Medically reviewed by Carmen Fookes, BPharm Last updated on Nov 10, 2019.
What are NHE3 Inhibitors?
NHE3 Inhibitors are a class of medicine that works by inhibiting the Sodium-Proton-Exchanger subtype 3 (NHE3) in the gut.
NHE3 mediates the exchange of sodium, and sodium is an essential electrolyte in our body that helps maintain water balance, influences blood pressure, and is important for proper muscle and nerve function. High intestinal sodium absorption is one cause of high blood pressure (hypertension).
Medicines that inhibit NHE3 have been shown to reduce high blood pressure and increase the excretion of sodium in the feces, which can soften hard feces. An improvement is also seen in the functioning of the left ventricle in the heart, but this does not seem to have an effect on the increase and growth of muscle cells (hypertrophy) that ultimately lead to heart enlargement.
What are NHE3 Inhibitors Used For?
What are the Side Effects of NHE3 inhibitors?
Are There any Interactions with NHE3 Inhibitors?
There are no known interactions with NHE3 inhibitors.
List of NHE3 inhibitors:
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Generic name: tenapanor
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical conditions associated with NHE3 inhibitors: