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Medications for Irritable Bowel Syndrome with Constipation

Other names: Constipation-Predominant IBS; Constipation-Predominant Irritable Bowel Syndrome; IBS-C

Irritable bowel syndrome with constipation (IBS-C), the constipation-predominant subtype of IBS, affects around 34% of people with IBS. It is defined as constipation associated with abdominal pain that is generally relieved by passing a bowel motion (defecation). People with IBS-C are more likely to be older age and of lower socioeconomic status. More than 25% of their bowel movements are hard or lumpy, and loose or watery stools make up less than 25% of their bowel movements.

Research suggests people with IBS-C have a lower quality of life and more impairment in their day-to-day activities than people with other subtypes of IBS. 

Drugs used to treat Irritable Bowel Syndrome with Constipation

The medications listed below are related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Linzess 6.5 243 reviews for Linzess to treat Irritable Bowel Syndrome with Constipation
Rx C N
Generic name:
linaclotide systemic
Drug class:
guanylate cyclase-C agonists
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Zelnorm 8.4 31 reviews for Zelnorm to treat Irritable Bowel Syndrome with Constipation
Rx B N
Generic name:
tegaserod systemic
Drug class:
serotoninergic neuroenteric modulators
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Amitiza 5.6 72 reviews for Amitiza to treat Irritable Bowel Syndrome with Constipation
Rx C N
Generic name:
lubiprostone systemic
Drug class:
chloride channel activators
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Ibsrela 9.0 4 reviews for Ibsrela to treat Irritable Bowel Syndrome with Constipation
Rx N
Generic name:
tenapanor systemic
Drug class:
NHE3 inhibitors
For consumers:
dosage, side effects
For professionals:
Prescribing Information
Trulance 6.5 72 reviews for Trulance to treat Irritable Bowel Syndrome with Constipation
Rx N
Generic name:
plecanatide systemic
Drug class:
guanylate cyclase-C agonists
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
lubiprostone 5.7 73 reviews for lubiprostone to treat Irritable Bowel Syndrome with Constipation
Rx C N
Generic name:
lubiprostone systemic
Brand name:
Amitiza
Drug class:
chloride channel activators
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
linaclotide 6.5 244 reviews for linaclotide to treat Irritable Bowel Syndrome with Constipation
Rx C N
Generic name:
linaclotide systemic
Brand name:
Linzess
Drug class:
guanylate cyclase-C agonists
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
tenapanor 8.8 7 reviews for tenapanor to treat Irritable Bowel Syndrome with Constipation
Rx N
Generic name:
tenapanor systemic
Brand name:
Ibsrela
Drug class:
NHE3 inhibitors
For consumers:
dosage, side effects
For professionals:
AHFS DI Monograph
plecanatide 6.5 72 reviews for plecanatide to treat Irritable Bowel Syndrome with Constipation
Rx N
Generic name:
plecanatide systemic
Brand name:
Trulance
Drug class:
guanylate cyclase-C agonists
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
MiraLAX Rate Add review
Rx/OTC C N
Generic name:
polyethylene glycol 3350 systemic
Drug class:
laxatives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
ClearLax Rate Add review
Rx/OTC C N
Generic name:
polyethylene glycol 3350 systemic
Drug class:
laxatives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
GaviLAX Rate Add review
Rx/OTC C N
Generic name:
polyethylene glycol 3350 systemic
Drug class:
laxatives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Gialax Rate Add review
Rx/OTC C N
Generic name:
polyethylene glycol 3350 systemic
Drug class:
laxatives
For consumers:
dosage, interactions, side effects
GlycoLax Rate Add review
Rx/OTC C N
Generic name:
polyethylene glycol 3350 systemic
Drug class:
laxatives
For consumers:
dosage, interactions, side effects
HealthyLax Rate Add review
Rx/OTC C N
Generic name:
polyethylene glycol 3350 systemic
Drug class:
laxatives
For consumers:
dosage, interactions, side effects
PEG3350 Rate Add review
Rx/OTC C N
Generic name:
polyethylene glycol 3350 systemic
Drug class:
laxatives
For consumers:
dosage, interactions, side effects
polyethylene glycol 3350 Rate Add review
Rx/OTC C N
Generic name:
polyethylene glycol 3350 systemic
Brand names:
MiraLAX, ClearLax, GaviLAX, Gialax, GlycoLax, HealthyLax, PEG3350, Purelax, SunMark ClearLax
Drug class:
laxatives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Purelax Rate Add review
Rx/OTC C N
Generic name:
polyethylene glycol 3350 systemic
Drug class:
laxatives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
SunMark ClearLax Rate Add review
Rx/OTC C N
Generic name:
polyethylene glycol 3350 systemic
Drug class:
laxatives
For consumers:
dosage, interactions, side effects

Learn more about Irritable Bowel Syndrome with Constipation

Care guides

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.