a total of 885 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 26% reported a negative effect. |
Trulance has an average rating of 6.1 out of 10 from a total of 279 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 34% reported a negative effect. |
Motegrity has an average rating of 5.9 out of 10 from a total of 69 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 35% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
View all Linzess side effects |
View all Trulance side effects |
View all Motegrity side effects |
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| Generic Availability | ||||||||||||||||||||||||||
| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Linzess prices |
View all Trulance prices |
View all Motegrity prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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N/A |
N/A |
24 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 59 drugs are known to interact with Linzess:
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A total of 1 drugs are known to interact with Trulance:
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A total of 110 drugs are known to interact with Motegrity:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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August 30, 2012 |
January 19, 2017 |
December 14, 2018 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.