Linzess (linaclotide) Disease Interactions
There are 2 disease interactions with Linzess (linaclotide):
Linaclotide (applies to Linzess) gastrointestinal obstruction
Major Potential Hazard, High plausibility.
The use of linaclotide is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction. Because linaclotide accelerates gastrointestinal transit, it can exacerbate a blockage.
Linaclotide (applies to Linzess) diarrhea
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Electrolyte Abnormalities, Hypokalemia, Hyponatremia
The use of linaclotide may cause diarrhea that might be associated with dizziness, syncope, hypotension and electrolyte abnormalities (hypokalemia and hyponatremia). It is recommended to withhold dosing and rehydrate patients if severe diarrhea occurs. Care should be exercised when prescribing this agent to patients at risk of diarrhea or dehydration.
Linzess (linaclotide) drug interactions
There are 58 drug interactions with Linzess (linaclotide)
Linzess (linaclotide) alcohol/food interactions
There is 1 alcohol/food interaction with Linzess (linaclotide)
More about Linzess (linaclotide)
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- Drug class: guanylate cyclase-C agonists
- FDA Approval History
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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