Linzess Alternatives Compared
| Linzess | Trulance | Motegrity |
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| Linzess (linaclotide) | Trulance (plecanatide) | Motegrity (prucalopride) |
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Prescription only
Prescribed for Irritable Bowel Syndrome with Constipation, Chronic Idiopathic Constipation. Linzess may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Chronic Idiopathic Constipation, Irritable Bowel Syndrome with Constipation. Trulance may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Chronic Idiopathic Constipation. Motegrity may also be used for purposes not listed in this medication guide. |
Related suggestions Chronic Idiopathic Constipation
Popular comparisons
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| More about Linzess (linaclotide) | More about Trulance (plecanatide) | More about Motegrity (prucalopride) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
No lower-cost generic available |
No lower-cost generic available |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Linzess has an average rating of 6.6 out of 10 from a total of 837 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 27% reported a negative effect. |
Trulance has an average rating of 6.0 out of 10 from a total of 264 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 34% reported a negative effect. |
Motegrity has an average rating of 5.3 out of 10 from a total of 55 ratings on Drugs.com. 41% of reviewers reported a positive effect, while 43% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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Common side effects include:
See also: Linzess side effects in more detail. |
See also: Trulance side effects in more detail. |
See also: Motegrity side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Linzess prices |
View all Trulance prices |
View all Motegrity prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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N/A |
N/A |
24 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 59 drugs are known to interact with Linzess:
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A total of 1 drugs are known to interact with Trulance:
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A total of 104 drugs are known to interact with Motegrity:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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August 30, 2012 |
January 19, 2017 |
December 14, 2018 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
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N/A |
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| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.