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NHE3 inhibitors

Medically reviewed by Carmen Pope, BPharm. Last updated on April 17, 2023.

What are NHE3 Inhibitors?

NHE3 Inhibitors are a class of medicine that works by inhibiting the Sodium-Proton-Exchanger subtype 3 (NHE3) in the gut. They may be used to treat constipation associated with irritable bowel syndrome with constipation.

NHE3 mediates the exchange of sodium, and sodium is an essential electrolyte in our body that helps maintain water balance, influences blood pressure, and is important for proper muscle and nerve function. High intestinal sodium absorption is one cause of high blood pressure (hypertension).

Medicines that inhibit NHE3 have been shown to reduce high blood pressure and increase the excretion of sodium in the feces, which can soften hard feces, relieving constipation. An improvement is also seen in the functioning of the left ventricle in the heart, but this does not seem to have an effect on the increase and growth of muscle cells (hypertrophy) that ultimately lead to heart enlargement.

What are NHE3 Inhibitors used for?

NHE3 inhibitors may be used for the treatment of irritable bowel syndrome with constipation (IBS-C) in adults.

What are the Side Effects of NHE3 inhibitors?

Side effects of NHE3 inhibitors include dehydration (which can be serious in the old or the young), diarrhea, bloating, flatulence, abnormal bowel sounds, low blood pressure, and dizziness.

Are there any Interactions with NHE3 Inhibitors?

There are no known interactions with NHE3 inhibitors.

List of NHE3 inhibitors

View by  Brand | Generic
Drug Name Avg. Rating Reviews
Ibsrela (Pro)
Generic name: tenapanor
2 reviews
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

See also

Medical conditions associated with NHE3 inhibitors:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.