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Linzess (linaclotide) Disease Interactions

There are 2 disease interactions with Linzess (linaclotide):

Major

Linaclotide (Includes Linzess) ↔ gastrointestinal obstruction

Severe Potential Hazard, High plausibility. Applies to: Gastrointestinal Obstruction

The use of linaclotide is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction. Because linaclotide accelerates gastrointestinal transit, it can exacerbate a blockage.

Moderate

Linaclotide (Includes Linzess) ↔ diarrhea

Moderate Potential Hazard, Moderate plausibility. Applies to: Diarrhea, Electrolyte Abnormalities, Hypokalemia, Hyponatremia

The use of linaclotide may cause diarrhea that might be associated with dizziness, syncope, hypotension and electrolyte abnormalities (hypokalemia and hyponatremia). It is recommended to withhold dosing and rehydrate patients if severe diarrhea occurs. Care should be exercised when prescribing this agent to patients at risk of diarrhea or dehydration.

Linzess (linaclotide) drug interactions

There are 136 drug interactions with Linzess (linaclotide)

Linzess (linaclotide) alcohol/food interactions

There is 1 alcohol/food interaction with Linzess (linaclotide)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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